1,721,410 research outputs found

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Novel antibacterial strategies with emphasis on the characterization of β-Lactamases and β-Lactamase inhibitors

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    This Thesis records my involvement and contributions to the discovery, evaluation and characterization of novel antibacterial strategies. My Ph.D. project focussed on the characterization of a series of novel extended spectrum TEM/SHV β-lactamases and plasmid mediated Class C enzymes. This, coupled with research which I conducted in India on the prolific widespread carriage of resistant organisms, provided me with an excellent insight into the need for novel antibacterial agents to combat the rising tide of resistant organisms. Subsequently, on joining SmithKline Beecham in 1990 I performed research that led to the discovery and characterization of a variety of novel inhibitors of serine (β-lactamases. I also led a research initiative which successfully characterized a variety of new metallo-β-lactamases and identified novel inhibitors of this group of β-lactamases. Furthermore, these compounds demonstrated some potential for combating this emerging resistance mechanism. In 1995 my interests focussed on the exploitation of bacterial genomics for the identification and characterization of novel antibacterial targets. I initiated projects to evaluate fatty acid biosynthesis, cell wall biosynthesis, aromatic amino acid biosynthesis, cell division and protein secretion as antibacterial strategies. This work provided the first ever identification and characterization of the Gram positive cocci homologs of FabI (enoyl ACP reductase, fatty acid biosynthesis), MurA (UDP- N-acetylglucosamine enolpyruvyl transferase, peptidoglycan biosynthesis), EPSP synthase (5-enolpyruvylshikimate- 3-phosphate synthase, aromatic amino acid biosynthesis), FtsA, FtsZ (cell division) and SRP (signal recognition particle, protein secretion). It is my hope that this work will either directly or indirectly facilitate the discovery of pioneer antibacterial agents urgently required for our battle against bacterial pathogens in the next millennium.1. PAYNE, D. J., MARRIOTT, M. S. & AMYES S. G. B. (1991). Plasmid mediated ceftazidime resistance identified in a strain of Serratia marcescens isolated in Belgium. Journal of Antimicrobial Chemotherapy 27, 689 -693. • 2. PAYNE, D. J., MARRIOTT, M. S., CHRISTODOULOU, C. & AMYES S. G. B. (1990). TEM -E4: A f 3- lactamase which confers transferable resistance to ceftazidime. Journal of Pharmacy and Pharmacology 42, 61P. • 3. PAYNE, D. J., HOOD, J., MARRIOTT, M. S. & AMYES S. G. B. (1990). Separation of plasmid mediated extended spectrum ß- lactamases by Fast Protein Liquid Chromatography (FPLC system). FEMS Microbiology Letters 69, 195 -200. • 4. PAYNE, D. J., BLAKEMORE, P. H., DRABU, Y. & AMYES, S. G. B. (1989). Comparison of the TEM -E3 and TEM -5 13- lactamases. Journal of Antimicrobial Chemotherapy 24, 615 -617. • 5. PAYNE, D. J., MARRIOTT, M. S. & AMYES S. G. B. (1989). TEM -El: a novel 13- lactamase conferring resistance to ceftazidime. FEMS Microbiology Letters 59, 97 -100. • 6. PAYNE, D. J., MARRIOTT, M. S. & AMYES, S. G. B. (1989). Two novel f3- lactamases which confer resistance to ceftazidime. Abst. 610/0S31. Fourth European Congress of Clinical Microbiology, Nice, France. • 7. PAYNE, D. J., MARRIOTT, M. S. & AMYES, S. G. B. (1990). Comparison of TEM -E3 and TEM -10 13- lactamases. Abst. A -70. 