635 research outputs found
Beyond Lesson Studies and Design Experiments: Using theoretical tools in practice and finding out how they work
No full textThis paper aims to illustrate how fruitful insights into the link between school teaching practice and student learning outcomes can be theoretically grounded by the variation theory from the field of phenomenography; and from this framework demonstrate how a 'pedagogy of awareness' can be implemented in the classroom. In this study, five teachers and 162 students at Primary Four level of school education in Hong Kong participated and the practice of the 'learning study' was adopted. By comparing the results of pre- and posttests, a significant gain was observed in the students learning outcomes.
Palps across the tree - the neuronal innervation and development of sensory head appendages in Annelida
No full textPolychaetes inhabit a wide variety of habitats and show a great morphological diversity. In this context, a key morphological structure for adapting to their individual lifestyles and ecological niches are the prominent head appendages. In the last years more and more studies focused on the mainly sensory annelid head appendages - namely the antennae, palps, buccal lips and cirri - to unravel the evolutionary origin and phylogeny of Annelida. Unfortunately, comparable data for most of the polychaete families are lacking so far, especially when it comes to features of the larval anterior nervous system and the related innervation and potential homology of these head appendages. In this study, we therefore use an integrative morphological approach including immunohistochemistry and confocal laser scanning microscopy in combination with histological serial sections and 3D-visualizations. With special focus on the palp-like appendages, our data provides a closer look into the development of the larval anterior nervous system and the related sensory structures of three polychaete families representing major groups of the annelid tree of life. Hence, we investigate members of the palaeoannelid Magelonidae as well as basally-branching Amphinomidae, and the pleistoannelid Spionidae forming a taxon deeply nested within Sedentaria. Our comparative data of larval and adult neuronal features support the homology of feeding-palps across the annelid tree. Furthermore, our observations show that larval palps gradually transform into the adult ones while keeping a very similar neuronal innervation pattern. Solely for Amphinomidae a loss of larval palps during ontogenesis has to be assumed. Therefore, our investigations uncover important and so far unknown details in terms of structural homology across Annelida and provide important results necessary for our understanding of annelid evolution.Open-Access-Publikationsfonds 202
Empirical analysis of the Linder hypothesis : the case of Japan
No full textThe aim of this work is to test empirically the validity of the Linder Trade Hypothesis for the case of Japan in the period 1980-2007. While the theoretical part presents summary of Linder Trade Theory as well as an overview of empirical studies dealing with Linder Hypothesis, for the purpose of the empirical part a gravity type model for panel data was constructed. For estimation in GRETL software the fixed effect method with HAC robust standard errors covariance matrix was used. As the main innovation in the testing approach the author considers two facts. Firstly it is the very nature of Japan itself that, as an island country separated geographically from its trading partners, offers an ideal object to test the Linder Hypothesis, because the main weakness of the precedent tests has been the inability to deal with geographical clustering. And secondly it is the method of testing that uses panel data, which helps to account for individual features of partner countries. The study does not come with any definite results as it tackles low statistical significance of estimates, but it provides reader with thorough theoretical summary of the problem
Empirical analysis of the Linder hypothesis : the case of Japan
No full textThe aim of this work is to test empirically the validity of the Linder Trade Hypothesis for the case of Japan in the period 1980-2007. While the theoretical part presents summary of Linder Trade Theory as well as an overview of empirical studies dealing with Linder Hypothesis, for the purpose of the empirical part a gravity type model for panel data was constructed. For estimation in GRETL software the fixed effect method with HAC robust standard errors covariance matrix was used. As the main innovation in the testing approach the author considers two facts. Firstly it is the very nature of Japan itself that, as an island country separated geographically from its trading partners, offers an ideal object to test the Linder Hypothesis, because the main weakness of the precedent tests has been the inability to deal with geographical clustering. And secondly it is the method of testing that uses panel data, which helps to account for individual features of partner countries. The study does not come with any definite results as it tackles low statistical significance of estimates, but it provides reader with thorough theoretical summary of the problem
