1,721,350 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Abstract IA16: Targeting molecular chaperone and stress pathways to hit multiple hallmarks and overcome resistance
No full textAbstract
It is interesting and informative to review how the ‘Hallmarks' or Phenotypic Traits of cancers became codified and evolved over time. The original and now seminal ‘Hallmarks of Cancer' article by Hanahan and Weinberg (Cell 100 646-74 2000) codified the six classic—and now very well-known—Hallmark features. Next, Kroemer and Pouyssegur reassessed Tumor Cell Metabolism and discussed how alterations in this proposed seventh Hallmark are intertwined with cancer, either as cause or consequence (Cancer Cell 13 472-82 2008). Kroemer and Pouyssegur also highlighted Avoidance of Immunosurveillance as an additional element which would subsequently be incorporated as an eighth Hallmark. In 2011, a decade after their seminal article, Hanahan and Weinberg revisited their original Hallmarks, highlighting Genomic Instability and also the Inflammatory State that is driven by cells of the immune system as additional Hallmarks (Cell 144 646-74 2011). In addition, they emphasized the importance of the tumor microenvironment in cancer progression.
In the intervening period, meanwhile, Luo, Solimini and Elledge provided their own view of the expanded classic Hallmarks to include the Stress Phenotypes of Tumorigenesis. Moreover, they also set out their personal version of a revised conceptual framework for a combination of Oncogene and Non-Oncogene Addictions—with former concept having been promoted by Weinstein (Science 297 63-64 2002) and the latter by Luo et al themselves—and proposed how these contribute to the Cancer State. Of note they codified Metabolic Stress, Proteotoxic Stress, Mitototic Stress, Oxidative Stress and DNA Damage Stress into their overall model.
Running throughout the evolution of thinking about the Hallmarks of Cancer, captured and signposted by the above articles, is the concept that modern cancer therapies should be directed towards intervening with these key Phenotypic Traits. Luo et al emphasized that both Oncogene and Non-Oncogene Addictions could be exploited by either sensitizing cancer cells to stress or overloading stress-management pathways to selectively kill cancer cells. Of course the activity of bortezomib and other proteasome inhibitors in multiple myeloma—which is especially sensitive to proteotoxic stress overload owing to massive immunoglobin synthesis—is a poster child for this approach.
Over the last several years our lab and Unit have pursued various Non-Oncogene Addiction targets that could be classified as exploiting Proteotoxic Stress as a key feature of the Cancer State. In this talk, I will review and update our experience with inhibitors of the molecular chaperone HSP90, including discovery and clinical evaluation of luminespib or AUY 922 (Eccles et al Cancer Res 68 2850-60 2008; Polier et al Nat Chem Biol 9 307-312 2013; Samant et al PNAS 111 6834-9 2014; Smith et al Oncogene 34 15-26 2015; Ferraldeschi et al Cancer Res in press) and targeting HSP70 family members (Powers et al Cancer Cell 14 250-62 2008; Zhang et al Cancer Lett 339 49-59 2013; unpublished data). A particular current interest is in targeting the HSF1 pathway which, as with HSP90 inhibition, provides opportunities for hitting multiple Hallmarks and Vulnerabilities of the Cancer State and providing the potential to overcome cancer evolution and drug resistance (Workman et al Oncotarget 7 3658-61 2016). The challenge, however, is to find a way to drug this intractable ligand-less transcription factor (de Billy et al Cancer Cell 8 3806-8 2009). New unpublished data will be shown to illustrate targeting molecular chaperone and stress pathways to hit multiple Hallmarks of Cancer and overcome resistance, as part of a combinatorial approach to extend cancer survival and increase cure rates.
Citation Format: Paul Workman. Targeting molecular chaperone and stress pathways to hit multiple hallmarks and overcome resistance. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Targeting the Vulnerabilities of Cancer; May 16-19, 2016; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(1_Suppl):Abstract nr IA16.</jats:p
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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