414 research outputs found
Sebastien Rale vs. New England: A Case Study of Frontier Conflict
No full textAuthor\u27s original abstract: A study was made of the Jesuit missionary, Sebastien Rale, and his role in New England-New France relations. French and English primary and secondary materials were examined to give the broadest possible view of the man and to place him in historical context.
It was found that Sebastien Rale was not an agent of New France. The conflicting opinions surrounding the mission of Norridgewock and the border war of the 1720\u27s were traced to the problems of Massachusetts-Abnaki relations. Rale\u27s frequent and testy letters to the government of the Bay Colony were blunt reactions to what he viewed as religious and territorial threats against his mission.
The frontier conflict between 1713 and 1722 was not the result of French Imperial policy. The French insisted that the Abnakis were allies but refused active participation in the Indians\u27 quarrel with New England. Policy was developed in Maine by the Jesuits. The missionaries were only secondarily interested in Quebec\u27s desire to prevent Massachusetts\u27 settlement of the Kennebec. With the declaration of war in July, 1722, however, the Jesuits left the Abnakis in the hands of the governor and the intendant of New France on whom the Indians relied for vital war supplies.
Finally, the controversial attack on Norridgewock was appraised. It was found that no secondary account had fully evaluated the sources. Examination led to the discovery of crucial inconsistencies in the primary accounts of New England. The French sources were found to be based on the understandably confused impressions of the fleeing Indians. In large measure the English sources present the more valid picture: the sudden attack, the panicked confusion, and Sebastien Rale dying with gun in hand. After Rale\u27s death the war drew to a close. Without Sebastien Rale\u27s persuasion and determination, the Abnakis were not able to present a united front against colonial expansion
Steve J. Chavez recital thesis 2012
No full textThesis (M.M.)
California State University, Los Angeles, 2012Committee members: Sebastien Vallee, Jeffrey Benedict, John KennedyThe musical selections from this Master recital were not chosen with a specific theme in mind, rather each selection was carefully selected to represent the requisite musical styles stemming from the 18th to 20th century.All the literature was selected based on the requirements of the music department representing the technical skill level worthy of a graduate student from the institution of California State University, Los Angeles. This written project is the presentation of historical and musical research gathered by this author in preparation for this recital. The selections of Bach, Handel, Beethoven, Schubert, Faure, Menotti, Hoiby, and Barber are discussed in turn
Considerations sur l'ordre de Cincinnatus, [electronic resource] : ou imitation d'un pamphlet anglo-americain. Par le comte de Mirabeau. Suivies de plusieurs pieces relatives a cette institution; ... d'un pamphlet du Docteur Price, intitule: Observations on the importance of the American Revolution, ...
No full textSebastien Roch Nicholas Chamfort is given as joint author by Querard and Barbier.A reissue of the 1784 Londres edition, with a different title-page.Sig. H1 is a cancel - The 'Avis' is dated: Londres, 20 septembre, 1784.Printer's name from colophon.Electronic reproduction.English Short Title Catalog,Reproduction of original from British Library
Limit Theorem for a Modified Leland Hedging Strategy under Constant Transaction Costs rate
No full textWe study the Leland model for hedging portfolios in the presence of a constant proportional transaction costs coefficient. The modified Leland's strategy recently defined by the second author, contrarily to the classical one, ensures the asymptotic replication of a large class of payoff. In this setting, we prove a limit theorem for the deviation between the real portfolio and the payoff. As Pergamenshchikov did in the framework of the usual Leland's strategy, we identify the rate of convergence and the associated limit distribution. This rate turns out to be improved using the modified strategy and non periodic revision dates.Asymptotic hedging ; Leland-Lott strategy ; Transaction costs ; Martingale limit theorem.
