6,212 research outputs found
Environmental economics and the Murray-Darling river system
No full textMuch concern about the negative environmental consequences of agricultural development in Australia, including salinisation, waterlogging and algal blooms, has focused on the problems of the Murray–Darling Basin. The aim of this article is to provide an overview of the environmental problems of the Murray–Darling Basin from an economic perspective, and a selective survey of the relevant economic literature, including theoretical analysis, modelling and contributions to the development of water policy. In attempting to understand the complex problems of the Murray–Darling Basin, an eclectic approach drawing on externality, sustainability and property rights perspectives seems most appropriate.Environmental Economics and Policy, Resource /Energy Economics and Policy,
The Ghost of Patrick Geddes: Civics As Applied Sociology
No full textIn 1904 and 1905 Patrick Geddes (1905, 1906) read his famed, but today little-read, two-part paper, \'Civics: as Applied Sociology\', to the first meetings of the British Sociological Society. Geddes is often thought of as a \'pioneer of sociology\' (Mairet, 1957; Meller, 1990) and for some (eg Devine, 1999: 296) as \'a seminal influence on sociology\'. However, little of substance has been written to critically assess Geddes\'s intellectual legacy as a sociologist. His work is largely forgotten by sociologists in Britain (Abrams, 1968; Halliday, 1968; Evans, 1986). Few have been prepared to follow Geddes\'s ambition to bridge the chasm between nature and culture, environment and society, geography, biology and sociology. His conception of \'sociology\', oriented towards social action from a standpoint explicitly informed by evolutionary theory. A re-appraisal of the contemporary relevance of Geddes\'s thinking on civics as applied sociology has to venture into the knotted problem of evolutionary sociology. It also requires giving some cogency to Geddes\'s often fragmentary and inconsistent mode of address. Although part of a post-positivist, \'larger modernism\' Geddes remained mired in nineteenth century evolutionary thought and fought shy of dealing with larger issues of social class or the breakthrough work of early twentieth century sociology of Simmel, Weber and Durkheim. His apolitical notion of \'civics\' limits its relevance to academic sociology today.History of Sociology, Civics, Patrick Geddes, Scottish Generalism, Urban Sociology
Educational Developmentalists Divided? Patrick Cannon, Patrick Hillery and the Economics of Education in the Early 1960s
No full textThe catalytic effect of the OECD-linked study that produced Investment in Education is a much celebrated episode of Ireland’s modernisation. A remarkably broad cross-departmental consensus supported the initiative. Bureaucratic caution and ministerial self-preservation were set aside to allow a “warts and all” portrait of Irish education to be painted by the study team. Special efforts were made to focus public attention on the findings of a damning report that legitimated a quickening pace of government action to increase access to an expanded, rationalised and reoriented education system. But, as well as developmentalist triumph over conservatism in the education field, there was also significant division between state and civil society developmentalists. This is examined through an analysis of the relationship between the Federation of Lay Catholic Secondary Schools and the Department of Education.
History of the war in the Peninsula and in the south of France, from the year 1807 to the year 1814.
No full textImprint varies: v. 1 published by John Murray. v. 2-6 published by T. & W. Boone.Mode of access: Internet
The Cadet, 1915-03, no. 04
No full textThe Cadet was published between 1914-1924 as an enterprise for the benefit of the Catholic Cadet Corps. A non-political publication, it covers a wide range of subjects of general interest, including the activities not only of the C.C.C., but of other Newfoundland cadet corps as well.Editorial -- Standing together / J. T. Steading -- Partnership -- Recollections of Earl Kitchener / Sir Edward Morris -- Enlisting in Ireland / A.T.R. -- The Irish in Newfoundland in the 19th Century, article III : Patrick Morris / P. K. Devine -- Gold nuggets -- Gerald Griffin / M. P. Gibbs -- The conqueror -- A challenge to Prussian “tradition” : why Germany hated England / Anthony Hope -- Dates in history -- President W.D. Reid's contribution to the war -- Our honoured dead : first list, lost on cruiser Vicnor ; second list, lost on cruiser Clan McNaughton ; third list, lost on cruiser Bayano -- Officers of the First Newfoundland Regiment [illustration] -- Officers, N.C.O.'s and men of the First Newfoundland Regiment who embarked by S.S. “Dominion,” February 16, 1915 -- The happiest man in the world / J. M. Devine -- Be careful how you drink milk -- Our naval losses -- The sealing voyage, 1915 -- Have a hobby! / Randolph Murray -- Blowing up your skin : administering oxygen -- You eat more if you’re thin.Frequency: quarterly (?). Includes numerous advertisements
SimQuest, Authoring educational simulations
No full textJoolingen, W.R. van, & Jong, T.de (2003). SimQuest, authoring educational simulations. In: T. Murray, S. Blessing, S. Ainsworth: Authoring Tools for Advanced Technology Learning Environments: Toward cost-effective adaptive, interactive, and intelligent educational software. pp. 1-31. Dordrecht: Kluwer.SIMQUEST is an authoring system for creating computer simulations embedded in an instructional environment. A typical learning environment created with SIMQUEST allows learners to engage in an activity of discovery learning with a simulation, supported by instructional measures from within the environment. Some of these instructional measures adapt themselves to the interaction of the learner with the simulation. SIMQUEST allows the author to create various kinds of instructional support for the learner. Assignments provide the learner with short term goals for the learning process, explanations offer additional information, a monitoring tool allows the learner to record and replay experiments, and, moreover, the domain can be arranged according to different levels of model progression. Recent developments are a hypothesis scratchpad, intelligent feedback, a modelling tool, and facilities for collaborative learning in SIMQUEST. SIMQUEST supports the full process of authoring simulation based learning environments, from creating the simulation model to defining the instructional interaction of the learning environment with the learner. Authoring a SIMQUEST learning environment is done in an object oriented way. The author selects templates from a library to create building blocks of the learning environment, which are then edited to match the author's requirements. The SIMQUEST architecture, with a simulation context as central element takes care of the interaction between the various building blocks. The author is supported by the contents of the library, on-line help, on-line pedagogical advice, and a wizard that can automate part of the authoring process. SIMQUEST has been used to create about twenty learning environments, some of which have been evaluated extensively with students. Currently SIMQUEST is used by a group of teachers to create learning material for use in their classrooms. A number of SIMQUEST learning environments are now published by commercial publishers
Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury. A Randomized Clinical Trial
No full textImportance: Sepsis-associated acute kidney injury (AKI) adversely affects long-term kidney outcomes and survival. Administration of the detoxifying enzyme alkaline phosphatase may improve kidney function and survival.