90th American Society for Microbiology, Anaheim, California, USA. • 8. PAYNE, D. J., MARRIOTT, M. S. & AMYES, S. G. B. (1990). Characterization of a unique ceftazidime hydrolyzing (3- lactamase, TEM -E2. Journal of Medical Microbiology 32, 131 -134. • 9. PAYNE, D. J., MARRIOTT, M. S. & AMYES S. G. B. (1989). Mutants of the TEM -1 13- lactamase conferring resistance to ceftazidime. Journal of Antimicrobial Chemotherapy 24, 103 -110. • 10. PAYNE, D. J., MARRIOTT, M. S. & AMYES, S. G. B. (1989). Mutant enzymes of the TEM -1 f3- lactamase conferring resistance to third generation cephalosporins. Abst. PP2 /2. Western Pacific Congress on Infectious Diseases and Chemotherapy, Kuala Lumpur, Malaysia. • 11. PAYNE, D. J., HOOD, J., PATON, R. & AMYES, S. G. B. (1990). Lack of transferable third generation cephalosporin resistance in Scotland. Program and Abst. 15. Western Pacific Congress on Infectious Diseases and Chemotherapy, Pattaya, Thailand. • 12. WOODFORD, N., PAYNE, D. J., JOHNSON, A. P., WEINBREN, M. J., PERINPANAYAGAM, R. M., GEORGE, R. C., COOKSON, B. D. & AMYES, S. G. B. (1991). Transferable cephalosporin resistance not inhibited by clavulanic acid in Escherichia coli. Lancet 336, 8709, 253. • 13. PAYNE, D. J., WOODFORD, N. & AMYES S. G. B. (1992). Characterization of the plasmid mediated 13- lactamase BIL -1. Journal of Antimicrobial Chemotherapy 30, 119 -127. • 14. FOSBERRY, A. & PAYNE, D. J. (1992). BIL -l: an example of a plasmid mediated Class C 13- lactamase. The Fifth 13- lactamase Workshop, Holy Island. • 15. FOSBERRY, A., PAYNE, D. J., LAWLOR, E. & HODGSON, J. (1994). Cloning and sequence analysis of blaBIL -1: a plasmid mediated Class C f3- lactamase gene in Escherichia coli BS. Antimicrobial Agents and Chemotherapy 38, 1182 -1185. • 16. PAYNE, D. J. & KNOWLES, D. (1993). Plasmid mediated Class I [3- lactamases. Abst. 482. European Congress of Clinical Microbiology, Seville, Spain. • 17. AMYES, S. G. B., TAIT, S., THOMSON, C. J., PAYNE, D. J., NANDIVADA, L. S., JESUDASON, M. V., MUKUNDAN, U. D. & YOUNG H -K. (1992). Incidence of antibacterial drug resistance in aerobic faecal flora in South India. Journal of Antimicrobial Chemotherapy 29, 415 -427. • 18. TAIT, S., NANDIVADA, L. S., PAYNE, D. J., THOMSON, C. J. & AMYES, S. G. B. (1990). Resistance to antibacterial drugs in commensal bacterial flora in South India. Journal of Pharmacy and Pharmacology 42, 64P. • 19. AMYES, S. G. B., TAIT, S., THOMSON, C. J., PAYNE, D. J., MUKUNDAN, U. & JESUDASON, M.V. (1992). Reservoirs of antibiotic resistance genes. Conference on Hospital Acquired Infections, Christian Medical College Hospital, Vellore, Tamil Nadu, India. • 20. AMYES, S. G. B., NANDIVADA, L. S., PAYNE, D. J., TAIT, S., THOMSON, C. J., & JESUDASON, M. V. (1990). Incidence of antibacterial drug resistance in commensal bacteria in South India. British Society for Antimicrobial Chemotherapy, Brighton. • 21. PAYNE, D. J. & AMYES S. G. B. (1991). Comparison of the oral cephalosporin cefdinir (CI -983, FK -482), with related beta -lactams on clinical strains isolated in Scotland. In Recent Advances in Chemotherapy, Section I ( Eds: Adam, D., Lode, H. & Rubinstein, E.) p46 -47. Futuramed Publishers, Munich, Germany. • 22. PAYNE, D. J. & AMYES S. G. B (1992). The sensitivity of clinical bacteria isolated in Scotland to the oral cephalosporin, cefdinir. Drugs Under Experimental and Clinical Research XVIII (6), 225 -231. • 23. PAYNE, D. J. & AMYES S. G. B. (1993). Stability of cefdinir to extended - spectrum plasmid mediated 13- lactamases. Journal of Medical Microbiology 38, 114 -117. • 24. PAYNE, D. J. & AMYES S. G. B. (1991). Beta -lactamase stability of the oral cephalosporin cefdinir (CI -983, FK -482) compared with