163,530 research outputs found
Peake, Inft. (Death, 1879-02-15)
No full textAddress: 29 Avery St.Age at death: 7 hrPg 16/1879/213/W S/City/Dr. E Peake/J Sullivan/St. Joseph's NewOriginal record filed in drawer labeled 'PATTERSON,F-PECK'
Natriuretic peptide receptors regulate cytoprotective effects in an ex vivo human 3D/bioreactor model
Get PDFIntroductionThe present study examined the effect of C-type natriuretic peptide (CNP) and biomechanical signals on anabolic and catabolic activities in chondrocyte/agarose constructs.MethodsNatriuretic peptide (Npr) 2 and 3 expression were compared in non-diseased (grade 0/1) and diseased (grade IV) human cartilage by immunofluoresence microscopy and western blotting. In separate experiments, constructs were cultured under free-swelling conditions or subjected to dynamic compression with CNP, interleukin-1β (IL-1β), the Npr2 antagonist P19 or the Npr3 agonist cANF4-23. Nitric oxide (NO) production, prostaglandin E2 (PGE2) release, glycosaminoglycan (GAG) synthesis and CNP concentration were quantified using biochemical assays. Gene expression of Npr2, Npr3, CNP, aggrecan and collagen type II were assessed by real-time qPCR. Two-way ANOVA and a post hoc Bonferroni-corrected t-test were used to analyse the data.ResultsThe present study demonstrates increased expression of natriuretic peptide receptors in diseased or older cartilage (age 70) when compared to non-diseased tissue (age 60) which showed minimal expression. There was strong parallelism in the actions of CNP on cGMP induction resulting in enhanced GAG synthesis and reduction of NO and PGE2 release induced by IL-1β. Inhibition of Npr2 with P19 maintained catabolic activities whilst specific agonism of Npr3 with cANF4-23 had the opposite effect and reduced NO and PGE2 release. Co-stimulation with CNP and dynamic compression enhanced anabolic activities and inhibited catabolic effects induced by IL-1β. The presence of CNP and the Npr2 antagonist abolished the anabolic response to mechanical loading and prevented loading-induced inhibition of NO and PGE2 release. In contrast, the presence of the Npr3 agonist had the opposite effect and increased GAG synthesis and cGMP levels in response to mechanical loading and reduced NO and PGE2 release comparable to control samples. In addition, CNP concentration and natriuretic peptide receptor expression were increased with dynamic compression.ConclusionsMechanical loading mediates endogenous CNP release leading to increased natriuretic peptide signalling. The loading-induced CNP/Npr2/cGMP signalling route mediates anabolic events and prevents catabolic activities induced by IL-1β. The CNP pathway therefore represents a potentially chondroprotective intervention for patients with OA, particularly when combined with physiotherapeutic approaches to stimulate biomechanical signals.<br/
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Linking the Gawler Craton and Mount Isa Province through hydrothermal systems in the Peake and Denison Domain, northeastern Gawler Craton
Get PDFData source: Supplementary data, https://doi.org/10.1016/j.gsf.2023.101596Tectonic reconstructions of Proterozoic Australia commonly place the Peake and Denison Domain of the northeastern Gawler Craton at the interface between the North and South Australian cratons prior to the reconfiguration of Australia’s main tectonic components in the Mesoproterozoic. However, this reconstruction is largely based on palaeomagnetic data as the geological correlations between these regions are currently limited, particularly during the Mesoproterozoic. The early Mesoproterozoic period is significant as it corresponds to major IOCG mineralization in the eastern Gawler Craton between 1600 Ma and 1575 Ma, and IOCG mineralization in the Mount Isa Province largely between 1550 Ma and 1490 Ma. Therefore, determining the relationship of the Peake and Denison Domain to the Gawler Craton and Mount Isa Province during this period is essential to evaluating mineral prospectivity in the northeastern Gawler Craton. New U–Pb LA-ICP-MS geochronology on zircon and titanite improves our understanding of the tectonothermal and hydrothermal history the Peake and Denison Domain during the latePalaeoproterozoic, early-Mesoproterozoic and the Cambrian–Ordovician periods. Titanite formed within largely calc-silicate alteration assemblages indicates the Peake and Denison Domain has a protracted history of hydrothermal activity, recording events at c. 1565 Ma, 1530–1515 Ma, c. 1500 Ma, c. 1465 Ma and c. 490 Ma. The highly calcic nature of the c. 1565–1500 Ma alteration in the Peake and Denison Domain shares strong similarities in age and character to the regional calcic-sodic alteration recorded in the Mount Isa Province. We suggest the two regions were influenced by similar hydrothermal systems during the early Mesoproterozoic, supporting reconstruction models that place the Peake and Denison Domain near the Mount Isa Province during the early-Mesoproterozoic. This highlights the prospectivity of the Peake and Denison Domain for Isan-style IOCG mineralization, but requires consideration of the post-1500 Ma rotation of prospective structures.Mitchell J. Bockmann, Justin L. Payne, Martin Hand, Laura J. Morrissey, Antonio P. Belperi
Reporting of clinical trials using group sequential methods
No full textMoran JL, Peake SL and Solomon P
ASCIA guidelines for prevention of food anaphylactic reactions in schools, preschools and child-care centres
No full textThe definitive version is available at www.blackwell-synergy.comThese guidelines have been developed by the anaphylaxis working party of the Australasian Society of Clinical Immunology and Allergy to provide advice for minimizing the risk of food-induced anaphylaxis in schools, preschools and child-care centres. The guidelines outline four steps for the prevention of food anaphylactic reactions in children at risk and food policy measures specific to school age and preschool age children.K Baumgart, S Brown, M Gold, A Kemp, R Loblay, R Loh, D Mitrou, R Mullins, J Peake, J Ruhno, M Said, J Sinclair, V Smith, W Smith, G Solley, V Soutter, M Tang, J Ziegle
sj-pdf-1-eso-10.1177_23969873231183206 – Supplemental material for Prediction of response to thrombolysis in acute stroke using neural network analysis of CT perfusion imaging
No full textSupplemental material, sj-pdf-1-eso-10.1177_23969873231183206 for Prediction of response to thrombolysis in acute stroke using neural network analysis of CT perfusion imaging by Yutong Chen, Daniel J Tozer, Weiran Liu, Edward J Peake and Hugh S Markus in European Stroke Journal</p
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