291 research outputs found
Ben tu man hua ji xin Xianggang ben tu shen fen de xing cheng: yi Gang man "Gu huo zi" wei li
No full textPun, Lok-fai.Thesis M.Phil. Chinese University of Hong Kong 2015.Includes bibliographical references (leaves 85-98).Abstracts also in Chinese; appendix in Chinese.Title from PDF title page (viewed on 14, November, 2016).Pun, Lok-fai
Synthetic Polymers To Address Multiscale Drug Delivery Challenges For Cancer Immunotherapy
No full textThesis (Ph.D.)--University of Washington, 2025Immunotherapy has revolutionized cancer treatment, yet its clinical impact is limited by toxicity and/or low therapeutic response in many different tumor types. Eliciting optimal spatiotemporal antitumor immune responses is crucial to overcoming this hurdle, but is complicated by multiscale drug delivery challenges to immune activators. This work utilizes targeted, bioresponsive synthetic polymeric drug delivery platforms to address these challenges in engineering next-generation cancer immunotherapies. First, we adapted the Virus-Inspired Polymer for Endosomal Release (VIPER) platform to cytosolically deliver peptide antigens to lymphatic dendritic cells (DCs) for cancer vaccination. Co-polymerized mannose ligands confer lymph node targeting and DC internalization, while the VIPER design selectively lyses maturing endosome to release peptide antigens into the cytosol. This induces superior cytotoxic T-cell activation and tumor suppression compared to simple peptide vaccines and non-endosome releasing designs. Next, we engineered a targeted polymeric prodrug of Stimulator of Interferon Genes (STING) agonist for targeted immune activation in DCs in an intravenous immunotherapy application. A STING agonist is formulated into a monomer with an endosomal cathepsin-labile linker, and co-polymerized with mannose to form a STING ‘drugamer’ (polySTING) that selectively delivers agonist to DCs. Intravenous polySTING administration results in a DC-driven immune cascade that potently suppresses tumor growth in aggressive murine tumor models. Structural variants of STING drugamers were then co-formulated with VIPER to yield two distinct STING-adjuvanted polymeric vaccines that achieved partial remission through distinct antitumor immunity mechanisms. Finally, a T-cell-targeted cationic brush polymer platform is being developed for T-cell transfection for Chimeric Antigen Receptor (CAR) T-cell production
Investigating Subtitling Strategies for the Translation of Wordplay in Wallace and Gromit - An Audience Reception Study
No full textThis thesis constitutes an experimental, receptor-oriented study which investigates the reception of two different strategies for subtitling English wordplay into German. Two translations of the animated short film Wallace and Gromit in A Matter of Loaf and Death are screened for test audiences, whose reaction is then recorded in a questionnaire. The existing translation, which was broadcast on German television and published on DVD, follows an approach based on formal equivalence and therefore rarely diverges from the original dialogue at word level, but equally sacrifices parts of the extensive humorous content inherent the text. This is contrasted by a specifically produced alternative translation which prioritises equivalence of effect, the transfer of linguistic humour at the cost of formal similarity. The research project also explores the influence of source language comprehension on the reception of both versions, as it is assumed that a formally different subtitle text could be interpreted as "incorrect" by members of the audience with knowledge of English. In light of the fact that English as a second language is spoken by a growing number of people in the German language community, the effect of this development on the viewers' requirements for audiovisual translation strategies and modes of linguistic transfer are considered relevant for the field. Furthermore, the reception of subtitling by a German audience is investigated in this context
Reloadable multidrug capturing delivery system for targeted ischemic disease treatment
No full textHuman clinical trials of protein therapy for ischemic diseases have shown disappointing outcomes so far, mainly because of the poor circulatory half-life of growth factors in circulation and their low uptake and retention by the targeted injury site. The attachment of polyethylene glycol (PEG) extends the circulatory half-lives of protein drugs but reduces their extravasation and retention at the target site. To address this issue, we have developed a drug capture system using a mixture of hyaluronic acid (HA) hydrogel and anti-PEG immunoglobulin M antibodies, which, when injected at a target body site, can capture and retain a variety of systemically injected PEGylated therapeutics at that site. Furthermore, repeated systemic injections permit "reloading" of the capture depot, allowing the use of complex multistage therapies. This study demonstrates this capture system in both murine and porcine models of critical limb ischemia. The results show that the reloadable HA/anti-PEG system has the potential to be clinically applied to patients with ischemic diseases, who require sequential administration of protein drugs for optimal outcomes
iPod... iCon
No full textThe iPod became, for a moment at least, iconic amongst those hand-held electronic devices with buttons and screens, noises and "connectivity" that proliferated at the beginning of the twenty-first century. This essay explores how the iPod, in becoming an unobtrusive memory machine as absent as an internal organ on the body of its user, provides a personal and separate experience that appears to express individual identity. But the organic form of the object as a personal store of culture obscures its role as a brand that ties its user into networks of connectivity. The iPod operates as a node in a network that co-opts the user into the circuits of a soft capitalism through an instrumental rationality that organises musical and other memories according to a modern bureaucratic computerised system
The Winter Fishery in Western Lake Erie, with a Census of the 1942 Catch
No full textAuthor Institution: Franz Theodore Stone Laboratory, The Ohio State University, Pun-in-Bay, Ohi
A.J. Potter (1918-1980): The career and creative achievement of an Irish composer in social and cultural context
No full textA. J. Potter (1918-1980) was one of the most significant composers working in Ireland in the latter part of the twentieth century. This thesis surveys his career and creative achievement, which have not hitherto been subjected to detailed scrutiny. The opening chapter presents a biographical overview: its first part outlines the circumstances of Potter's childhood and early adulthood, including his studies with Vaughan Williams at the Royal College of Music in London, his period of service in the British Army during World War II and his subsequent three-year sojourn in Africa; the second continues the narrative from 1951, when he settled permanently in Ireland, up to his death in 1980. In addition to detailing events of note in his private and professional life, an important subsidiary focus of this section is to depict the impoverished and culturally marginalised nature of Irish musical life at this period and describe the frustrations that these conditions engendered for the composer and his contemporaries. The remaining chapters are devoted to an examination of Potter's major works. Chapter 2 considers four student compositions that were written or conceived in the late 1930s and were subsequently revised when he resumed composing in 1949 after a creative silence of over a decade. Chapter 3 is divided in two parts: the first delineates the salient features of his mature creative aesthetic, while the second provides an account of his later orchestral works. The remaining chapters explore his choral music and stage works, which, in addition to the scores previously described, constitute his most noteworthy achievements
Superbroadband near-infrared emission and energy transfer in Pr³⁺-Er³⁺ codoped fluorotellurite glasses
No full textAuthor name used in this publication: Yuen H. Tsang2011-2012 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishedVoR allowe
Superbroadband near-IR photoluminescence from Pr³⁺-doped fluorotellurite glasses
No full textAuthor name used in this publication: Yuen H. Tsang2011-2012 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishedVoR allowe
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