1,720,969 research outputs found
TECHNICAL FEASIBILITY AND ECONOMIC JUSTIFICATION OF E-BIKES PRODUCTION IN SLOVENIA
Full text linkPrikazana sta postopek in potek vgradnje komponent za predelavo navadnega kolesa v električno kolo. Predstavljene so vse ključne komponente električnega kolesa in njihov opis ter lastnosti in specifikacije komponent, na katere moramo biti pri izbiri pozorni. Prikazani so podatki proizvodnje, prodaje in uporabe električnih koles po svetu in v Sloveniji, kakor tudi podatki o testiranju zmogljivosti predelanega električnega kolesa.This diploma presents a procedure for installation of components for transforming an ordinary bike into an electric bike. All key components of electric bikes are shown, including their description, characteristics and specification needed. Additionally, data from testing an electric bike performance and information about production, sale and use of electric bikes around the world and in Slovenia are presented
Investigating functional aspects and inhibition of the human carnosinase CN1 enzyme by computational methods
No full textAlzheimer’s and Parkinson’s disease (AD and PD) are two of the most common neurodegenerative disorders that, together, affect more than 50 million people worldwide. The pathophysiological picture of these diseases is still unclear. This makes their pharmacological treatment more difficult. One of the molecules withpossible therapeutic potential is dipeptide carnosine (β-alanine-L-histidine), which has shown neuroprotective effects in animal models of these diseases. Unfortunately, the transferability of carnosine’s neuroprotective ability to humans is limited. This is due to the human serum carnosinase enzyme (hCN1), absent in animal serum. In humans, hCN1 was found to have an age-dependent equilibrium between its monomeric and dimeric form, with the latter being the most active and predominant form in adults. In fact, in its active form, hCN1 hydrolyzes carnosine in humans, thus preventing its beneficial pharmacological effects. Intriguingly, homocarnosine (γ-aminobutyryl-L-histidine), a close analog of the substrate carnosinase, inhibits hCN1. The reasons for such an inhibitory effect of hCN1 by homocarnosine were still unknown.The final scope of this thesis was to design novel non-hydrolysable carnosine derivatives that could prove beneficial for the treatment of AD and PD. To achieve this, I have used computational techniques to (i) characterize structural properties of carnosine vs homocarnosine, (ii) predict the structure of their Michaelis complex with hCN1 and (iii) design novel non-hydrolysable carnosine derivatives able to block hCN1 function.i. By using classical molecular dynamics, I have shown that both ligands are predominantly present in their zwitter-ionic form and mainly adopt extended conformations. The quality of the simulations was validated against experimental 1H and 13C chemical shifts.ii. By using molecular docking in conjunction with classical molecular dynamics and hybrid quantum mechanics / molecular mechanics simulations, I predicted for the first time the structure of hCN1 Michaelis complex with either carnosine or homocarnosine. Based on the obtained data, I have explained why carnosine is a hCN1’s substrate, while homocarnosine leads to hCN1 inhibition. Additionally, I propose a mechanistic explanation for the more elevated activity of hCN1 in its dimeric form.iii. Finally, based on the information obtained from the structures of Michaelis complexes, I screened a few large libraries of small molecules compounds to search novel non-hydrolysable carnosine-like derivatives. These compounds may be used to start drug discovery projects for the design of novel therapeutic agentsto treat neurodegenerative diseases. A few selected compounds are currently being tested in the group of Professor Enrico Rizzarelli, University of Catnia, Italy
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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