1,720,973 research outputs found
Methylation of Host Genes Associated with Coronavirus Infection from Birth to 26 Years
No full textDNA methylation (DNAm) patterns over time at 1146 CpGs on coronavirus-related genes were assessed to understand whether the varying differences in susceptibility, symptoms, and the outcomes of the SARS-CoV-2 infection in children and young adults could be explained through epigenetic alterations in a host cell’s transcriptional apparatus to coronaviruses. DNAm data from the Isle of Wight birth cohort (IOWBC) at birth, 10, 18, and 26 years of age were included. Linear mixed models with repeated measurements stratified by sex were used to examine temporal patterns, and cluster analysis was performed to identify CpGs following similar patterns. CpGs on autosomes and sex chromosomes were analyzed separately. The association of identified CpGs and expression of their genes were evaluated. Pathway enrichment analyses of the genes was conducted at FDR = 0.05. DNAm at 635 of the 1146 CpGs on autosomes showed statistically significant time effects (FDR = 0.05). The 635 CpGs were classified into five clusters with each representing a unique temporal pattern of DNAm. Of the 29 CpGs on sex chromosomes, DNAm at seven CpGs in males and eight CpGs in females showed time effects (FDR = 0.05). Sex-specific and non-specific associations of DNAm with gene expression were found at 24 and 93 CpGs, respectively. Genes which mapped the 643 CpGs represent 460 biological processes. We suggest that the observed variability in DNAm with advancing age may partially explain differing susceptibility, disease severity, and mortality of coronavirus infections among different age groups.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
FLOURINE FREE, BIO-BASED ANTISMUDGE POLYURETHANE COATING WITH ENHANCED FLAME-RETARDANCY
Full text linkAntismudge coating materials are generally synthesized using petroleum-based polyols and fluorinated compounds, which are harmful to the environment and human health. Thus, researchers are more inclined to develop polyurethane (PU) coating from bio-based polyols and fluorine-free materials. Here, silicone-containing diol was used with soybean oil polyol (SOP) to produce PU coating. The chemical inertness to acid, base, and salt, along with the non-stick properties of silicone, would help achieve the desired properties of the anti-smudge PU coating. Metal (stainless steel) and wood coupons (oak wood) were coated with this synthesized coating material and tested to study chemical resistance along with an ink test. In addition, the coated metal coupons were subjected to water and solvent drops more than 50 times without any discernible influence on the metal. Contracted ink was used to write 1000 times on the coating and ink was easily erased by a paper napkin. The coating material was also subjected to a burning test, and the ignition time increased in direct correlation with the proportion of Si-containing diol. More than twice as long as the control sample, 11 seconds were required for Si-40 wt.% to start burning. The weight loss achieved with Si-40wt.% PU coating material is only 1%. Furthermore, after being immersed in water for 24 hours, these PU coating materials failed to demonstrate any discernible impact. With a water contact angle of 95o, this PU coating material is hydrophobic. The coatings were exhibited to test their ability to absorb solvents, as well as heat analysis. All available results suggest that environmentally friendly materials are promising candidates for future surface protective coatings
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Ayurveda management of Juvenile Idiopathic Arthritis - A Case Study
Full text linkJuvenile idiopathic arthritis is commonest inflammatory joint disease in children and adolescents. A 9‑year‑old male child of juvenile idiopathic arthritis was brought the OPD of Kaumarbhritya department with complaints of pain in multiple joints especially in lower limbs, morning stiffness, difficulty in climbing up stairs and back pain with diagnosed case of juvenile idiopathic arthritis in the last 2 months. Morning stiffness was present. Swelling observed on both knee and ankle joints. ANA and Anti CCP were positive. This treatment protocol is based on the Agnideepana, Pachana, Mridu Shodhana and Rasayan Chikitsa. Joint pain, swelling and stiffness were completely cured; ANA and Anti CCP were negative after treatment. This single case report demonstrates that juvenile idiopathic arthritis can be successfully managed through rejuvenating Ayurveda treatment
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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