1,721,148 research outputs found
Late recurrence of infantile hypertrophic pyloric stenosis
No full textA case of infantile hypertrophic pyloric stenosis that recurred 2 months after Ramstedt's operation is presented. A second pyloromyotomy was carried out with resolution of symptoms. A computer-based review of the literature suggests that this is the first such report. © 1994 Springer-Verlag
Vagina and External Female Genitalia
No full textLABIAL SYNECHIAE - Developing because of estrogens deficiency in presence of recurrent inflammations, usually asymptomatic. No treatment is usually required, since spontaneous opening can be expected; application of an oestrogen cream can quicken this process. HYMENEAL ATRESIA - Usually unknown until puberty, when menstruations start, causes hydrometrocolpos or haematometrocolpos. Diagnosis is clinical (protrusion of the hymen outside the vulva) and US. Treatment is surgical (opening of the hymen). © 2009 Springer-Verlag
Reorientational Dynamics of Amyloid-β from NMR Spin Relaxation and Molecular Simulation
No full textAmyloid-β (Aβ) aggregation is a hallmark of Alzheimer's disease. As an intrinsically disordered protein, Aβ undergoes extensive dynamics on multiple length and time scales. Access to a comprehensive picture of the reorientational dynamics in Aβ requires therefore the combination of complementary techniques. Here, we integrate 15N spin relaxation rates at three magnetic fields with microseconds-long molecular dynamics simulation, ensemble-based hydrodynamic calculations, and previously published nanosecond fluorescence correlation spectroscopy to investigate the reorientational dynamics of Aβ1-40 (Aβ40) at single-residue resolution. The integrative analysis shows that librational and dihedral angle fluctuations occurring at fast and intermediate time scales are not sufficient to decorrelate orientational memory in Aβ40. Instead, slow segmental motions occurring at ∼5 ns are detected throughout the Aβ40 sequence and reach up to ∼10 ns for selected residues. We propose that the modulation of time scales of reorientational dynamics with respect to intra- and intermolecular diffusion plays an important role in disease-related Aβ aggregation
Mediastinal sympathetic tumours in children
No full textEleven children suffering from mediastinal tumours of sympathetic origin (4 neuroblastomas, 2 ganglioneuroblastomas, and 5 ganglioneuromas) are presented. In almost all instances the tumours were discovered by chance following radiological studies of the chest undertaken for various reasons; in 1 case the tumour was unexpectedly discovered during surgery for a retroperitoneal mass. VMA urinary levels were in all cases within the normal range. Surgery was performed as soon as possible. In 5 cases the mass was completely removed, in 5 others incompletely and in 1 case only the extrathoracic portion of the neoplasm was partially removed. In 5 of the 6 malignant cases surgery was followed by complementary radio- and chemotherapy. All the children are in good health 2 mo. to 15 yrs. from the date of surgery. The outstanding results obtained in the histologically unfavourable cases (including the 5 in which surgical removal was incomplete) are further confirmation of how the adequately treated mediastinal neuroblastoma has greater possibilities for being cured than the retroperitoneal one. Age (5 children were under two years) and possible spontaneous maturation of the neoplasm may have played an important role in the favourable outcome as well. Furthermore, in those cases in which the residual neoplasm was subjected to electrosurgical fulguration, a role in the healing process can probably be attributed to immunological factors
WHY DEMAND UNCERTAINTY CURBS INVESTMENT
No full textFrom a theoretical point of view, uncertainty over the demand for a firm’s product may
have unclear effects on investments, as it depends on a number of factors, such as the
production technology and the degree of competition in the product market. Most of the
empirical research has been based on cross-section analysis, which has prevented a
deeper investigation of the interplay of different factors in the temporal dimension. The
aim of this paper is to extend the results of the empirical literature by using a panel of
Italian firms over a fairly long period of time (1996-2004), covering a complete business
cycle. A key finding of our paper concerns the role played by the degree of the
competition faced by Italian firms over the 1996-2004 period. More specifically, the
gradual loss of market power experienced by Italian manufacturing firms along with the
increasing flexibility of the labour input may have contributed to weaken the negative
effect of uncertainty on investment decisions
Forecasting industrial production in the Euro area
No full textThe creation of the Euro area has increased the importance of obtaining timely information about short-term changes in the area's real activity. In this paper we propose a number of alternative short term forecasting models, ranging from simple ARIMA models to more complex cointegrated VAR and conditional models, to forecast the index of industrial production in the euro area. A conditional error-correction model in which the aggregate index of industrial production for the area is explained by the US industrial production index and the business confidence index from the European Commission harmonised survey on manufacturing firms achieves the best score in terms of forecasting capacity
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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