54 research outputs found
Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders
No full textCannabinoids have a major therapeutic value in a variety of disorders. The concepts of cannabinoids are difficult to develop, but they can be used and are advantageous for a number of diseases that are not sufficiently managed by existing treatments. Nanoconjugation and encapsulation techniques have been shown to be effective in improving the delivery and the therapeutic effectiveness of drugs that are poorly soluble in water. Because the bioavailability of cannabinoids is low, the challenge is to explore different administration methods to improve their effectiveness. Because cannabinoids cross the blood-brain-barrier (BBB), they modify the negative effects of inflammatory processes on the BBB and may be a key factor in the improvement of BBB function after ischemic disease or other conditions. This review discusses various types of cannabinoid administration, as well as nanotechnologies used to improve the bioavailability of these compounds in CNS diseases
The neural underpinnings of the normative decision-making processes: A scoping review protocol
No full textThe current registration aims to preregister a scoping review focused investigating the Neuroscience of normative decision-makin
Algorithm for Internal State Financial Control by the Treasury of Russia: Problems and Solutions
No full textThe paper discusses an integrated research of implementing internal state financial control by the Federal Treasury. The aim of the study is to show the organization and stages (algorithm) of implementing internal state financial control, to identify problems and possible solutions. The relevance of the study determines the modern development of financial control, aimed at automation and digitalization. Scientific novelty is in systematizing problems of financial control and finding new solutions. The author uses methods of analysis, synthesis, induction, deduction, scientific abstraction, logical thinking, the dialectical method of cognition and observation. The study results in describing an algorithm for internal state financial control by the Treasury of Russia, and identifies problems (weaknesses) related to the planning and implementation of control measures in the financial and budgetary sphere, as well as possible solutions. The author points out the need to revise the procedures for implementing internal state financial control and its new forms with the current methods of financial control. The study suggests such a new form of financial control as automated remote financial monitoring, which warns on the impermissibility of violations in the financial and budgetary sphere. The author concludes that in order to automate and digitalize internal state financial control, it is necessary to create a unified information base, including systematized information according to the criteria set by the state. This will allow for a deeper economic analysis of using budgetary funds allocated by the state for certain purposes, at the stages of preliminary and subsequent control, that will improve and increase the efficiency of financial control, and save time and labor during control activities. The author recommends to improve the regulatory framework governing the implementation of financial control by the Russian Treasury, including internal state financial control
Melatonin stabilizes atherosclerotic plaques: an association that should be clinically sploited
No full textAuthor contributions:
RR: Conceptualization, Data curation, Formal analysis, Project administration, Supervision, Validation, Writing – original draft. RS: Data curation, Project administration, Software, Supervision, Visualization, Writing – review & editing. AR: Data curation, Validation, Writing – review & editing. FS: Data curation, Formal analysis, Writing – review & editing. AD-R: Data curation, Validation, Writing – review & editing. DC: Conceptualization, Formal analysis, Writing – review & editing.Atherosclerosis is the underlying factor in the premature death of millions of humans annually. The cause of death is often a result of the rupture of an atherosclerotic plaque followed by the discharge of the associated molecular debris into the vessel lumen which occludes the artery leading to ischemia of downstream tissue and to morbidity or mortality of the individual. This is most serious when it occurs in the heart (heart attack) or brain (stroke). Atherosclerotic plaques are classified as either soft, rupture-prone, or hard, rupture resistant. Melatonin, the production of which diminishes with age, has major actions in converting soft to hard plaques. Experimentally, melatonin reduces the ingrowth of capillaries from the tunica media into the plaque relieving pressure on the plaque, reducing intraplaque hemorrhage and limiting the size of the necrotic core. Moreover, melatonin promotes the formation of collagen by invading vascular smooth muscle cells which strengthen the plaque crown making it resistant to rupture.
Melatonin is also a powerful antioxidant and anti-inflammatory agent such that is reduces oxidative damage to tissues associated with the plaque and limits inflammation both of which contribute to plaque cap weakness. Additional benefits of melatonin relative to atherosclerosis is inhibition of adhesion molecules on the endothelial cell surface, limiting the invasion of monocytes into the arterial intima, and reducing the conversion of anti-inflammatory M2 macrophages to pro-inflammatory M1 macrophages. Given the high physiological and financial cost of cardiac and neural ischemic events, this information should be given high priority in the clinical settingDepto. de Farmacología y ToxicologíaFac. de VeterinariaTRUEpu
Decreasing linguistic complexity within a sixth grade mathematics middle school curriculum: a project.