Going Serverless with Knative on Kubernetes
No full textAbstract:
After reviewing some of the latest evolutions in Kubernetes we will discuss the serverless computing paradigm and highlight a few application use-cases. We will then introduce Knative, a system built on top of Kubernetes which provides components to build and serve applications as well as manage events. Through quick demos will demonstrate several key capabilities like scaling to zero and also highlight future directions with service mesh technologies.
Bio:
Sebastien is the co-founder of TriggerMesh (https://triggermesh.com) a serverless management platform built on Knative. He is the author of the Docker and Kubernetes O'Reilly cookbooks and was the CMS Tier-2 site lead at Purdue University more than 10 years ago
Tales of compassion and grief: A qualitative study of peer worker experiences in Vancouver, Canada, during the toxic drug supply crisis: Public Health Addictions Dissertation Prize Winner
No full textBackground: The public health emergency linked to illicit drug deaths was declared in 2016 in British Columbia (BC), Canada. Since that date, more than 10 000 people have lost their lives from overdoses in BC, and public health authorities increased the surveillance and interventions to prevent those deaths. In that context, a community response emerged, and people with lived experience (PWLE) of substance use stepped up to become significant actors in the overdose response strategy. From first responders in the overdose prevention sites to advisors and content specialists for public health bodies, they are at the frontline of a crisis causing thousands of deaths in the last six years. This qualitative study explores the impacts of the toxic drug supply crisis on frontline peer workers in Vancouver, Canada, by analysing their experiences, challenges, and coping mechanisms.
Methods: Data was collected via in-depth, semi-structured online interviews, between April and July 2022, with seven Vancouver frontline peers (3 females, 3 males and 1 two-spirited) working or having recently worked at any level of the overdose response since 2016. Using the inductive theme analysis method described by Braun and Clark (2013), four main themes related to the research question ‘How is the opioid crisis impacting harm reduction peer workers in Vancouver’ were identified.
Results: The overdose crisis created numerous job opportunities for PWLE of substance use in Vancouver, facilitating development of their role in the public health response to the toxic drug supply crisis in Vancouver. Peers got involved in overdose response early on and in an emergency context, emergency linked to the high increase of the number of deaths since 2016. Their work conditions, and the nature of the job, created tremendous challenges, and the risk for burnout was prevalent for most of the peers included in the study, six related mainly to grief and bereavement. Stigma linked to substance use impacted their professional and personal life, and systemic and organisational support is needed to recognise their role and improve their wellbeing. Finally, compassion was identified as the leading motivation for doing the work. PWLE working on the frontline expressed their determination to help their community and people impacted by substance use stigma. They are essential advocates for systemic and policy changes and should be included in policy making.
Conclusion: PWLE are vital actors in the public health response to the toxic drug supply crisis that impacts British Columbia. Their expertise and motivation to do the job are invaluable. They need to be supported by evidence-based interventions as they face trauma linked to grief and precarious work conditions, putting them at high risk of burnout. Participative research should be conducted in these environments to develop innovative solutions to support them and allow them to participate in improving work conditions and substance use related policies
GALDIERO is CO-FIRST AUTHOR. Phagocytes as Corrupted Policemen in Cancer-Related Inflammation
No full textInflammation is a key component of the tumor microenvironment. Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) are prototypic inflammatory cells in cancer-related inflammation. Macrophages provide a first line of resistance against infectious agents but in the ecological niche of cancer behave as corrupted policemen. TAMs promote tumor growth and metastasis by direct interactions with cancer cells, including cancer stem cells, as well as by promoting angiogenesis and tissue remodeling and suppressing effective adaptive immunity. In addition, the efficacy of chemotherapy, radiotherapy, and checkpoint blockade inhibitors is profoundly affected by regulation of TAMs. In particular, TAMs can protect and rescue tumor cells from cytotoxic therapy by orchestrating a misguided tissue repair response. Following extensive preclinical studies, there is now proof of concept that targeting tumor-promoting macrophages by diverse strategies (e.g., Trabectedin, anti-colony-stimulating factor-1 receptor antibodies) can result in antitumor activity in human cancer and further studies are ongoing. Neutrophils have long been overlooked as a minor component of the tumor microenvironment, but there is evidence for an important role of TANs in tumor progression. Targeting phagocytes (TAMs and TANs) as corrupted policemen in cancer may pave the way to innovative therapeutic strategies complementing cytoreductive therapies and immunotherapy
Corrigendum to “Reliability assessment of generic geared wind turbines by GTST-MLD model and Monte Carlo simulation” (Renewable Energy (2015) 83 (222–233), (S0960148115003158), (10.1016/j.renene.2015.04.035))
No full textThe authors regret that the Order of Authors in this article published in November 2015 is incorrect. Thus, the objective of this Corrigendum is to re-establish the originally agreed Order of Authors, as described below. Order of Authors from published Article: Yan-Fu Li, PhD; Sebastien Valla; Enrico Zio, PhD. Corrected Order of Authors to implement with this Corrigendum: Sebastien Valla, Yan-Fu Li, PhD; Enrico Zio, PhD. The Corresponding author to contact for these changes are the Primary Author, Sebastien Valla (email below). The authors would like to apologise for any inconvenience caused
The discovery of SycO reveals a new function for type three secretion effector chaperones
No full textThe Type Three Secretion (T3S) system is a device used by many Gram-negative pathogens that allows bacteria to deliver effector proteins straight into the eukaryotic cell cytosol. These effectors interfere with various signaling pathways to subvert the host cell functions. The secretion machinery of the T3S system consist of a basal body spanning the bacterial inner and outer membrane followed by a stiff hollow needle outside the bacterium. The fully assembled secretion apparatus constitute a continuous hollow conduit that connects the bacteria to the eukaryotic target cell. After cell contact, virulence proteins -called effectors- are injected directly into the cytosol of the host cell via the T3S apparatus. Several effectors of the T3S system require the assistance of specific cytosolic chaperones to be efficiently exported. There are three classes of T3S chaperones. Effector proteins are assisted by Class I chaperones. Although Class I chaperones are well characterized, their main function is still a matter of controversy. In this thesis, we demonstrate that orf155 encodes a specific chaperone for the effector YopO that we called SycO. We showed that SycO enhances YopO secretion in vitro and is required for translocation of YopO into infected cells. By pulldown assay we demonstrated that residues 20 to 77 of YopO are required and sufficient for SycO binding. Using crosslinking experiments and size exclusion chromatography analysis, we determined the stoichiometry of purified SycO and YopO-SycO complexes. SycO alone forms dimers in solution and the YopO-SycO complex has a 1:2 stoichiometry. These results suggested that SycO is a typical chaperone of the Class I. YopO is a serine/theronine kinase that interacts with Rho and Rac and disrupts the cytoskeleton of the target cells. YopO has been shown to localize at the cell plasma-membrane. By transfection of YopO-EGFP hybrid proteins into HEK293T cells, we demonstrated that the chaperone-binding domain (CBD) coincides with the membrane localization domain of YopO. Nevertheless, the CBD was not needed for the kinase activity of YopO. By ultracentrifugation, we also showed that the CBD causes YopO aggregation in the bacteria, when SycO does not cover it. Further, we show that the CBD of YopE and YopT also caused aggregation in the bacteria in the absence of SycE and SycT respectively. YopE, YopT and T3S effectors in other systems also act at the membrane of the eukaryotic host cell. We propose a new hypothesis concerning the role of T3S chaperones. The sub-cellular localization domain of effectors is aggregation-prone and creates the need for a chaperone inside bacteria. We propose that masking such aggregation-prone localization domains may be a general function for type III effector chaperones
A view of the SW. side of Tenian [picture]/
No full textPl. no. [23] of: A voyage round the world in the years MDCCXL, I, II, III, IV, by George Anson. London : Printed for the author by John and Paul Knapton ... , 1748.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an10098511; Rex Nan Kivell Collection NK742.; U6142
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