1,721,058 research outputs found
Mean and Outcomes
No full textThe article explores the role of research in architecture as an intermediate territory between science and art, emphasising the importance of expressive tools such as drawing, writing and typological comparison. Through the concept of ‘archaeology of the design process’, the author reflects on how method, subjectivity and context are indispensable elements in producing results that are original yet open to discussion. Architectural research is seen as a dynamic process, in which the comparison with existing cases and the conscious use of representative tools allow the construction of sharable knowledge that is never definitive
The Redesign of Social Housing Suburbs in Italy: Targeted Actions on Built Heritage
No full textThis research explores strategies for revitalizing decaying public housing neighborhoods in Italy through targeted architectural interventions that respect and adapt the existing built heritage. Emphasizing adaptability, social cohesion, and sustainability, it proposes a model applicable across Europe to respond to evolving social needs and urban transformations
Embryonic chick cocultures of neuronal and muscle cells
No full textObjective: The aim of this report was to set up an effective experimental model of cocultures between cells from spinal cord explants and myotubes from adductor muscle. Methods: We obtained neuronal cells from chick spinal cord explants at embryonic day 5 (ED5) by means of an enzymatic digestion. Small spinal cord fragments were added in cultured muscle cells committed to the differentiative program. Myoblasts were isolated from the chick adductor muscle at ED12. Results and discussion: The validation of the experimental model was confirmed by a remarkable spreading pattern of neuronal cells, labeled with a NF200 antibody, and high concentration of myotubes, marked by α-actinin antibody. The indication of neuronal contacts was highlighted by the α-bungarotoxin. This communication reports one of the few morphologic description of muscular and neuronal coculture preparation, performed on chick embryos. Conclusion: The experimental model presented in this work might be a useful tool to study the cascade of myogenic positive and negative signals activated by paracrine neuronal factors. © 2008 W. S. Maney & Son Ltd
Treatments of the injured tendons in Veterinary Medicine: From scaffolds to adult stem cells
No full textIn order to treat frequently occurring conditions such as traumatic rupture or over-strain tendinopathies, the techniques of tissue engineering and cell-based therapies have become an accepted modus operandi since other available remedies appear to be ineffective in restoring the original structure and function of the injured tissue. However, the mechanisms accounting for the effectiveness of novel regenerative approaches in treating equine tendon and ligament injuries remain poorly characterised. In this review we summarize and discuss the most significant results of our research regarding bioscaffold technology for treating complete tendon tears and the use of adult stem cells for treating tendon lesions induced by over-strain
Error pattern in an autistic savant calendar calculator
No full textSpecial ability in computing the day of the week from given dates was observed in a 18 years old male, L.E., suffering from autism. Neuropsychological testing revealed severe deficits in all cognitive domains and poor explicit knowledge of calendar structure. The subject scored well above the chance level on dates of the past and future decades. Error rate and response latency increased with temporal remoteness of dates. Most of errors were in indicating the weekday before or after that of date stimulus. The performance and error pattern suggest that L.E. used ‘‘encapsulated’’ computation algorithm(s) for the day of week task
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Hyaluronic acid, Manuka honey and Acemannan gel: Wound-specific applications for skin lesions
Full text linkHealing of open wounds is of great medical importance. Wound healing is a complex process that aims to restore the function and structure of damaged tissue. This study was conducted to compare secondary intention healing of wounds treated daily with a topical application of commercially available hyaluronic acid (HA), Manuka honey (MH), Acemannan gel (AG), or a placebo. Bilateral wounds were surgically created on the backs of six sheep. At two and six weeks post-wound creation, biopsies were obtained to perform histological, immunohistochemical, and molecular analyses of the wound site. Daily clinical evaluations were performed and weekly photographs were taken of the wounds. HA treatment promoted a physiological progression of the healing process in all wound healing phases, while stimulating an abundant cutaneous adnexa and promoting rapid healing, representing the most compelling treatment. MH-treated wounds were slightly dry. However, the main effect of MH was to promote cell proliferation and neovascularization, with an overall pro-inflammatory effect. Results suggest that MH treatment enhances the healing process. AG treatment dehydrated the wounds and stimulated late granulation tissue and cell proliferation. Moreover, AG-treated wounds produced a mild late pro-inflammatory and neovascularization effect. Our data indicate that AG treatment can have a positive influence on moist wounds with abundant granulation tissue and exudate
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