No full textThe author investigated how a school's in-use mathematics curriculum could be adapted to become less linguistically complex for English language learners. In past studies, only mathematics test items were manipulated to reduce linguistic complexity. Drawing from past studies and implementing past ideas into the mathematics curriculum, the adaptions produced a less linguistically complex curriculum. The findings suggest future research and reduction of linguistic complexity within a curriculum. The findings also suggest implementation of curriculum.SUNY at Fredoni
Porcine circovirus 2 inclusion bodies in pulmonary and renal epithelial cells
No full textPorcine circovirus 2 (PCV2) is the cause of postweaning multisystemic wasting syndrome (PMWS). The most common lesions of PMWS are lymphohistiocytic to granulomatous lymphadenitis, interstitial pneumonia and interstitial nephritis, with intracytoplasmic amphophilic botryoid inclusion bodies in macrophages. In addition to these typical changes, intracytoplasmic botryoid Inclusion bodies were observed in bronchial, bronchial glandular, and renal tubular epithelium of several pigs from 4 different farms in Western and Eastern Canada. PCV2 inclusion bodies were demonstrated to be located in the cytoplasm of epithelial cells by immunohistochemical staining for PCV2 and cytokeratin antigens and by ultrastructural demonstration of viral particles in the inclusion bodies within renal tubular epithelium
IdeTo: Spreadsheets for Calculation and Analysis of Area Under the Disease Progress Over Time Data
No full textWhen disease ratings are obtained over time, area under the disease progress metrics such as area under the disease progress curve (AUDPC) and area under the disease progress stairs (AUDPS), which allow integration of these measures into a single value, have found use for both survey or replicated experiment data. IdeTo, an Excel-based calculator, computes AUDPC, AUDPS, and their standardized and relative values for up to 200 individuals evaluated at 200 timepoints. In addition to the areas, descriptive statistics are provided for the group of individuals (e.g., accessions and replicates), and both Pearson and Spearman correlation coefficients between the areas and other traits of interest. Graphs are provided to visualize the progression of disease scores over time, distribution of AUDPC and AUDPS values in the dataset, and their linear correlation with the traits of interest.[Figure: see text] The author(s) have dedicated the work to the public domain under the Creative Commons CC0 “No Rights Reserved” license by waiving all of his or her rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law, 2021
Алгоритм осуществления внутреннего государственного финансового контроля Казначейством России: проблемы и пути решения
No full textThe paper discusses an integrated research of implementing internal state financial control by the Federal Treasury. The aim of the study is to show the organization and stages (algorithm) of implementing internal state financial control, to identify problems and possible solutions. The relevance of the study determines the modern development of financial control, aimed at automation and digitalization. Scientific novelty is in systematizing problems of financial control and finding new solutions. The author uses methods of analysis, synthesis, induction, deduction, scientific abstraction, logical thinking, the dialectical method of cognition and observation. The study results in describing an algorithm for internal state financial control by the Treasury of Russia, and identifies problems (weaknesses) related to the planning and implementation of control measures in the financial and budgetary sphere, as well as possible solutions. The author points out the need to revise the procedures for implementing internal state financial control and its new forms with the current methods of financial control. The study suggests such a new form of financial control as automated remote financial monitoring, which warns on the impermissibility of violations in the financial and budgetary sphere. The author concludes that in order to automate and digitalize internal state financial control, it is necessary to create a unified information base, including systematized information according to the criteria set by the state. This will allow for a deeper economic analysis of using budgetary funds allocated by the state for certain purposes, at the stages of preliminary and subsequent control, that will improve and increase the efficiency of financial control, and save time and labor during control activities. The author recommends to improve the regulatory framework governing the implementation of financial control by the Russian Treasury, including internal state financial control.Статья посвящена комплексному исследованию процесса осуществления Федеральным казначейством внутреннего государственного финансового контроля. Цель исследования — показать организацию и этапы (алгоритм) осуществления внутреннего государственного финансового контроля, выявить проблемные вопросы и возможные пути их решения. Актуальность исследования определяет современное развитие финансового контроля, направленное на использование процессов автоматизации и цифровизации. Научная новизна заключается в систематизации проблем в области финансового контроля и в поиске новых путей их решения. Автор использует такие методы, как анализ, синтез, индукция, дедукция, метод научной абстракции, метод логического мышления, диалектический метод познания и метод наблюдения. В результате описан алгоритм осуществления Казначейством России внутреннего государственного финансового контроля, выявлены проблемы (слабые места) в осуществлении процедур, связанных с планированием, проведением и реализацией контрольных мероприятий в финансово-бюджетной сфере, а также возможные пути их решения. Автор указывает на необходимость пересмотра процедур осуществления внутреннего государственного финансового контроля и внедрения новых форм контроля при существующих методах финансового контроля. Предложена новая форма финансового контроля в виде автоматизированного дистанционного финансового мониторинга, сущность которого заключается в предупреждении о недопустимости совершения нарушений в финансово-бюджетной сфере. Автор пришел к выводу, что для автоматизации и цифровизации внутреннего государственного финансового контроля необходимо создать единую информационную базу, включающую систематизированную информацию по заданным государством критериям. Это позволит проводить более глубокий экономический анализ использования бюджетных средств, выделяемых государством на определенные цели, на стадиях предварительного и последующего контроля, что приведет к совершенствованию и повышению эффективности финансового контроля, позволит экономить время и трудозатраты при проведении контрольных мероприятий. В качестве рекомендаций автором обращено внимание на необходимость совершенствования нормативноправовой базы, регулирующей осуществление финансового контроля, в том числе внутреннего государственного финансового контроля, Казначейством России
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