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Theranostics of Glioblastoma Multiforme: In Vitro Characterization of Targeted Nanoemulsions and Creation of a 3D Statistical Heatmap to Visualize Nanoemulsion Uptake
No full textGlioblastoma Multiforme (GBM) continues to be a leading form of malignant brain cancer. GBM presents a high variability patient to patient. This provides a need for a theranostic system capable of both delivering therapeutic and in real-time visually observe results. Current methods involve months between treatment application and available results. Based on Nemucore Medical Innovation’s drug delivery vehicles, nanoemulsions (NE) containing chemotherapeutics are being utilized to target cancer cells and reduce systemic toxicity. Through the automation of required statistical analysis and creation of a wire-frame rat brain model with 174 defined brain regions a software capable of providing ‘real-time’ pharmacodynamics analysis of Gd3+ annotated, receptor-targeted NE is one step closer
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Theranostics of the Brain
No full textGlioblastoma is a heterogeneous disease such that the receptors expressed vary based on tumor location. Working with Nemucore Medical Innovations, Inc., theranostic nanoemulsions were designed and manufactured to combat Glioblastoma and other brain diseases. Engineered targeting ligands incorporated in the nanoemulsions assisted in delivery to specific regions. Magnetic Resonance Imaging determined the bio-distribution in healthy rats across the Blood-Brain Barrier. Statistical analysis was completed with T1 MRI data for 174 defined regions. A 3-dimensional heat map program was created to integrate MRI imaging and statistical analysis. In conclusion, data demonstrates targeting ligands on the nanoemulsions alter pharmacodynamics in rat brains, shown by a fully integrated imaging system
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Question Answering System for Yioop
Get PDFYioop is an open source search engine developed and managed by Dr. Christopher Pollett. Currently, Yioop returns the search results of the query in the form of list of URLs, just like other search engines (Google, Bing, DuckDuckGo, etc.) This paper created a new module for Yioop. This new module, known as the Question-Answering (QA) System, takes the search queries in the form of natural language questions and returns results in the form of a short answer that is appropriate to the question asked. This feature is achieved by implementing various functionalities of Natural Language Processing (NLP). By using NLP, the new Question-Answering (QA) System attempts to extract the necessary information from the query provided by the user and provides an appropriate answer from the available data
Enhancing Recovery and Royalties: The Flawed Decision in French v. Occidental Permian Ltd. and How Lessors Can Overcome Lease Language Barriers to Prohibit Post-Production Deductions
Get PDFIn Enhancing Recovery and Royalties: The Flawed Decision in French v. Occidental Permian Ltd., Niravkumar Patel critiques the Texas appellate court’s interpretation of royalty clauses that allowed post-production cost deductions despite seemingly clear lease language to the contrary. Patel contends that the French decision undermines lessors’ contractual intent and disrupts long-established principles governing royalty valuation. The article analyzes the court’s reasoning within the broader context of Texas oil and gas jurisprudence, particularly its treatment of “at the well” versus “market value” royalty provisions. Patel proposes drafting strategies and lease language that lessors can use to explicitly prohibit post-production deductions and safeguard their royalty interests. Ultimately, the article calls for clearer judicial guidance or legislative action to restore fairness and predictability in royalty disputes
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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