141 research outputs found
Histopathologische Veränderungen einer intrazerebralen Blutung nach operativer Ausräumung im Vergleich zur fibrinolytischen und konservativen Therapie derselben : eine tierexperimentelle Studie
No full textHistopathologische Veränderungen einer intrazerebralen Blutung nach operativer Ausräumung im Vergleich zur fibrinolytischen und konservativen Therapie derselben : eine tierexperimentelle Studie
No full textMultishuttle als Alternative in der Behälterlagertechnik
No full textS.35-37Der gemeinsam von Siemens Dematic und dem Fraunhofer-IML entwickelte "Multishuttle" ist ein modular aufgebautes Behälterlagersystem, das Lagerung und Transport in einem durchgängigen Konzept vereint. Der Author ist maßgeblich an der Entwicklung beteiligt. Er schildert den jüngsten Stand des Projektes incl. Versuchsanlage am IML Dortmund.18Nr.
Creating a Chinese “Miele”? Asymmetries in the Consumer Perception of Chinese and German Brands
No full textThis paper analyzes the country-of-origin effects of Chinese brands going international. To approach this topic, the author uses a comparative case study, in which a Chinese manufacturer of white goods, Haier, and a German manufacturer, Miele, serve as examples. Fueled by “China trash” reports in EU and US media, the image of China as country of origin still has a negative connotation. The Chinese government and Chinese companies are working to change this image, since they both regard branding as important means for corporate internationalization. This paper argues that Chinese brands could achieve a similar development as did Japanese and Korean brands in the second half of the last century.</p
Teacher expectations and ethnicity. The educational and opportunities of adolescent migrants in the Netherlands
No full textDer Autor legt dar, daß es in den Niederlanden immer noch eine indirekt von ständischen Prinzipien bestimmte Schule gibt, in der die soziale Herkunft der Schüler das Lehrerverhalten bestimmt und an den Schüler je nach Schichtzugehörigkeit unterschiedliche Anforderungen gestellt werden. Der Beitrag untersucht aber auch die Rolle des Faktors Ethnizität bei der Behandlung und Beurteilung von Schülern. Die Arbeit ist Teil einer größeren Repräsentativstudie, die an 44 niederländischen Grundschulen mit einem hohen Anteil von Migrantenschülern durchgeführt wurde. In der Untersuchung erwies sich die Schichtzugehörigkeit der Schüler als bedeutsamer als die ethnische Zugehörigkeit. Das hat auch Konsequenzen für pädagogische Maßnahmen. (DIPF/Orig.)The author posits that, in the Netherlands, there still cxists a school that is indirectly ruled by principles of social class and in which the students\u27 social background determines both teacher behavior and learning requirements. Furthermore, the role of ethnicity in the treatment and assessment of pupils is examined. The investigation is part of a more comprehensive representative study carried out in forty-four Dutch primary schools with a high percentage of migrant students. It is shown that the students\u27 social background is of far greater importance than ethnicity, a fact which is of relevance also with regard to pedagogical measures. (DIPF/Orig.
Charge transfer state characterization and voltage losses of organic solar cells
No full textA correct determination of voltage losses is crucial for the development of organic solar cells (OSCs) with improved performance. This requires an in-depth understanding of the properties of interfacial charge transfer (CT) states, which not only set the upper limit for the open-circuit voltage of a system, but also govern radiative and non-radiative recombination processes. Over the last decade, different approaches have emerged to classify voltage losses in OSCs that rely on a generic detailed balance approach or additionally include CT state parameters that are specific to OSCs. In the latter case, a correct determination of CT state properties is paramount. In this work, we summarize the different frameworks used today to calculate voltage losses and provide an in-depth discussion of the currently most important models used to characterize CT state properties from absorption and emission data of organic thin films and solar cells. We also address practical concerns during the data recording, analysis, and fitting process. Departing from the classical two-state Marcus theory approach, we discuss the importance of quantized molecular vibrations and energetic hybridization effects in organic donor-acceptor systems with the goal to providing the reader with a detailed understanding of when each model is most appropriate
Fictive Worlds and ‘Real’ Worlds: The Staging and Reception of Unreliable Narration in Hollywood Cinema
No full textIn ihrer englischsprachigen Dissertation, die als dritter Band der von Knut Hickethier und Ansgar Nünning herausgegebenen Reihe "WVT-Handbücher und Studien zur Medienkulturwissenschaft" erschienen ist, untersucht Eva Laass Inszenierung und Rezeption des \u27unzuverlässigen Erzählens\u27 am Beispiel ausgewählter populärer Hollywood-Produktionen der letzten zwei Jahrzehnte. Auf der theoretischen Grundlage der kognitiven und intermedialen Narratologie entwickelt die Autorin dazu zunächst eine Typologie, welche dann an Filmen wie u. a. Forrest Gump (1994), Fight Club (1999), The Usual Suspects (1995) und Memento (2000) Anwendung findet und überprüft wird. Im Laufe ihrer Argumentation erweist sich das konsequente Einbeziehen der Rolle des Betrachters als äußerst produktiv. Die Studie schließt mit der sozialen Dimension dieser besonderen Erzählform und ihrer Einordnung in den (hollywoodschen) soziopolitischen Kontext.Eva Laass\u27 English-language dissertation investigates the staging and reception of \u27unreliable narration\u27 in film, using examples of popular Hollywood productions from the last two decades. The study was published as the third volume in the series WVT-Handbücher und Studien zur Medienkulturwissenschaft (WVT-Handbooks and Studies in Media Culture), edited by Knut Hickethier and Ansgar Nünning. Based on theoretical concepts of cognitive and intermedial narratology, the author develops a typology to describe and categorise unreliable filmic narration, which is applied and tested in close readings of films such as Forrest Gump (1994), Fight Club (1999), The Usual Suspects (1995), and Memento (2000). Consistently considering the viewer’s role as an active participant turns out to be a productive strategy in the course of her argument. The study closes with an investigation of the social dimension of unreliable narration which locates it within the specific sociopolitical context of Hollywood cinema
