189 research outputs found

    Personality patterns and duodenal ulcer relapse under antisecretory treatment

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    The personality pattern of duodenal ulcer (DU) patients on maintenance treatment who relapsed (N = 22) was compared to a similar group who did not relapse (N = 57) using the Sixteen Personality Factors Questionnaire Multivariate analysis of data indicated that a subgroup of DU patients with personality marked by dependent and anxiety traits was more prone to relapse of illness. </jats:p

    Corrigendum to “The 2016 update of the International Study Group (ISGPF) definition and grading of postoperative pancreatic fistula: eleven years after.” Surgery 2017. Mar; 161 (3):584–591. Epub Dec 28, 2016 (Surgery (2017) 161(3) (584–591), (S0039606016307577), (10.1016/j.surg.2016.11.014))

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    The authors regret that the name of author Charles R. Vollmer MD is incorrect in the final published version. The correct name Charles Vollmer. The authors would like to apologise for any inconvenience caused. Below is the correct order of authors: Claudio Bassi, MDa, Giovanni Marchegiani, MDa, Christos Dervenis, MD,b, Micheal Sarr, MDc, Mohammad Abu Hilal, MDd, Mustapha Adham, MDe, Peter Allen, MDf, Roland Andersson, MDg, Horacio J. Asbun, MDh, Marc G. Besselink, MDi, Kevin Conlon, MDj, Marco Del Chiaro, MDk, Massimo Falconi, MDl, Laureano Fernandez-Cruz, MDm, Carlos Fernandez-del Castillo, MDn, Abe Fingerhut, MDo, Helmut Friess, MDp, Dirk J Gouma, MDi, Thilo Hackert, MDq, Jakob Izbicki, MDr, Keith D. Lillemoe, MDn, John P. Neoptolemos, MDs, Attila Olah, MDt, Richard Schulick, MDu, Shailesh V. Shrikhande, MDv, Tadahiro Takada, MDw, Kyoichi Takaori, MDx, William Traverso, MDy, Charles Vollmer, MDz, Christopher L. Wolfgang, MDaa, Charles J. Yeo, MDbb, Roberto Salvia, MDa, Marcus Buchler, MDq, from the International Study Group on Pancreatic Surgery (ISGPS

    Synthesis and anticancer activity of selenium-substituted dinucleoside tetraphosphate analogues

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    Colorectal cancers (CRCs) which have elevated expression of the nucleotide pool cleanser dUTPase have been found to have increased resistance to thymidylate synthase (TS) inhibitors such as 5-fluorouracil (5-FU) and this enzyme is therefore an attractive target for potentiating anticancer activity of chemotherapy.[1] dUTPase catalyses the hydrolytic cleavage of the anhydride bond between the - and -phosphoryl moieties and following the demonstration of rAp4dU as a substrate of dUTPase,[2] we prepared a novel, selenium-substituted symmetric 5,5-dinucleoside tetraphosphate P4-SedU2 (1 Figure 1 A) using mechanochemistry. Figure 1. A Structure of selenium-substituted dinucleoside tetraphosphate substrate of dUTPase. B Tumour volume plot of mice treated with: untreated (); 1 - 1.5 mg/kg ( RALA/1 - 1.5 mg/kg (). ); 2:1 Remarkably treatment of HCT116 CRC xenografted BALB/c SCID mice with 1 formulated with the amphipathic peptide RALA (H-WEARLARALARALARHLARALARALRACEA-OH) Male mice showed significant activity in controlling cancer growth. [3] References: [1] Vértessy, B. G.; Tóth, J., Acc. Chem. Res 2009, 42, 97-106. [2] Ji, D. B., Beharry, A. A., Ford, J. M., Kool, E. T., J. Am. Chem. Soc. 2016, 138, 9005-9008. [3] Wilson, J. J., Bennie, L., Eguaogie, O., Elkashif, A., Conlon, P. F., Jena, L., McErlean, E., Buckley, N.; Englert, K.; Dunne, N. J.; Tucker, J. H. R.; Vyle, J. S.; McCarthy, H. O., JCR 2024, 369, 63-7

