1,720,982 research outputs found

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Author Index

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    koamabayili/VECTRON-author-checklist: VECTRON author checklist

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    We have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used

    Author Under Sail The Imagination of Jack London, 1893-1902

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    In Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries

    Life of Tau: Oligomerization, CNS Extracellular Clearance and Role as Plasma Biomarker

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    The microtubule associated protein tau (MAPT, commonly referred to as tau) is an intrinsically disordered, highly soluble protein predominantly expressed in axons where it binds and stabilizes microtubules. Under normal physiological conditions, soluble monomeric tau is released in the extracellular space in the interstitial fluid (ISF) by neurons. Additionally it undergoes reversible phosphorylation and other extensive modifications inside the cell under the action of a host of enzymes. However in the disease process tau loses this solubility, detaches from microtubules and ultimately migrates to the somatodendritic compartment of the neuron, where it ultimately forms insoluble fibrillar aggregates known as tau tangles. The nature, timeframe, and inciting factors of this transformation are active areas of research and as such, remain only partially understood. In addition to its role in AD, tau is also implicated in several other neurodegenerative conditions collectively referred to as tauopathies, all of which feature insoluble tau tangles. This list, which is still evolving, includes conditions such as frontotemporal dementia (FTD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), chronic traumatic encephalopathy (CTE), and argyrophilic grain disease (AGD). The prevailing hypothesis about the pathogenesis of tauopathies is that following an initiating event, intracellular tau aggregates and eventually spreads to other parts of the brain where it seeds previously normal tau, in a prion-like manner. These seeding and spreading phenomena have been observed in numerous mouse models. The nature of tau species involved in this spread, as well as the exact mechanism of trans-synaptic spread are not well understood. Tauճ involvement in neurodegeneration has made it an attractive therapeutic target. Passive immunotherapy with monoclonal antibodies has shown promise and is being tested in clinical trials in humans. Vaccination trials are also underway. In addition, other approaches such as antisense oligonucleotides (ASOs) and small molecule inhibitors have been tested in animal models. Here we have mainly focused on three distinct but related aspects in the Ҭife of tau:Ӽ/p\u3e1. Developing methods to measure tau oligomers2. Determining clearance kinetics of extracellular tau from the CNS to the periphery3. Evaluating plasma tau as a potential biomarker for CNS tau pathologyTau oligomers are thought to be an important intermediate step en route to the eventual fibrillization of soluble monomeric tau. We developed a high-sensitivity assay on a single molecule detection platform to detect tau oligomers. Our work characterizing extracellular tau clearance is the first comprehensive work of its type and strongly suggests that dural lymphatic system plays a key role in this process. Mice lacking these lymph vessels retain more tau in the brain as well as show slowed clearance. Lastly we asked whether plasma tau could serve as a reliable biomarker for soluble CNS tau and give us an accurate snapshot of tau pathology. Administration of an anti-tau antibody resulted in dose dependent increase in plasma tau in both humans and mice, most likely because of its role in extending the half-life of plasma tau from 8 minutes to 3 hours. Furthermore plasma tau levels correlated with soluble CNS tau levels (and therefore, inversely with tau pathology), making this a potentially good strategy to monitor tau pathology load in mouse model of tauopathy and potentially in humans. The work done here represents an important step in characterizing the role of tau in normal physiology and disease and will help guide future therapy as well as diagnostic approaches
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