1,720,970 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Understanding ubiquitin chain interactions and mechanisms of deubiquitinases
No full textZhuang, ZhihaoIn the past 15 years following the recognition of Ciechanover, Hershko, and Rose’s discovery of ubiquitin in signaling protein degradation, we have made much progress in understanding ubiquitination and deubiquitination as critical cellular signaling processes. Ubiquitination is catalyzed by a cascade of three enzymes (E1, E2 and E3) resulting in site- and linkage-specific ubiquitination of target protein. Deubiquitinases (DUBs) counter the ubiquitin ligases’ activity and reverse this process. It is increasingly realized that DUBs, in addition to linkage specificity to polyubiquitin chains, also exhibit target protein and site specificity. Understanding the source of linkage specificity is critical to understanding cellular signaling pathways including DNA damage response, immune response, and cell cycle progression. Dysregulation of the ubiquitin pathway enzymes are often associated with human diseases like cancer and neurological disorder. ☐ In Chapter 2, I detail the development and utilization of di- and tri-ubiquitin probes/ substrates in understanding DUB activity and specificity. I prepared both terminal and internal warhead-containing chemically linked diubiquitin probes. I generated a new terminal fluorophore-containing diubiquitin probe of K11, K48 and K63 linkages resistant to internal cleavage by DUBs. I also successfully generated hybrid triubiquitin probes bearing a chemical linkage through a non-cleavable or Michael acceptor-containing linker. Finally I created a heterotypic branched triubiquitin chain probes resistant to internal cleavage and containing a terminal warhead. These di-and tri-ubiquitin probes enabled extensive interrogation the linkage specificity of DUBs and polyUb chain reader proteins. ☐ In Chapter 3, I present proteomic study and identification of DUBs and reader proteins specific for branched ubiquitin probes from HEK-293T cell lysates. Branched ubiquitin chains represent a new frontier in understanding of polyubiquitin signaling in the cell with very little known about the roles and functions. These probes show some branched linkage specific to pathways like DNA damage response and mitophagy. While certain ubiquitin binding domains were shown to exhibit specificity to branched triubiquitin chains. ☐ In Chapter 4, I discuss the crystal structure of a USP family DUB, USP9X, catalytic core as well as the structural elements responsible for recognition of polyubiquitin chains of different linkages. Using polyubiquitin probes discussed in Chapter 1, we investigated the linkage dependent endo/exo cleavage selectivity of USP9X towards different polyubiquitin chains. Furthermore, we explore K11 diubiquitin binding dynamics to USP9X catalytic core through high resolution mass spectrometry demonstrating the power of activity-based polyubiquitin probes. ☐ Parts of chapter 2 and most of chapter 4 are adapted from texts and figures published in Paudel et. al. (2019). PNAS. 116(15) 7288-7297. Parts of chapter 2 also contain adapted text and figures from Gui et. al. (2019) Ref Mod Chem. Mol Sci Chem. 14672.University of Delaware, Department of Chemistry and BiochemistryPh.D
Leaf Essential Oil Composition of Citrus Japonica from Biratnagar, Nepal
Get PDFhttps://louis.uah.edu/rceu-hcr/1246/thumbnail.jp
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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