2,932 research outputs found
Open Source Structural Engineering Truss Hand-in Form
No full textThis repository supports the article: Nicholas Vandewetering and Joshua M. Pearce, Streamlining structural engineering compliance of rooftop solar photovoltaic installations using an open-source approach, Solar Energy,
284, 2024, 113074, https://doi.org/10.1016/j.solener.2024.113074
BREAD
No full textThis project is fully documented in the paper: Shane Oberloier, Nicholas G. Whisman, Finn Hafting, Joshua M. Pearce, Open Source Framework for a Broadly Expandable and Reconfigurable Data Acquisition and Automation Device (BREAD), ''HardwareX'', 2023, e00467, https://doi.org/10.1016/j.ohx.2023.e00467
Heritability and Linkage Analysis of Appendicitis Utilizing Age at Onset
Get PDFAppendicitis usually afflicts the young, but there is a large tail in the distribution of onset age. The genetics of this disease are still not well understood. A heritability analysis and genome wide linkage analysis of a large twin dataset was undertaken. Treating age of onset of appendicitis as a censored survival trait revealed a heritability of 0.21, and found evidence of linkage to Chromosome 1p37.3. Author(s): Christopher Oldmeadow 1 * | Kerrie Mengersen 2 | Nicholas Martin 3 | David L. Duffy
Up, up, down, down: the structural biology of the SARS-CoV-2 spike protein and how it cheats the immune system
No full textSpike proteins protrude from the SARS-CoV-2 viral envelope and are responsible for initiating fusion into human epithelial cells by binding Angiotensin-Converting Enzyme 2 receptors on the host cell surface. Due to their exposed location on the outside of the virion and their key role in infection, SARS-CoV-2 spike proteins are an important target for vaccine development and drug design. Over the last two years, many spike protein structures have been experimentally determined, providing essential details into the complex structural rearrangements that occur after receptor binding and during fusion of the virion with the host cell, as well as into the interactions of spike protein molecules with antibodies. SARS-CoV-2 variants, particularly those associated with reduced vaccine efficacy, are strongly associated with mutations in two domains of the SARS-CoV-2 spike protein, namely the receptor binding domain and the N-terminal domain, which have both been structurally characterized. This review provides a comprehensive overview of the structural knowledge acquired over the past four years on the SARS-CoV-2 spike protein and its critical role in viral infection.</p
Human Perambulation as a Self Calibrating Biometric
No full textThis paper introduces a novel method of single camera gait reconstruction which is independent of the walking direction and of the camera parameters. Recognizing people by gait has unique advantages with respect to other biometric techniques: the identification of the walking subject is completely unobtrusive and the identification can be achieved at distance. Recently much research has been conducted into the recognition of frontoparallel gait. The proposed method relies on the very nature of walking to achieve the independence from walking direction. Three major assumptions have been done: human gait is cyclic; the distances between the bone joints are invariant during the execution of the movement; and the articulated leg motion is approximately planar, since almost all of the perceived motion is contained within a single limb swing plane. The method has been tested on several subjects walking freely along six different directions in a small enclosed area. The results show that recognition can be achieved without calibration and without dependence on view direction. The obtained results are particularly encouraging for future system development and for its application in real surveillance scenarios
Data for "Compositional dependence of direct transition energies in SiGeSn alloys lattice-matched to Ge/GaAs"
No full text<p>Spectroscopic ellipsometry data (raw data and optical constants extracted from data fitting, and R and Python scripts for analysis and plotting) for Si<sub>x</sub>Ge<sub>1-x-y</sub>Sn<sub>y</sub> alloys at six different compositions. Accompanies the paper "Compositional dependence of direct transition energies in SiGeSn alloys lattice-matched to Ge/GaAs" (authors: Phoebe M. Pearce, Sheau Wei Ong, Andrew D. Johnson, Eng Soon Tok, Nicholas J. Ekins-Daukes).</p>
Forbidden Colors in the Regulation of Clerical Dress from the Fourth Lateran Council (1215) to the Time of Nicholas of Cusa (d. 1464)
No full textMedieval canon law attempted to distinguish clergy from the laity by restricting their dress choices. The article focuses on prohibition of wearing red or green on the street. Both colors were identified with the nobility.The published version was published as Chapter 7 in Medieval Clothing and Textiles 1Izbicki, Thomas M. (2005), "Forbidden Colors in the Regulation of Clerical Dress from the Fourth Lateran Council (1215) to the Time of Nicholas of Cusa (d. 1464)" in Netherton, Robin and Owen-Crocker, Gale R., eds., Medieval Clothing and Textiles 1 (Boydell Press),105-114ISBN: 9781843831235 (published book
Original Intentions: Essays on Production, Reproduction, and Interpretation in the Arts of China
Full text linkBook Review of Original Intentions: Essays on Production, Reproduction, and Interpretation in the Arts of China, ed. by Nicholas Pearce and Jason Steuber. ISBN 9780813039725. Reviewed by Lindsay M. King
The maternal immune system during pregnancy and its influence on fetal development
No full textThe maternal immune system plays a critical role in the establishment, maintenance, and completion of a healthy pregnancy. However, the specific mechanisms utilized to achieve these goals are not well understood. Various cells and molecules of the immune system are key players in the development and function of the placenta and the fetus. Effector cells of the immune system act to promote and yet limit placental development. The T helper 1 (Th1)/T helper 2 (Th2) immune shift during pregnancy is well established. A fine balance between proinflammatory and anti-inflammatory influences is required. We herein review the evidence regarding maternal tolerance of fetal tissues and the underlying cell-mediated immune and humoral (hormones and cytokines) mechanisms. We also note the many unanswered questions in our understanding of these mechanisms. In addition, we summarize the clinical manifestations of an altered maternal immune system during pregnancy related to susceptibility to common viral, bacterial, and parasitic infections, as well as to autoimmune diseases.Peer reviewe
External interventions and the duration of civil wars
Full text linkThe authors combine an empirical model of external intervention, with a theoretical model of civil war duration. Their empirical model of intervention allows them to analyze civil war duration, using"expected"rather than"actual"external intervention as an explanatory variable in the duration model. Unlike previous studies, they find that external intervention is positively associated with the duration of civil war. They distinguish partial third-party interventions that extend the length of war, from multilateral"peace"operations, which have a mandate to restore peace without taking sides - and which typically take place at war's end, or at least when both sides have agreed to a cease-fire. In a future paper, the authors will examine whether partial third-party interventions - whatever their effect on a war's duration - increase the risk of war's recurrence. If that proves true, then even if interventions reduce the length of civil war, they may do so at the cost of further destabilizing the political system, and sowing the seeds of future rebellion.Children and Youth,Peace&Peacekeeping,Post Conflict Reconstruction,Post Conflict Reconstruction,International Affairs,Post Conflict Reconstruction,Social Conflict and Violence,Peace&Peacekeeping,Post Conflict Reconstruction,International Affairs
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