337 research outputs found
Synthesis of PNA-Peptide Conjugates as Functional SNARE Protein Mimetics
No full textPNA-peptide conjugates are versatile tools in chemical biology, which are employed in a variety of applications. Here, we present the synthesis of PNA-peptide conjugates that serve as SNARE protein-mimicking biooligomers. They resemble the structure of native SNARE proteins but exhibit a much simpler architecture. Incorporated into liposomes, they induce lipid mixing, so that they can be used to study the SNARE-mediated membrane fusion in a simplified setting in vitro. They consist of artificial SNARE recognition units made out of PNA oligomers, which are attached to the native linker and transmembrane domains of two neuronal SNAREs. The PNA-peptide conjugates are synthesized via solid-phase peptide synthesis in a continuous fashion starting with the peptide part, followed by assembly of the PNA recognition unit. On top, we describe a strategy to synthesize PNA-peptide conjugates in a fully automated fashion by using a peptide synthesizer.
A Description of Figurative Speech in Idina Menzel Selected Song
No full textThis paper is entitled “Description of Figurative Speech in Idina Menzel Selected Song”.
This paper aims to find the types of figurative speech contained in Idina Menzel's selected
songs in her album named Idina, and find the dominant figurative speech used in the songs.
The research method that the author used is the descriptive method or qualitative research
using the theory of Gorys Keraf (2007). From this research, the authors found four types of
figurative speech used in five selected songs by Idina Menzel with two types of figurative
speech dominating. The four kinds of figurative are hyperbole, simile, repetition, and
personification. And the dominant type of figurative speech used is Hyperbole and Simile.56 HalamanKertas Karya Diplom
Microdarwinula zimmeri Menzel 1916, n. sp.
No full text<i>Microdarwinula zimmeri</i> (Menzel, 1916) <p>(Figs 9 F–H)</p> <p> 1916 <i>Darwinula zimmeri</i> n. sp. —Menzel: 487–489, Figs 16, 17.</p> <p> 1952 <i>Darwinula brevis</i> n. sp. —Straub: 498, text-figs 21–22.</p> <p> <i>nov. comb.</i> 1969 <i>Microdarwinula zimmeri</i> (Menz) —Danielopol: 154–163, figs 1–28.</p> <p> <b>Material examined.</b> Seven females from a seep at the edge of a track in Hino-cho, Shiga Prefecture, N35º 00’ 02.1”, E136º 19’ 32.2”, 16 April 2008. One female from gravel in the riverbed of the Myo-odani River, Katsuragawabomura-cho, Otsu, Shiga Prefecture, N35º 14’ 38.3”, E135º 52’ 19.9”, 4 October 2007. All material collected by the author.</p> <p> <b>Remarks.</b> Previous records of <i>Microdarwinula zimmeri</i> are widespread, but sparsely distributed in Europe, Western Africa, North America, the Caribbean, Madagascar, the Middle East and Indonesia (see the review in Rossetti and Martens 1998). Herein is the first report of this species from Japan.</p>Published as part of <i>Smith, Robin J., 2011, Groundwater, spring and interstitial Ostracoda (Crustacea) from Shiga Prefecture, Japan, including descriptions of three new species and one new genus, pp. 15-37 in Zootaxa 3140</i> on page 34, DOI: <a href="http://zenodo.org/record/207945">10.5281/zenodo.207945</a>
Coherent Fourier scatterometry reveals nerve fiber crossings in the brain
No full textPrevious simulation studies by Menzel et al. [Phys. Rev. X 10, 021002 (2020)] have shown that scattering patterns of light transmitted through artificial nerve fiber constellations contain valuable information about the tissue substructure such as the individual fiber orientations in regions with crossing nerve fibers. Here, we present a method that measures these scattering patterns in monkey and human brain tissue using coherent Fourier scatterometry with normally incident light. By transmitting a non-focused laser beam (λ = 633 nm) through unstained histological brain sections, we measure the scattering patterns for small tissue regions (with diameters of 0.1–1 mm), and show that they are in accordance with the simulated scattering patterns. We reveal the individual fiber orientations for up to three crossing nerve fiber bundles, with crossing angles down to 25°
Mundos posibles y paradojas
No full textRobert Adams' definition of a possible world is paradoxical according to Selmer Bringsjord, Patrick Grim and, more recently, Cristopher Menzel. The proofs given by Bringsjord and Grim relied crucially on the Powerset Axiom; Christoper Menzel showed that, while this continued tobe the case, there was still hope for Adams' definition, but Menzel he undustedan old russellian paradox in order to prove that we could obtain the same paradoxical consequences without appealing to any other set theory than the Axiomof Separation. Nevertheless, Menzel's result only showed that there was no actualworld. In this paper we try to generalize Russell's paradox to arbitrary possible worlds without introducing an irreducible modal component in the discussion.La definición de un “mundo posible” de Robert Adams es paradójica, de acuerdo con Selmer Bringsjord, Patrick Grim y Cristopher Menzel. Las pruebas de Bringsjord y Grim utilizaban el axioma del Conjunto Potencia; Cristopher Menzel objetó que, mientras este fuese el caso, todavía existía esperanza para la definición de Adams, pero Menzel desempolvó una vieja paradoja de Russell para demostrar que podíamos obtener las mismas conclusiones sin apelar a otra teoría de conjuntos que el Axioma de Separación. Sin embargo, el resultado de Menzel mostraba solo que no existía el mundo actual. En este trabajo intentamos generalizar la paradoja de Russell a mundos posibles arbitrarios sin necesidad de introducir conceptos modales en la discusión
Towards high-speed computational scattered light imaging by introducing compressed sensing for optimized illumination
No full textWe propose the application of Compressed Sensing to Computational Scattered Light Imaging to decrease measurement time and data storage. Computational Scattered Light Imaging (ComSLI) determines three-dimensional fiber orientations and crossings in biomedical tissues like brain tissue. Currently, conventional ComSLI is time-consuming and generates large data. Compressed Sensing reconstructs signals with fewer samples than required by the Shannon-Nyquist theorem with minimal perceptual loss, significantly reducing the number of measurements. We introduce an optimized illumination strategy for ComSLI based on the Discrete Cosine Transform and validate it by reconstructing characteristic scattering patterns in vervet brain tissue, thereby demonstrating the feasibility of Compressed Sensing in ComSLI.ImPhys/Menzel grou
5-HTTLPR genotype influences amygdala volume
No full textFunctional imaging studies in healthy individuals revealed an association between 5-HTTLPR genotype and neuronal activity in the amygdala. The aim of this study was firstly to investigate a possible overall impact of the 5-HTTLPR on amygdala volume in patients with bipolar disorder and healthy individuals and secondly to test a diagnosis specific influence of the 5-HTTLPR on amygdala volume. We performed a region of interest analysis of amygdala volume in 37 patients with bipolar I disorder and 37 healthy control subjects. The 5-HTTLPR genotype of each proband was determined and the subjects were separated according to 5-HTTLPR genotype and for statistical analyses the groups SS and SL were combined and compared with the group LL. This study shows that carriers of the short allele (SL or SS) of the 5-HTTLPR polymorphism exhibit a relatively increased volume of the right amygdala compared to homozygous L-allele carriers irrespective of diagnosis status. However, further analyses with the factors genotype and diagnosis were not able to reproduce this result. The present findings are consistent with the view that the 5-HTTLPR polymorphism might modulate neuronal size or number in the amygdala. It would be worthwhile investigating the relationship between serotonin transporter function and amygdala function and volume in further studies
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