    Hypergraph expanders of all uniformities from Cayley graphs

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    Hypergraph expanders are hypergraphs with surprising, non‐intuitive expansion properties. In a recent paper, the first author gave a simple construction, which can be randomized, of 3‐uniform hypergraph expanders with polylogarithmic degree. We generalize this construction, giving a simple construction of r‐uniform hypergraph expanders for all r ⩾ 3

    Control of Finite-Dimensional Quantum Systems under Lindblad Dissipation.

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    This thesis considers the problem of controlling finite-dimensional quantum density matrices under the influence of Lindblad dissipation. The primary insight is that, when one assumes arbitrary Hamiltonian control, we can project the Lindblad equation onto a set of differential equations over the set of orbits. These new control equations are valid only on the interior of the orbit set, but we have shown that controllability results on enlarged sets can safely be applied to this interior. We provide a thorough controllability analysis for arbitrary two-dimensional systems and show that every system has a trap, inside of which one has full controllability, but from which a system cannot escape. We also provide a result classifying purifiable two-dimensional systems. For higher dimensional systems, we can also project the Lindblad equation to differential equations on the interior of the set of orbits. We have studied a reduced control problem where one considers only a set of n!n! controls that are generated by the symmetric group SnS_n. We can construct sets of small-time local controllability for arbitrary dimensions, and have provided some results on global controllability for three dimensions. Finally, we have provided two combinatorial formulas relating certain points on the STLC set for three dimensions to rooted trees. One of these formulas has been shown to generalize to higher dimensions.PhDApplied and Interdisciplinary MathematicsUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/93810/1/dprooney_1.pd

    Extreme ultraviolet emission lines of Ni XII in laboratory and solar spectra

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    Wavelengths for emission lines arising from 3s23p5-3s3p6 and 3s23p5-3s23p43d transitions in Ni XII have been measured in extreme ultraviolet spectra of the Joint European Torus(JET) tokamak. The 3s23p5 2P1/2-3s23p4(3P)3d 2D3/2 line is found to lie at 152.90 ± 0.02 A, a significant improvement over the previous experimental determination of 152.95 ± 0.5 A. This new wavelength is in good agreement with a solar identification at 152.84 ± 0.06 A, confirming the presence of this line in the solar spectrum. The Ni XII feature at 152.15 A may be a result only of the 3s23p5 2P3/2-3s23p4(3P)3d 2D5/2 transition, rather than a blend of this line with 3s23p5 2P3/2-3s23p (3P)3d 2P1/2, as previously suggested. Unidentified emission lines at 295.32 and 317.61 A in solar flare spectra from the Skylab mission are tentatively identified as the 3s23p5 2P3/2-3s3p6 2S1/2 and 3s23p5 2P1/2-3s3p6 2S1/2 transitions in Ni XII, which have laboratory wavelengths of 295.33 and 317.50 A, respectively. Additional support for these identifications is provided by the line intensity ratio for the solar features, which shows good agreement between theory and observation

    UNLOCKING THE AFFECTIONS IN J.S. BACH’S FLUTE SONATA IN E MINOR, BWV 1034

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    This document explores the affects of—or the use of emotions in—J. S. Bach’s Sonata for Flute in E minor, BWV 1034, by examining for potential connections Bach’s cantatas that were written contemporaneously. In the fall of 1724, Bach suddenly began writing extensive flute obbligato parts in the arias of many of his cantatas. It is believed that a visiting flutist of some skill and proficiency resided in Leipzig during this period and may have inspired these cantata parts as well as the Sonata for Flute in E minor, BWV 1034. Each movement of the Sonata is compared to the flute parts in the arias of the cantatas— as well as other movements from the cantatas— for similarities in key, tempo, meter, style, and motive. The author discovers associations between these characteristics in the Sonata and Cantatas BWV 94, 114, 130, and 46. The musical relationships and the affects they portray are determined between the cantatas and the Sonata, the cantata librettos, as well as the additional liturgical readings that support the themes of these cantatas. These passages provide textual imagery and inspiration for interpreting the emotions of the individual movements of the Sonata