Objective: To determine the optimal therapeutic dose, effect on kidney function, and adverse effects of a human recombinant alkaline phosphatase in patients who are critically ill with sepsis-associated AKI.
Design, setting, and participants: The STOP-AKI trial was an international (53 recruiting sites), randomized, double-blind, placebo-controlled, dose-finding, adaptive phase 2a/2b study in 301 adult patients admitted to the intensive care unit with a diagnosis of sepsis and AKI. Patients were enrolled between December 2014 and May 2017, and follow-up was conducted for 90 days. The final date of follow-up was August 14, 2017.
Interventions: In the intention-to-treat analysis, in part 1 of the trial, patients were randomized to receive recombinant alkaline phosphatase in a dosage of 0.4 mg/kg (n = 31), 0.8 mg/kg (n = 32), or 1.6 mg/kg (n = 29) or placebo (n = 30), once daily for 3 days, to establish the optimal dose. The optimal dose was identified as 1.6 mg/kg based on modeling approaches and adverse events. In part 2, 1.6 mg/kg (n = 82) was compared with placebo (n = 86).
Main outcomes and measures: The primary end point was the time-corrected area under the curve of the endogenous creatinine clearance for days 1 through 7, divided by 7 to provide a mean daily creatinine clearance (AUC1-7 ECC). Incidence of fatal and nonfatal (serious) adverse events ([S]AEs) was also determined.
Results: Overall, 301 patients were enrolled (men, 70.7%; median age, 67 years [interquartile range {IQR}, 59-73]). From day 1 to day 7, median ECC increased from 26.0 mL/min (IQR, 8.8 to 59.5) to 65.4 mL/min (IQR, 26.7 to 115.4) in the recombinant alkaline phosphatase 1.6-mg/kg group vs from 35.9 mL/min (IQR, 12.2 to 82.9) to 61.9 mL/min (IQR, 22.7 to 115.2) in the placebo group (absolute difference, 9.5 mL/min [95% CI, -23.9 to 25.5]; P = .47). Fatal adverse events occurred in 26.3% of patients in the 0.4-mg/kg recombinant alkaline phosphatase group; 17.1% in the 0.8-mg/kg group, 17.4% in the 1.6-mg/kg group, and 29.5% in the placebo group. Rates of nonfatal SAEs were 21.0% for the 0.4-mg/kg recombinant alkaline phosphatase group, 14.3% for the 0.8-mg/kg group, 25.7% for the 1.6-mg/kg group, and 20.5% for the placebo group.
Conclusions and relevance: Among patients who were critically ill with sepsis-associated acute kidney injury, human recombinant alkaline phosphatase compared with placebo did not significantly improve short-term kidney function. Further research is necessary to assess other clinica
The Life And Opinions Of Tristram Shandy, Gentleman
No full textVerfasser ermittelt nach ESTCDie Rückseite des Titelblatts ist unbedrucktDas Frontispiz ist ein Kupferstich, unterzeichnet: "Published as the Act directs. Jany. 14th. 1780. by W. Strahan, T. Cadell, J. Dodsley, G. Robinson & J. Murray. &c."Enthält Widmungen an: "... To A Great Man", unterzeichnet: "... The Author" und "To The Right Honourable John Lord Viscount Spencer ...", unterzeichnet: "... Laur. Sterne."Vorlageform der Veröffentlichungsangabe: London: Printed for W. Strahan, J. Dodsley, G. Robinson, T. Cadell, T. Lowndes, and J. Murray. MDCCLXXXII
The Life And Opinions Of Tristram Shandy, Gentleman
No full textVerfasser ermittelt nach ESTCMit Frontispiz (Kupferstich), unterzeichnet: "W. Hogarth invt." und "J. Collyer sculpt." und einer Darstellung eines schwarzen Rechtecks auf den Seiten 67-68 (Holzschnitt)Enthält Widmung an: "To The Right Honourable Mr. Pitt", unterzeichnet: "... The Author."Vorlageform der Veröffentlichungsangabe: London: Printed for W. Strahan, J. Dodsley, G. Robinson, T. Cadell, T. Lowndes, and J. Murray. MDCCLXXXII
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