1,721,199 research outputs found
Sud: microstorie di una differente modernità : la penisola salentina: marginalità in movimento
No full textThe TGF-beta superfamily: a multitask signalling pathway for the animal kingdom
No full textThe TGF-β superfamily consists of numerous members, including TGF-β proper, bone morphogenetic proteins (BMP) and growth differentiation factors (GDF). All TGF-β are dimeric cytokines present a biological active carboxy terminal domain of 110–140 amino acids following proteolysis.
Bone morphogenetic proteins (BMPs), first identified for their involvement in vertebrate bone formation, are now widely recognized as key factors in the regulation of many fundamental developmental processes in all deuterostomes. The active gradient established by BMP secreted ligands is one of the essential factors responsible for generating the positional information that underlies developmental patterning, including the regeneration of lost parts.
Myostatin or GDF-8, a recently discovered GDF subfamily member, acts as a negative regulator in maintaining the mammalian proper muscle mass during both embryogenesis and post-natal muscle development. Unlike most other members of the BMP/GDF superfamily, mammalian myostatin is secreted as a latent complex, usually linked to regulatory proteins, and its mature dimer produces an effect almost exclusively on muscle tissue.
The present chapter deals with the importance of the TGF-β family of growth factors in relation to regulatory spheres through the animal kingdom, focusing in particular on the expression of BMP molecules during regeneration and myostatin in “non-canonical” animal models; it also focuses on the regulative actions of myostatin during the development of vertebrates and in different experimental conditions, including in vitro chick co culture and endurance training. Data available in literature indicate that there is substantial scope for future research in the area of TGF-β /myostatin linked to development
Novel strategies for tendon repair and regeneration: - Successful recellularization of human tendon scaffolds using adipose-derived mesenchymal stem cells - Use of adult stem cells and platlet-rich plasma in Veterinary Medicine
No full textLab Practicals of Veterinary Histology.
No full textPractical book of histology for Veterinary student
Effects of in vivo applications of peripheral blood-derived mesenchymal stromal cells (PB-MSCs) and platlet-rich plasma (PRP) on experimentally injured deep digital flexor tendons of sheep.
No full text
Regenerative strategies for different injuries of tendons: development of a biocompatible re-cellularized scaffold; in vivo treatment with MSCs and PRP in injured tendons
No full textThe major aim of regenerative medicine is to excogitate experimental techniques that take maximal advantage of reparative
processes that occur naturally in the animal body. Injection of mesenchymal stromal cells into the core of a damaged tendon
represents a form of seeding which aims to cope with the above statement. Here we present two different strategies to be
potentially used for i) tendon traumatic lesions and in ii) tendinitis.
i) In the first study we have developed a recellularized biocompatible scaffold from human tissue and our results show that it
is possible to introduce proliferating cells in the core of a decellularized tendon treating the scaffold with a collagen gel. This
method resulted efficient for maintaining the scaffold ECM and because of the expression of collagen type I and COMP by
injected mesenchymal stromal cells.
ii) In the second study we examined the use of autologous MSC derived from peripheral blood (PB-MSCs), platelet rich
plasma (PRP) and a combination of both for ameliorating experimental lesions on deep digital flexor tendons of sheep.
Effectiveness of treatments was evaluated at 30 and 120 days comparing clinical, ultrasonographic and histoimmunohistochemical
features. Significant differences were found between treated groups and their corresponding control
(placebo) regarding tendon morphology and extracellular matrix (ECM) composition. However, the results indicate that the
combined use of PRP and MSCs did not produce an additive or synergistic regenerative response and highlighted the
predominant effect of MSCs on tendon healing, enhanced tissue remodeling and improved structural organization
Cellule staminali derivate da sangue circolante e terapia delle tendiniti.
No full textIl mio seminario ha spiegato le nostre recenti ricerche sull'isolamento e caratterizzazione delle cellule staminali adulte da sangue
Peripheral blood stem cells and therapies of tendonitis.
No full textRelatore invitato al congresso per partecipare alla tavola rotonda intitolata: Attualità e prospettive dell’ingegneria tissutale in campo veterinari
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