50 research outputs found
Polymerization of misfolded Z alpha-1 antitrypsin protein lowers CX3CR1 expression in human PBMCs
No full textThe CX3CR1 (chemokine (C-X3-C motif) receptor 1) expression levels on immune cells have significant importance in maintaining tissue homeostasis under physiological and pathological conditions. The factors implicated in the regulation of CX3CR1 and its specific ligand CX3CL1 (fractalkine) expression remain largely unknown. Recent studies provide evidence that host`s misfolded proteins occurring in the forms of polymers or amyloid fibrils can regulate CX3CR1 expression. Herein, a novel example demonstrates that polymers of human ZZ alpha-1 antitrypsin (Z-AAT) protein, resulting from its conformational misfolding due to the Z (Glu342Lys) mutation in SERPINA1 gene, strongly lower CX3CR1 mRNA expression in human PBMCs. This parallels with increase of intracellular levels of CX3CR1 and Z-AAT proteins. Presented data indicate the involvement of the CX3CR1 pathway in the Z-AAT-related disorders and further support the role of misfolded proteins in CX3CR1 regulation.Funder: Deutsche Forschungsge-meinschaft, Grant number: STR 1095/6-1, Author: Pavel Strnad. Funder: Deutsche Zentrum für Lungen-forschung, Grant number: 82DZL002A, Author: Sabina Janciauskiene. Funder: Deutsche Forschungsge-meinschaft, Grant number: SFB/TRR57, Author: Pavel Strnad. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.S
Route Finder System
No full textTitle: Route Finder System Author: Pavel Hryzlík Department: Department of Distributed and Dependable Systems Supervisor: RNDr. Michal Malohlava, Department of Distributed and Dependable Systems Abstract: The navigation systems have become an integral part of our lives. However, contemporary solutions are not able to effectively combine navigation information based on public transport and walking. Nevertheless, in large cities such functionality is beneficial. Therefore, the objective of the thesis is to design and implement a navigation system utilizing the route find library JRGPS. The resulting application Route Finder System provides an effective and user friendly way to find routes combining public transport and walking. Keywords: route, path, finder, navigation system, public transpor
Coaches'Attitudes and Opinions on the Problems of Current Sport
No full textTitle: SUMMARY Coaches' Opinions and Attitudes to the Problems of Sport today. Author: Pavel Havranek Goals of thesis: Methodology: Results: With the help of question-form survey to find out coaches' opinions and attitudes to the problems of sport today. The enquiry "Coach and sport today" was made up and repeatedly used to find out opinions and attitudes of different sport coaches. With using the question-form survey we managed to find out coaches'opinions and attitudes (n=538) to the problems of sport today as: commercialization in sport, doping, rising ofagresivity and violence in sport etc. Key words: education, job, commercialization, sport star, coac
Coaches'Attitudes and Opinions on the Problems of Current Sport
No full textTitle: SUMMARY Coaches' Opinions and Attitudes to the Problems of Sport today. Author: Pavel Havranek Goals of thesis: Methodology: Results: With the help of question-form survey to find out coaches' opinions and attitudes to the problems of sport today. The enquiry "Coach and sport today" was made up and repeatedly used to find out opinions and attitudes of different sport coaches. With using the question-form survey we managed to find out coaches'opinions and attitudes (n=538) to the problems of sport today as: commercialization in sport, doping, rising ofagresivity and violence in sport etc. Key words: education, job, commercialization, sport star, coac
Walking through Paper Dreams Pavla Z.