The Composite of Bone Marrow Concentrate and PRP as an Alternative to Autologous Bone Grafting
No full textMutations in the Key Autophagy Tethering Factor EPG5 Link Neurodevelopmental and Neurodegenerative Disorders Including Early-Onset Parkinsonism
No full textOBJECTIVE: Autophagy is a fundamental biological pathway with vital roles in intracellular homeostasis. During autophagy, defective cargoes including mitochondria are targeted to lysosomes for clearance and recycling. Recessive truncating variants in the autophagy gene EPG5 have been associated with Vici syndrome, a severe early-onset neurodevelopmental disorder with extensive multisystem involvement. Here, we aimed to delineate the extended, age-dependent EPG5-related disease spectrum. METHODS: We investigated clinical, radiological, and molecular features from the largest cohort of EPG5-related patients identified to date, complemented by experimental investigation of cellular and animal models of EPG5 defects. RESULTS: Through worldwide collaboration, we identified 211 patients, 97 of them previously unpublished, with recessive EPG5 variants. The phenotypic spectrum ranged from antenatally lethal presentations to milder isolated neurodevelopmental disorders. A novel Epg5 knock-in mouse model of a recurrent EPG5 missense variant featured motor impairments and defective autophagy in brain areas particularly relevant for the neurological disorders in milder presentations. Novel age-dependent neurodegenerative manifestations in our cohort included adolescent-onset parkinsonism and dystonia with cognitive decline, and myoclonus. Radiological features suggested an emerging continuum with brain iron accumulation disorders. Patient fibroblasts showed defects in PINK1-Parkin-dependent mitophagic clearance and α-synuclein overexpression, indicating a cellular basis for the observed neurodegenerative phenotypes. In Caenorhabditis elegans, EPG5 knockdown caused motor impairments, defective mitophagic clearance, and changes in mitochondrial respiration comparable to observations in C. elegans knockdown of parkinsonism-related genes. INTERPRETATION: Our findings illustrate a lifetime neurological disease continuum associated with pathogenic EPG5 variants, linking neurodevelopmental and neurodegenerative disorders through the common denominator of defective autophagy. ANN NEUROL 2025;98:932-950.CC BY 4.0© 2025 The Author(s). Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.Address correspondence to Dr Jungbluth, Department of Pediatric Neurology, Neuromuscular Service, Evelina London Children’s Hospital, Guy’s & St. Thomas’ Hospital NHS Foundation Trust, London, UK; E-mail: [email protected], [email protected], [email protected] work was supported by grants from the European Union Horizon 2020 Program (765912—DRIVE—H2020-MSCA-ITN-2017) to C.D., M.F., and H.J.; Action Medical Research (2446) to H.J. and M.F.; and Action Medical Research (GN2959) to K.S. and M.R.D.. H.J., M.F. and M.G. like to thank the Rare Genomics Institute for their support, and Taconic Biosciences for the generation of the EPG5 mouse model investigated in this study. H.S.D. was supported by the Koeln Fortune Program/Faculty of Medicine, University of Cologne (371/2021 and 243/2022), as well as the Cologne Clinician Scientist Program/Medical Faculty/University of Cologne and German Research Foundation (CCSP, DFG project No. 413543196). A.A. was supported by the Max Planck Gesellschaft. T.S.B. was supported by the Netherlands Organization for Scientific Research (ZonMw Vidi, grant 09150172110002), and acknowledges ongoing support from EpilepsieNL and CURE Epilepsy. K.Õ. is supported by an Estonian Research Council grant PRG2040. Funding bodies did not have any influence onstudy design, results, and data interpretation or final manuscript. Some of the authors of this publication are members of the European Reference Network on Rare Congenital Malformations and Rare Intellectual Disability ERN-ITHACA (EU Framework Partnership Agreement ID: 3HP-HP-FPA ERN-01-2016/739516). Also supported in part by US National Institutes of Health HG011758 and NS105078 to J.R.L. N.E.M. receives National Institutes of Health (NIH) funding (1K08NS131581) and is supported by the ASAP Global Parkinson’s Genetics Program (GP2). Biospecimens used in this article were obtained from the Northwestern Movement Disorders Center (MDC) Biorepository. As such, the investigators within the MDC Biorepository contributed to the design and implementation of the MDC Biorepository, and/or provided data and collected biospecimens, but did not participate in the analysis or writing of this report (Rizwan Akhtar, MD, PhD; Tanya Simuni, MD; Puneet Opal, MD, PhD; Monika Szela MHA; Joanna Blackburn, MD; and Lisa Kinsley, MS, CGC). We thank the Coriell Institute for Medical Research (Camden, NJ, USA) and Dr Fleur Vansenne (Groningen, the Netherlands) for their kind gift of EPG5-mutated patient fibroblasts. We thank Dr Susan Byrne (Dublin, Republic of Ireland) for her past work on EPG5-related Vici syndrome. This paper is dedicated to the memory of David Chanan Harris (2006-2025) and Kennedy Rose Bowen (2019-2021). Open Access funding enabled and organized by King's College London.</p
Current Concepts: Simple and Complex Elbow Dislocations – Acute and Definitive Treatment
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