1,721,133 research outputs found

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Use of yellow sticky traps to study daily flight activity and behaviour of sap-sucking insects inhabiting European vineyards

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    Yellow sticky traps are used to monitor sap-sucking insects in their roles as both pests and vectors across a broad range of crops including vineyards. They are also used to understand different aspects of insect biology, and for this purpose, a number of studies have been conducted to determine the daily flight activity of leafhoppers and thrips. In a vineyard in north-eastern Italy, the daily flight activities of leafhoppers [e.g. Empoasca vitis (Gothe), Zygina rhamni Ferrari, Scaphoideus titanus Ball], as well as the vine thrips Drepanothrips reuteri Uzel, were studied with yellow sticky traps during different monitoring days of the growing season. The traps were placed in both shady and sunny positions with respect to the grapevine foliage, and in inter-rows. They were routinely replaced every hour from the start of dawn to the end of dusk, while during the hours of darkness there was no replacement, except on one monitoring day. E. vitis, S. titanus and D. reuteri were mainly captured in sunny positions, while Z. rhamni was captured in shady positions. E. vitis exhibits bimodal daily flight activity with two peaks respectively at the dawn-sunrise and sunset-dusk. Z. rhamni prefers to fly around sunrise, when daily temperatures are lower, and S. titanus flies continuously from sunset to sunrise. The vine thrips flies only during sunshine hours. The daily hours with higher flight activity are mostly associated with changes in light intensity. The moderate light intensity that occurs immediately after sunrise and just before sunset inhibits the flight activity of leafhoppers outside the canopy but not inside. Knowing the daily flying activity and behaviour of leafhoppers and thrips can have important implications for establishing the optimal sampling time because in the hours of the highest flying activity counting adults can be more difficult

    Clinical relevance of pharmacokinetics and pharmacodynamics in cardiac critical care patients

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    Pharmacokinetics is a discipline aimed at predicting the best dosage and dosing regimen for each single drug in order to ensure and maintain therapeutically effective concentrations at the action sites. In cardiac critical care patients, various pathophysiological conditions may significantly alter the pharmacokinetic behaviour of drugs. Gastrointestinal drug absorption may be erratic and unpredictable in the early postoperative period, and so patients may be unresponsive to oral therapy; thus the intravenous route should be preferred for life-saving drugs whenever feasible. Variations in the extracellular fluid content as a response to the trauma of surgery and the fluid load or significant drug loss through thoracic drainages may significantly lower plasma concentrations of extracellularly distributed hydrophilic antimicrobials (β-lactams, aminoglycosides and glycopeptides). Drug metabolism may be altered by the systemic inflammatory response and/or multiple organ failure and/or drug-drug pharmacokinetic interactions that can potentially occur during polytherapy, especially in immunosuppressed cardiac transplant patients. Instability of renal function may promote significant changes in body fluid concentrations of renally eliminated drugs, even in a brief period of hours. Finally, the application of extracorporeal circulation by means of cardiopulmonary bypass may significantly alter the disposition of several drugs during the operation because of acute haemodilution, hypoalbuminaemia, hypothermia and/or adsorption to the bypass equipment. Accordingly, to avoid either overexposure and the consequent increased risk of toxicity or underexposure and the consequent risk of therapeutic failure in critically ill cardiac patients, the dosing regimens of several drugs are expected to be significantly different from those suggested for clinically stable patients. Additionally, therapeutic drug monitoring may be helpful in the management of drug therapy and should be routinely used to guide individualized dose adjustments for (i) immunosuppressants whenever cytochrome P450 3A4 isoenzyme inhibitors (e.g. macrolide antibacterials, azole antifungals) or inducers (e.g. rifampicin [rifampin]) are added to or withdrawn from the regimen; and (ii) glycopeptide and aminoglycoside antibacterials whenever haemodynamically active agents (such as dopamine, dobutamine and furosemide [frusemide]) are added to or withdrawn from the regimen, and also whenever significant changes of haemodynamics and/or of renal function occur. © 2008 Adis Data Information BV. All rights reserved

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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