related antibiotics. In Recent Advances in Chemotherapy, Section I ( Eds: Adam, D., Lode, H. & Rubinstein, E.) p66 -67. Futuramed Publishers, Munich, Germany. • 25. PAYNE, D. J., COLEMAN, K. & CRAMP, R. (1991). The automated in -vitro assessment of f3- lactamase inhibitors. Journal of Antimicrobial Chemotherapy 28, 775 -776. • 26. PAYNE, D. J. & PRADHANANGA, S. L. (1996). A microtitre -based assay for the determination of IDSO's of 13- lactamase inhibitors employing reporter substrates detected at UV or visible wavelengths. Biotechnology International, 309- 312. Eds F. Fox, T. H. Connor, Universal Medical Press Inc. • 27. PAYNE, D. J. & PRADHANANGA, S. L., (1996). A microtitre -based assay for the determination of IDSO's of (3- lactamase inhibitors employing reporter substrates detected at UV or visible wavelengths. Application Note 1 -3, Molecular Devices. • 28. CRAMP, R., PAYNE, D. J. & COLEMAN, K. (1993). Overcoming enzymatic resistance to 13- lactams: rapid screening of 13- lactamase inhibitors. Abst. P17/7. Seventh International Congress on Rapid Methods and Automation in Microbiology and Immunology. • 29. PAYNE, D. J., CRAMP, R., WINSTANLEY, D. & KNOWLES, D. J. (1994). Comparative activities of clavulanic acid, sulbactam, and tazobactam against clinically important 13- lactamases. Antimicrobial Agents and Chemotherapy 38, 767 -772. • 30. PAYNE, D. J. & CRAMP, R. (1992). Determination of ID50 values for 35 plasmid mediated 13- lactamases. Abst. 10B. 7. International Congress on the Management of Infection, Amsterdam. • 31. FARMER, T. H., DEGNAN, B. A. & PAYNE, D. J. (1999). Penetration of (3- lactamase inhibitors into the periplasm of Gram negative bacteria. FEMS Microbiology Letters 176, 11 -15. • 32. FARMER, T. H., PAGE, J., PAYNE, D. J. & KNOWLES, D. (1994). Kinetic and physical studies of the 13- lactamase inhibition by a novel penem BRL 42715. Biochemical Journal 303, 825 -830. • 33. BATESON, J. H., GASSON, B. C., KHUSHI, T., NEALE, J. E., PAYNE, D. J., TOLSON, D. A. & WALKER, G. (1994). The synthesis and serine 3- lactamase inhibitory activity of some phosphonamidates of dipeptides. Biorganic & Medicinal Chemistry Letters 4, 1667 -1672. • 34. PAYNE, D. J., BATESON, J. H., TOLSON, D., GASSON, B., KHUSHI, T. & READING, C. (1995). Inhibition of P99 by phosphonamidate analogues: elucidation of the mechanism by ESMS. 6th (3- Lactamase Workshop, Holy Island, 9 -13th April). • 35. PAYNE, D. J., BATESON, J. H., TOLSON, D., GASSON, B., KHUSHI, T., LEDENT, P. & FRERE, J. M. (1996). Phosphonamidate analogues of dipeptides with carboxypeptidase A and (3- lactamase inhibitory activity: Elucidation of the mechanism of (3- lactamase inhibition by ESMS. Biochemical Journal 314, 457- 461. • 36. PAYNE, D. J., SKETT, P., APLIN, R. T., ROBINSON, C. & KNOWLES, D. (1994). 3- lactamase ragged ends detected by electrospray mass spectrometry correlates poorly with multiple banding on isoelectric focusing. Journal of Biological Mass Spectrometry 23, 159 -164. • 37. PAYNE, D. J. & AMYES, S. G. B. (1994). The effects of 13- lactams on the isoelectric focussing of 13- lactamases. Journal of Applied Bacteriology 76, 500- 505. • 38. DU, W., ORLEK, B., FAN, F., & PAYNE, D. J (1999). Inhibition of serine beta -lactamases by lipopeptides. Abst. 191. 217th American Chemical Society National Meeting, Anaheim, California, USA. • 39. PAYNE, D. J. (1993). Metallo- (3- lactamases- a new therapeutic challenge. Journal of Medical Microbiology 39, 93 -99. • 40. PAYNE, D. J., CRAMP, R., BATESON, J. H., NEALE, J. & KNOWLES, D. (1994). Rapid identification of serine and metallo -ß- lactamases Antimicrobial Agents and Chemotherapy 38, 991 -996. • 41. PAYNE, D. J., CRAMP, R., BATESON, J. H., CLARKE, G. & KNOWLES, D. (1993). Detection of metallo- and serine (3- lactamases from X.maltophilia. Abst. 1522. Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, Louisiana. • 42. PAYNE, D. J., ROWLING, P., KHUSHI, K., READING, C. & DODD, I. (1994). Biochemical characterization of X.maltophilia metallo -13- lactamases types 1 to 6 Abst. C60. Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Florida, USA. • 43. PRADHANANGA, S. L., ROWLING, P. J. E., SIMPSON, I. N. & PAYNE, D. J. (1996). Sensitivity of L -2 type 13- lactamases from Stenotrophomonas maltophilia to serine active site (3- lactamase inhibitors. Journal of Antimicrobial Chemotherapy 37, 394 -396. • 44. STUNT, R. A., THOMSON, C. J., PAYNE, D. J. & AMYES, S. G. B. (1998). A study of the mechanisms involved in imipenem resistance in Pseudomonas aeruginosa isolates from Japan. Journal Antimicrobial Chemotherapy 42, 272- 273. • 45. STUNT, R. A., THOMSON, C. J., PAYNE, D. J. & AMYES, S. G. B. (1998). The production of a novel carbapenem -hydrolyzing (3- lactamase in Aeromonas veronii biovar sobria and its association with imipenem resistance. Journal of Antimicrobial Chemotherapy 42, 835 -836. • 46. STUNT, R. A., AMYES, A. K. B., THOMSON, C. J., PAYNE, D. J. & AMYES, S. G. B. (1997). Isolation of imipenem resistant Aeromonas veronii by sobria, that possess a novel carbapenemase, from a water source in India. Abst. C -96. Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Canada. • 47. STUNT, R. A., THOMSON, C. J., PAYNE, D. J. & AMYES, S. G. B. (1996). A rapid substrate based technique for the detection and characterization of carbapenemases in clinical isolates after IEF. Abst. C35. Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, USA. • 48. MUNN, J. G. R., THOMSON, C. J., PAYNE, D. J. & AMYES, S. G. B. (1995). Prevalence of metallo -13- lactamases in clinical isolates of Flavobacterium. Panceltic Microbiology Society, Dublin, Ireland. • 49. MUNN, J. G. R., PAYNE, D. J., ROWLING, P. J. E., THOMSON, C. J & AMYES, S. G. B. (1995). Isolation and characterization of two f3- lactamases from a clinical isolate of Flavobacterium spiritivorum. 7th European Congress of Clinical Microbiology and Infectious Diseases, Vienna. • 50. MUNN, J. G. R., THOMSON, C. J., PAYNE, D. J. & AMYES, S. G. B. (1994). Characterization of imipenem hydrolysing metallo -13- lactamases from 2 Bacteroides fragilis clinical isolates. Abst. A61. 94th General Meeting of the American Society of Microbiology, Las Vegas, Nevada, USA. • 51. WALSH, T. R., PAYNE, D.J., McGOWAN, P. & BENNETT, P.M. (1995). A clinical isolate of A.sobria, strain 163a, possesses three chromosomally mediated inducible ß- lactamases, a cephalosporinase, a penicillinase and a metallo- 13- lactamase. Journal of Antimicrobial Chemotherapy 35, 271 -279. • 52. WALSH, T. R., NEVILLE, W. A., HARAN, M. H., TOLSON, D., PAYNE, D. J. , BATESON, J. H., MACGOWAN, A. P. & BENNETT, P. M. (1998). Nucleotide and amino acid sequences of the metallo -13- lactamase ImiS from Aeromonas veronii by. sobria. Antimicrobial Agents Chemotherapy 42, 436- 439. • 53. KHUSHI, T., PAYNE, D.J., FOSBERRY, A. & READING, C. (1996). Production of metal dependent 13- lactamases by clinical strains of B.fragilis isolated before 1987. Journal of Antimicrobial Chemotherapy 37, 345 -350. • 54. PAYNE, D. J., BETRIU, C., KHUSHI, T., HOYLE, C., READING, C. & KNOWLES, D. (1995). Imipenem hydrolyzing (3- lactamases from 6 strains of B.fragilis. Abst. A75. 