2,318 research outputs found

    Colistin use in critically ill patients: In search of the optimal dosing

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    Risposta di Roberto Imberti , MD; Giorgio A. Iotti , MD; Maria Cusato , PharmD; Mario Regazzi , PharmD alla lettera "Colistin Use in Critically Ill Patients. In Search of the Optimal Dosing" (Gennaro De Pascale , MD; Claudio Sandroni , MD; Massimo Antonelli , MD

    Massimo Planude. Epistole a Melchisedek

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    Traduzione italiana annotata delle lettere (ep. 71 – 73, 85 – 86, 89, 94 – 95, 99 – 100, 114 – 117), databili agli anni 1293 – 1296, indirizzate da Planude a Melchisedek Acropolita, fratello di Costantino Acropolita e figlio dello storico Giorgio. Con alcune proposte di miglioramento rispetto al testo critico curato da Leone P. L. M. nel 199

    Appropriate Tigecycline Use for Extensively Drug-Resistant Infections: The Standard Dose May Not Be Enough!

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    Essendo una lettera non è previsto ci sia un abstrac

    Risk factors for KPC-producing Klebsiella pneumoniae VAP: keep an eye on previous therapies!

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    Risk factors for KPC-producing Klebsiella pneumoniae VAP: keep an eye on previous therapies

    Contributi al testo delle epistole di Massimo Planude.

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    Comments of few passages from the Letteres of the monk Maximus Planudes, with a few modifications of the text estabilished from the scholar P.L.M. Leone (Maximi monachi Planudis epistulae, Amsterdam 1991

    Mass movements inventory map of the Rubbio stream catchment (Basilicata – South Italy).

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    In the Basilicata region (South Italy) slope movements, caused by soft rocks, rapid tectonic uplift, earthquakes, and seasonally heavy precipitation, constitute one of the major geologic hazards. For this reason a detailed inventory map of mass movements has been created in a test area of south-eastern Basilicata. The map was compiled from field surveys and multitemporal air photo interpretation. For each landslide, the map depicts the state of activity and dominant type of slope movement. The integration and analysis of the data obtained by using a geographic information system has produced the mass movements inventory map at a scale of 1:25,000. Mass movements are widespread and play a key role in the landscape evolution of the study area. A total of 175 landslides were recognized, occupying a surface area of 16.2 km2, about 9% of the whole basin of interest. The spatial distribution and type of mass movements are mainly related to the lithology and structural features. Field surveys coupled with interpretation of multi-temporal aerial photos allowed us to distinguish between active (20.6%) and inactive (79.4%) landslides. Mass movements, mapped on the basis of movement type, are represented by slides, flows and complex landslides. The complex and slide type movements are very common, and represent more than 86% of the landslides mapped

    Colistin use in critically ill patients: in search of the optimal dosing.

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    the recent article in CHEST (December 2010) by Imberti et al,1 which described steady-state serum pharmacokinetics and BAL concentration of colistin after IV administration of colistin methanesulfonate (CMS) in adult patients with ventilator-associated pneumonia caused by gram-negative bacteria raises questions about whether the currently used dosages of colistin methanesulfonate are appropriate in the critically ill patient, in whom larger distribution volume and increased plasma concentrations of α1-acid glycoprotein, an acute-phase protein with polymyxin-binding capabilities,5 may result in free colistin concentrations that are lower than those expected
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