The Creation and Evolution of Clina, a Journal of Translation, Interpreting and Intercultural Communication (2013-2017)
No full textThe origins, development and editorial management of Clina, an academic journal dedicated to translation, interpreting, and intercultural communication, published by the University of Salamanca are the focus of this article. Founded in 2013 by faculty members from the university’s Department of Translation and Interpreting, Clina launched its first issue in 2015, originally publishing non-thematic issues. Starting with the current issue, the journal adopts a solely monographic format, with each issue curated by guest editors focusing on specific, current topics in Translation and Interpreting Studies (TIS). The collaborative model behind the journal's editorial management, which uses a rotating co-editorship to balance continuity with innovation, serves as a framework for pairing experienced editors with less experienced colleagues. In this article, we highlight the journal’s open-access digital format and its growing professionalization, including DOI implementation and on-demand print options. The special issue, “Translation and Interpreting: Methodological and Professional Issues,” marks a transition away from open submissions toward fully themed monographic issues guest-edited by experts in the topic of each issue. The current issue includes articles on translation methodology, interpreter training through blended learning, and case studies addressing professional challenges such as code-switching in literature, subaltern voices in translation history, queer representation in translated texts, and role conflicts among social interpreters and intercultural mediators in healthcare. Through this reflective overview, the author underscores Clina's commitment to advancing under-researched topics, fostering international scholarly collaboration, and bridging academic and professional perspectives in the translation and interpreting fields
UEG882520 Supplemental Material - Supplemental material for Mean muscle attenuation correlates with severe acute pancreatitis unlike visceral adipose tissue and subcutaneous adipose tissue
No full textSupplemental material, UEG882520 Supplemental Material for Mean muscle attenuation correlates with severe acute pancreatitis unlike visceral adipose tissue and subcutaneous adipose tissue by Hanna Sternby, Mariella Mahle, Nicolas Linder, Laureen Erichson-Kirst, Robert C Verdonk, Alexandra Dimova, Povilas Ignatavicius, Lucas Ilzarbe, Peeter Koiva, Anne Penttilä, Sara Regnér, Thomas L Bollen, Richard Brill, Franz Stangl, Walter A Wohlgemuth, Vijay Singh, Harald Busse, Patrick Michl, Sebastian Beer and Jonas Rosendahl in United European Gastroenterology Journal</p
Using Genomic Inbreeding Coefficient Estimates for Homozygosity Mapping of Rare Recessive Traits: Application to Taybi-Linder Syndrome
No full textThe use of inbred patients whose exact genealogy may not be available is of primary interest in mapping genes involved in rare recessive diseases. We show here that this can be achieved by estimating inbreeding coefficients from the patients’ genomic information and using these estimates to perform homozygosity mapping. We show the interest of the approach by mapping a gene for Taybi-Linder syndrome to chromosome 2q, with the use of a key patient with no genealogical information
Exploration of minor splicing function during embryonic development with the Taybi-Linder Syndrome (TALS) model
No full textLe Syndrome de Taybi-Linder (TALS) est une maladie génétique rare affectant le développement embryonnaire, caractérisée par un nanisme microcéphalique sévère et un décès précoce des patients. Le gène muté dans ce syndrome est RNU4ATAC, qui encode un petit ARN nucléaire (snRNA) non-codant : U4atac. Ce snRNA est l’une des briques composant le spliceosome mineur, une machinerie nucléaire dédiée à l’épissage des introns U12, un groupe d’introns peu étudié car présent dans ~1 % des gènes seulement. Dans le TALS, ces introns sont fréquemment retenus dans les transcrits matures, l’épissage correct des introns U12 semble donc capital pour le développement embryonnaire. L’étude du profil transcriptomique des patients TALS permet ainsi d’établir les conséquences moléculaires d’un dysfonctionnement du spliceosome mineur, nous permettant d’en apprendre davantage sur les mécanismes d’épissage des introns U12 en condition physiologique ou pathologique, et sur le rôle de l’épissage mineur dans le développement embryonnaire. Cette thèse présente la première analyse approfondie du transcriptome de cellules provenant de patients TALS. Pour mener cette analyse, nous avons développé un pipeline bioinformatique qui, à partir de données RNA-seq de seconde génération, utilise différentes méthodes dédiées