95th General Meeting of the American Society of Microbiology, Washington, D. C, USA. • 55. GILPIN, M., FULSTON, M., PAYNE, D. J., CRAMP, R. & HOOD, I. (1995). Isolation and structure determination of two novel phenazines from a Streptomycete with inhibitory activity against metalloenzymes including metallo-(3-lactamase. Journal of Antibiotics 48, 1081 -1085. • 56. PAYNE, D. J., BATESON, J. H., PROCTOR, D., KHUSHI, T., FARMER, T. H., TOLSON, A. D., BELL, D., SKETT, P. W., MARSHALL A. C., REID, R., GHOSEZ, L. Y., COMBRET, Y. & MARCHAND-BRYNAERT, J. (1996). Inhibition of metallo-13- lactamases by a series of mercaptoacetic acid thiolester derivatives. Antimicrobial Agents and Chemotherapy 41, 135 -140. • 57. PAYNE, D. J., BATESON, J. H., GASSON, B. C., KHUSHI, T., PROCTOR, D., PEARSON, S. & REID, R. (1997). Inhibition of metallo- 13- lactamases by a series of thiol ester derivatives of mercaptophenylacetic acid. FEMS Microbiology Letters 157, 171 -175. • 58. PAYNE, D. J., BATESON, J. H., CHEEVER, C., FARMER, T., GILPIN, M., NICONOVICH, N., PEARSON, S., RITTENHOUSE, S. & WITTY, D. (1999). Potent, broad -spectrum, mercaptocarboxylate inhibitors of metallo-(3- lactamases (MBLs). Abst. A10. 99th American Society of Microbiology General Meeting, Chicago, IL, USA. • 59. GILPIN, M., BEST, D., WITTY, D., BATESON, J.H., PEARSON, S, CHEEVER, C., NICONOVICH, N., RITTENHOUSE, S. & PAYNE, D. J. (2000). SAR and selectivity analysis of a series of thiazolidine and proline mercaptocarboxylate MBL inhibitors. Abst. 1225. Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Canada 2000. • 60. BATESON, J. H., WITTY, D. R., GASSON, B. C., BEST, D. J. & PAYNE, D. J.(1997). Beta -thiopropionyl- aminoacid derivatives and their use as beta -lactamase inhibitors. WO09730027A1. • 61. GILPIN, M. L., PAYNE, D. J. & BATESON, J. H. (1997). Pyrrolidine and thiazole derivatives with antibacterial and metallo- beta -lactamase inhibitory properties. WO09710225. • 62. FABIANE, S.M., SOHI, M., WAN, T., PAYNE, D. J., BATESON, J. H. & SUTTON, B. J. (1996). Crystal structure of a metallo f3- lactamase II from B.cereus at 2.5 A. Abst. PSO4.02.22. International Congresss of Crystallography XVII, Seatle, Washington. • 63. FABIANE, S. M., SOHI, M. K., WAN, T., PAYNE, D. J., BATESON, J. H., MITCHELL, T. & SUTTON, B. J. (1998). The crystal structure of the zinc - dependent metallo -(3- lactamase II from Bacillus cereus at 1.9Á resolution. Biochemistry 37, 12404 -12411. • 64. CONCHA, N. O., JANSON C. A., GASSON, B. C., ROWLING, P., PEARSON, S., CHEEVER, C. A., CLARKE B. P., LEWIS, C., PAYNE, D. J., BATESON, J. H. & ABDEL- MEGUID, S. S (2000). The crystal structure of the IMP -1 metallo (3- lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad - spectrum inhibitor. Biochemistry 39, 4288 -4298. • 65. DU, W., BATESON, J. H., GILPIN, M. WITTY, D. & PAYNE, D. J. (1999). Unusual inhibition of serine beta -lactamases by mercaptocarboxylate inhibitors of metallo- beta -lactamase. Abst. A -4. 99th. American Society of Microbiology General Meeting, Chicago, Il, USA. • 66. PAYNE, D. J. & AMYES S. G. B. (1991). Transferable resistance to extended spectrum 13- lactams: a major threat or a minor inconvenience. Journal of Antimicrobial Chemotherapy 27, 255 -261. (LEADING ARTICLE) • 67. PAYNE, D. J. (1996) Laboratory detection and investigation of zinc 13- lactamases. Invited speaker, European Congress of Chemotherapy, Glasgow UK. Abstr. C17. • 68. PAYNE, D. J. (1992). 