    Extensions of the Krull-Schmidt-Azumaya Theorem

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    Title: Extensions of the Krull-Schmidt-Azumaya Theorem, Author: Ronald W. Richards, Location: ThodeThe question which promoted this dissertation is the following: "How unique is a direct sum decomposition of a given R-module?" The classical result is tho direction is the so-called Krull-Schmitd-Azumaya Theorem, proved by Gorô Azumaya in [1]. It gives an answer to the question in the case that the given R-module is a direct sum of the sub-modules with local endomorphism ring. It is generalizations and extensions of this theorem that this paper is concerned with. The results of this thesis are stated and proved in a more general categorical setting than mod-R. Moreover, we do not resort to the embedding theorem, with the idea in mind that further generalization in those categories we are considering and similar results in other sort of categories may be suggested. Chapter I lays some necessary categorical ground-work. In Chapter 2 we combine results of S. B. Conlon [2] and S. Elliger [4] within our categorical setting to obtain a generalization of the Krull-Schmidt-Azumaya Theorem. We consider representations of an object as an essential extension of a direct sum of summands (rather than simply direct sum decompositions), and we allow certain summands other than those with local endomorphism ring. Chapter 3, follow [10], (which was in turn applying the results of [3]) extends the concept of "local endomorphism ring" to the concept of "the exchange property" and produces certain coproduct uniqueness theorems. Finally, in Chapter 4, we consider decomposition of injectives and we see that certain problems involving coproduct decompositions can be eliminated in the case where the objects concerned are injective. We present a uniqueness theorem due to R.B. Warfield [10] and draw conclusions from this with the aid of the "spectral category" (which will be define and examined).ThesisMaster of Science (MS

    Environmental correlates of blue and fin whale call detections in the North Pacific Ocean from 1997 to 2002

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    Author Posting. © Inter-Research, 2009. This article is posted here by permission of Inter-Research for personal use, not for redistribution. The definitive version was published in Marine Ecology Progress Series 395 (2009): 37-53, doi:10.3354/meps08362.A 6 yr time series of blue whale Balaenoptera musculus and fin whale B. physalus call detections in the North Pacific Ocean was correlated with 3 oceanographic variables (sea-surface temperature, chlorophyll a concentration, and mixed layer depth), to investigate the broad-scale calling behavior of these species. Monthly values for satellite-derived oceanographic data and whale call data were compared for 4 regions (30° longitude by 15° of latitude) encompassing the whole subarctic North Pacific and an area in the temperate northeastern Pacific. To determine predictive models for whale call occurrence, generalized linear models were used to determine which, if any, oceanographic variables might influence whale calling behavior over such broad space and time scales. Sea-surface temperature was the best oceanographic variable for predicting whale call detections for both species and all regions.Funding over the years was provided by SERDP through SPAWAR (D. Conlon), the Marine Mammal Program of the Office of Naval Research (R. Gisiner, N00014- 96-1-1130), the Chief of Naval Operations Environmental Program N45 (F. Stone and E. Young), the US Army Corps of Engineers (DCA87-00-H-0026), funding from the Department of Defense Legacy Resource Management Program and from the Naval Postgraduate School (C. Collins, N00244-07-1-0017 to K.M.S. and N00244-07-1-0014 to M.A.D.)

    Behavioral Aspects of Bargaining and Pricing.

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    Some remarkable results of the studies in this thesis are that individual behavior seems to be rather well described by theories taking the (im)patience of agents into account. Fairness considerations are found to play an important role not only in bargaining situations but also in competitive markets. At the same time, the impact of fairness varies with the institutional setting. Finally, investigation into the variation of trust accross the Dutch population suggests that age and education affect a basic trust propensity.
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