No full textThis diploma work is mainly a monography of a Czech author Pavel Zajicek. The base of this study is the analysis and the interpretation of his lifelong official and samizdat literary work. In the analysis of some of his prerevolutionary books as the main source I used mainly the critiques of the contemporary literary magazines. I also present the life of the author itself, especially in the context of the period he lived in. I will briefly mention two musical bands that are closely related to this personality {--} DG 307 and PPU. In my studies I use my personal e-mail with Pavel Z. and I do not forget to observe all accesible dialogues with this poet. This diploma work is mainly a monography of a Czech author Pavel Zajicek. The base of this study is the analysis and the interpretation of his lifelong official and samizdat literary work. In the analysis of some of his prerevolutionary books as the main source I used mainly the critiques of the contemporary literary magazines. I also present the life of the author itself, especially in the context of the period he lived in. I will briefly mention two musical bands that are closely related to this personality {--} DG 307 and PPU. In my studies I use my personal e-mail with Pavel Z. and I do not forget to observe all accesible dialogues with this poet. This diploma work is mainly a monography of a Czech author Pavel Zajicek. The base of this study is the analysis and the interpretation of his lifelong official and samizdat literary work. In the analysis of some of his prerevolutionary books as the main source I used mainly the critiques of the contemporary literary magazines. I also present the life of the author itself, especially in the context of the period he lived in. I will briefly mention two musical bands that are closely related to this personality {--} DG 307 and PPU. In my studies I use my personal e-mail with Pavel Z. and I do not forget to observe all accesible dialogues with this poet
Surface plasmons on nanostructures
No full textTitle: Surface plasmons on nanostructures Author: Pavel Kvasnička Department: Department of Optics and Optoelectronics Supervisor: Jiří Homola, PhD, Institute of Photonics and Electronics, Chaberská 57, 182 57 Prague 8 Supervisor's e-mail address: [email protected] Abstract: An introduction to the field of (bio)sensors based on localized surface plasmons (LSP) on metallic nanoparticles is given. Description of theoretical ap- proaches to modeling of localized surface plasmons on nanoparticles and nanostruc- tures is given. These techniques are used to study the process of optical excitation of localized surface plasmons on individual metallic nanoparticles and to detemine main performance characteristics of LSP-based sensors. Experimental study of LSP on spherical nanoparticles is reported. It is demonstrated that metallic nanoparticles supporting LSP can be used to detect changes in the refractive index or molecular binding events. Keywords: surface plasmon, nanoparticles, surface plasmon resonance sensor
Factors influencing the career start of a new teacher at a secondary school
No full textTITLE: Factors influencing the career start of a new teacher at a secondary school AUTHOR: Pavel Pešek DEPARTMENT: Charles University Faculty of Education, School Management Centre SUPERVISOR: Mgr. Irena Lhotková, Ph.D. The Author of this bachelor work focuses on a problem starting a new teacher career. He deals with their point of view on the most difficult part of teacher's work, for example "reality shock", or relation with pupils'parents. The bachelor works is divided into theoretical part and practical part. The Theoretical part details the starting a new career in general and then applies this issue on teaching profession. The Practical part is the research part, the research was done using questionnaire surveys, classrom visits and interview with the starting teachers and teachers with long experience. The Practical part concludes some recommendations for starting teachers and even indicating teachers. KEYWODS: Career start, beginning teacher, indicating teacher, placing a new teacher
Science skills of 15-years old students in the Czech Republic in the international survey PISA
No full textTitle: Scientific Literacy of 15-years old pupils in the Czech Republic in the International Survey PISA Author: Pavel Petrášek Department: Department of Physics Education Supervisor: PhDr. Martin Chvál, Ph.D., Department of Physics Education Abstract: My thesis focuses on the results of 15-year old pupils in selected tasks of the international survey PISA. It contains a brief introduction to the methodology of a survey and its realization in our conditions. The thesis presents relations between pupils` success and other variables found out in additional questionnaires, such as sex, parents` education, relation to mathematics or pupils` social and economical backgrounds. Besides the thesis contains the comparison of the importance of individual variables and results from the years 2000 and 2003. The thesis can be used as a theme for further research of mentioned relations and their comparison in a longer time horizon with other results. Electronic form of my thesis is on enclosed CD. Keywords: tests, international survey, scientific literac
French Evolutionism in the Light of Modern Science
No full textFrench Evolucionism in the Light of Modern Science Author: Pavel Šlégr This work deals especially on comparasion of thinking of two French thinkers-christian evolutionists of sekond half of 19th century and first half of 20th century: Henri Bergson and Perre Teilhard de Chardin. My comparision ges on following thematice areas: biografy of both thinkers, time and space, overcoming mechanicism, causaility and teleology, sources, direction and structure of evolution, evolutionism of 19th and 20th century. Next part of this work is devoted to undesrtanding man in work of both thinkers. This work deals also contemporary evolutionism, based especially on statistical methods of work with genes and their models. This work deals also modern physical and cosmological theories and brings them to connection with works of Bergson and Teilhard
Factors influencing the career start of a new teacher at a secondary school
No full textTITLE: Factors influencing the career start of a new teacher at a secondary school AUTHOR: Pavel Pešek DEPARTMENT: Charles University Faculty of Education, School Management Centre SUPERVISOR: Mgr. Irena Lhotková, Ph.D. The Author of this bachelor work focuses on a problem starting a new teacher career. He deals with their point of view on the most difficult part of teacher's work, for example "reality shock", or relation with pupils'parents. The bachelor works is divided into theoretical part and practical part. The Theoretical part details the starting a new career in general and then applies this issue on teaching profession. The Practical part is the research part, the research was done using questionnaire surveys, classrom visits and interview with the starting teachers and teachers with long experience. The Practical part concludes some recommendations for starting teachers and even indicating teachers. KEYWODS: Career start, beginning teacher, indicating teacher, placing a new teacher