à l’étude différentielle de l’expression des gènes ou de la qualité d’épissage entre patients et contrôles. L’épissage étant particulièrement complexe à analyser à partir de reads courts, deux approches complémentaires ont été utilisées : l’une classique, basée sur l’alignement des reads, et l’autre plus originale, basée sur l’assemblage des reads et permettant de détecter plus d’événements d’épissage non-annotés (KisSplice). Une des conséquences attendue d’un dysfonctionnement du spliceosome mineur est une rétention massive des introns U12 dans les ARN matures. Cependant, la détection et la quantification de rétentions d’intron chez les mammifères constituent encore aujourd’hui un challenge bioinformatique. Nous avons donc utilisé une méthode récente dédiée à l’analyse des rétentions d’introns pour caractériser le plus précisément possible le profil transcriptomique des patients TALS. J’ai ainsi participé au développement de KisSplice et de notre outil d’analyse statistique des différentielles d’épissage, kissDE, et mis en évidence certaines caractéristiques de l’épissage mineur, que ce soit en condition physiologique ou pathologiqueThe Taybi-Linder Syndrome (TALS) is a rare genetic disorder of the embryonic development leading to a severe microcephaly, a primordial dwarfism and an early/unexpected death. The mutated gene in this syndrome is RNU4ATAC, which encode a non-coding small nuclear RNA (snRNA) named U4atac, involved in the minor spliceosome. This nuclear machinery is dedicated to the splicing of a small number of particular introns : the U12 introns. Because only about 1 % of the Human’s genes display at least one U12 intron, they have not been extensively study and little is known about their function. In TALS patients’ cells, most of the U12 introns are retained in mature transcripts ; hence, splicing of U12 introns seems important for the embryonic development. Studying TALS patients’ cells transcriptomes both in physiological and pathological conditions should enable us to precisely identify most of the molecular consequences of a minor splicing defect and could shed light on the mechanism linking minor splicing and embryonic development. This thesis is the first work to conduct an in depth analysis of TALS patients’ cells transcriptomes. In order to do a precise analysis, we developed a bioinformatic pipeline that uses multiple methods to detect differentially expressed or spliced genes between patients and controls and from second generation RNA-seq data. Splicing analysis is a very complex task complete with short reads ; hence, we used two complementary approaches. The first one is based on reads alignement to a reference genome, method conventionnally used to work on splicing, and the second one is based on reads assembly (KisSplice), a original method enabling to find more non-annotated splicing events. One of the expected consequences of a minor splicing malfunction is a global U12 introns retention in mature transcripts. However, intron retention detection and quantification in mammals is particulary difficult task in mammals, thus we used a new method dedicated to intron retentions analysis to study the transcriptomic profile of TALS patients. During my thesis, I was one of the developer of KisSplice and kissDE, our differential splicing analysis tool, and I identified important charcteristics of minor splicing either in physiological or pathological condition
Grundskolans årskursindelning : En studie av kommunpolitikers argument vid grundskolans årskursindelning
No full textAbstract Title: Grades at Primary School – A study of local politicians' arguments in connection with the division into grades at Swedish primary schools. Author: Annie Linder University of Kalmar C-essay in Social Studies Autumn 2011 The study aims to investigate local politicians' decisions since municipalities took over Swedish primary education in 1990/91. The arguments put forward in support of how stages are organised have been studied, likewise whether municipalities have acted rationally when making their decisions. Six municipalities are included in the survey. They were divided into three educational categories: lower, middle and high level schools; previous and recent schools and F9 schools with pre-schools and primary schools integrated. Minutes from politicians' and civil servants' meetings have been studied and categorised according to arguments for and against. The most common supportive arguments are about economy and organisation, others concern school premises, trends and the wish for a comprehensive compulsory school. The arguments against are few. Those most often put forward are about about the difficulties of organising B-language tuition for grade six pupils. The Rational Actor Model has been used to study whether municipalities have acted rationally when making their decisions. A third of the six municipalities have acted rationally. Key words: municipality, primary school, grade, stage, rationality
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