13- lactamase mediated resistance in nosocomial infections. Conference on Hospital Acquired Infections, Christian Medical College Hospital, Vellore, Tamil Nadu, India. • 69. AMYES, S. G. B., PAYNE, D. J. & DU BOIS, S. K. (1992). Plasmid mediated 3- lactamases responsible for penicillin and cephalosporin hydrolysis. Journal of Medical Microbiology 36, 6 -9. • 70. COLEMAN, K., PAYNE, D. J., SIMPSON, I. N. & THORBURN, C. (1993). Highlights of the 6th European Congress of Clinical Microbiology and Infectious Diseases. Current Opinions on Investigational Drugs 2, (7) 851 -852. • 71. PEARSON, S., LONSDALE, J. T. & PAYNE, D. J. (1996). Review of the Infectious diseases manual. Journal Antimicrobial Chemotherapy 39, 113 -114. • 72. PAYNE, D. J. & FARMER, T. (1998) Biochemical and enzyme kinetic applications for the characterization of (3- lactamases. From: Methods in Molecular Medicine, Vol 15: Molecular Bacteriology: Protocols and Clinical Applications Edited by Woodford, N and Johnson, A. Humana Press Inc. • 73. PAYNE, D. J. & THOMSON, C. J. (1998) Molecular approaches for the detection and identification of (3- lactamases. From: Methods in Molecular Medicine, Vol 15: Molecular Bacteriology: Protocols and Clinical Applications Edited by Woodford, N and Johnson, A. Humana Press Inc. • 74. COLEMAN, K., ATHALYE, M., CLANCEY, A., DAVISON, M., PAYNE, D. J., PERRY, C. & CHOPRA, I. (1994). Bacterial resistance mechanisms as therapeutic targets. Journal of Antimicrobial Chemotherapy, 33, 1091 -1116. • 75. PAYNE, D. J., DU, W. & BATESON, J.H. (2000). 13- lactamase epidemiology and the utility of established and novel ß- lactamase inhibitors. Expert Opinions Invest. Drugs, 9(2), 247 -261. • 76. PAYNE, D. J. (1999). Metallo -(3- lactamase inhibitors: disarming an undesired factory. Conference on Controlling the Proliferation of the Microbial Cell Factory. European Commission Sectoral Meeting. Verona, Italy. • 77. PAYNE, D. J. (1999) Broad spectrum inhibitors of metallo -(3- lactamases. 3rd International Antibacterial Drug Discovery and Development Summit. Princeton. NJ. USA. • 78. PAYNE, D. J. (1999) Discovery of novel inhibitors of metallo -13- lactamases. 40th Annual Buffalo Medicinal Chemistry Symposium. Buffalo, NY, USA. • 79. UTRUP, L. J., Rl TTERNHOUSE, S. F., PAYNE, D. J., PERRY, C. R. & POUPARD, J. A. (1993). Providencia producing discrepant results with ampicillin and Augmentin have 13- lactamases with high isoelectric points. Abst. A88. 93rd American Society of Microbiology, Atlanta, Georgia, USA. • 80. PAYNE, D. J. (1997) The search for new antibacterial agents - new approaches. Invited speaker, Royal College of Physicians of Edinburgh, Symposium on Infectious Diseases and Travel Medicine, Edinburgh, UK. • 81. PAYNE, D. J. (2000). Bacterial fatty acid biosynthesis: A genomics drivern target. 4th International Antibacterial Drug Discovery and Development Summit, Princeton, NJ, USA. • 82. DEBOUCK, C., GENTRY, D. R., LONSDALE, J. T., MOONEY, J. L., PAYNE, D. J., PEARSON, S. C., SHILLING, L. K., VAN ALLER, G., WANG, M. & ZHONG, Y. Y. (1999). Staphylococcus aureus FabH. Patent Number: EP- 916730 -A2. • 83. GENTRY, D. R., LONSDALE, J. T., PAYNE, D. J., PEARSON, S. C. & VAN ALLER, G. (1998). Streptococcus pneumoniae FabD. WO9822133 -A1. • 84. GENTRY, D. R., LONSDALE, J. T., PAYNE, D. J. & PEARSON, S. C. (1998). Staphylococcus aureus Fab D polynucleotides. US5,827,689. • 85. GENTRY, D. R., LONSDALE, J. T., PAYNE, D. J. & PEARSON, S. C. (1998) Streptococcus pneumoniae FabH -

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Author Index

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    koamabayili/VECTRON-author-checklist: VECTRON author checklist

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    We have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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