201,685 research outputs found
Erratum: Identification of the goat CSN1S1F allele by means of PCR-RFLP method (Animal Genetics (2000) 31 (342))
No full textErratum
Ramunno L., Cosenza G., Pappalardo M., Pastore N., Gallo D., Di Gregorio P. & Masina P. (2000) Identi®cation of
the goat CSN1S1F allele by means of PCR-RFLP method. Animal Genetics 31, 34
A biological optimization problem on the Grid
No full textVaccine and drug discovery is
a lengthy process. Mathematical-computational
models can speed-up the process. In cancer immunology
the Triplex vaccine [Pappalardo et
al.(2005)] prevented mammary carcinoma formation
in HER-2/Neu mouse models using a Chronic
Schedule, but it is not known if this schedule is
minimal.
The use of the SimTriplex model and Genetic
Algorithms produced a minimal vaccination
schedule capable of guarantee in silico survival
[Pappalardo et al.(2005)] requiring an HPC infrastructure
for several days.
In this paper we show a novel optimal protocol
search algorithm based on Simulated Annealing
(SA) capable to greatly reduce the computational
effort. The COMETA grid infrastructure has been
used for protocol search and validation
Free Vascularized Toe Joint Transfer to the Metacarpal phalangeal Joint: new surgical techniques to improve the functional outcome
No full textFree Vascularized Toe Joint Transfer to the Metacarpal phalangeal Joint: new surgical
techniques to improve the functional outcome.
Objectve: Reconstruction of dysfunctional or painful damaged metacarpophalangeal joints (MCPJs)
is challenging. The current treatment of choice remains controversial, including arthrodesis, implant
arthroplasty or vascularized joint transfer (VJT). Although previous studies showed that implant
arthroplasty provide superior range of motion (ROM) than VJTs, in young or high-demand patients
for whom either potential growth or maintenance of a good ROM is required, VJTs provide a good
solution to their needs. Furthermore in case of tendon and skin defects, VJTs can also provide specific
soft tissue replacement, in a one-stage procedure. Since the toe metacarpal phalangeal joint (MTPJ)
and finger MCPJ have similar anatomical structure, vascularized MTPJ transfer is an ideal transplant
for reconstructing the damaged MCPJ, except for having dorsal extension as its main function. The
aim of this study, is to provide new anatomical knowledge and reconstructive techniques in a clinical
series for the reconstruction of the MCPJ using toe joint transfers.
Methods: Nine patents (eight male and one female) with ankylosed MCPJ underwent reconstruction
with vascularized second-toe MTPJ transfer over a five-year period. All cases suffered from posttraumatic arthritis. The average age of the patients was 42.3 years. The follow-up period ranged from
8 to 37.5 months and outcomes were assessed by grip strength and ROM of the reconstructed joints.
Results: All of the joints survived without any microvascular compromise. At an average period of
4.5 weeks bony union was achieved in all patients. Constant and sizable articular branch originated
from the first plantar metatarsal artery was intentionally included to achieve reliable blood supply to
the MTPJ. Indeed, to overcome the problem of excessive dorsal extension of MTPJs in four cases we
adopted the Turnover Technique in which the joint is turned upside-down around its longitudinal axis
and in two MTPJ we used the 45o Oblique Osteotomy technique of the metatarsal head. In addition,
in two cases an innovative modification of the skin paddle design was performed. A fillet flap from
the same toe based on the distal run off of the tibial plantar digital artery provided additional skin for
coverage the neo-MCPJ. No evidence of postoperative arthritis was noted and a total ROM of 57.8o
(mean flexion, 72.2o
) was achieved over the follow-up period
Conclusion: Vascularized second-toe MTPJ allows for restoration of powerful pinch/grasp and ROM
of a MCPJ in the hand. Improvement of the surgical techniques can result in very favorable functional
outcomes enabling more patients to benefit from VJTs
Prólogo, Yasuní: en clave de derechos y como ícono de la transición, para ubicarse en la selva de proyectos
No full textEsta investigación quiere reconstruir una visión multidisciplinaria sobre el Yasuní a partir de la Iniciativa que representa una oportunidad para revelar el contexto donde se inserta la estratificación de procesos de largo plazo, gobernados por lógicas aparentemente esquizofrénicas.
Lo que se observa en el Yasuní (y alrededores) es la superposición de cinco principales políticas territoriales del Estado ecuatoriano: la producción de petróleo (varias concesiones petroleras a empresas nacionales e internacionales); la protección de la naturaleza (Parque Natural Yasuní desde 1979; y Reserva de la Biosfera Yasuní, UNESCO, desde 1989); el reconocimiento de los derechos indígenas (territorio waorani y zona intangible tagaeri taromenane); la colonización agraria (que utiliza las vías preparadas para las operaciones petroleras: por ejemplo la vía Auca); la agro-industria (la palma aceitera cerca del Lago Agrio mezclada con las actividades petroleras). El rostro polifacético del Yasuní ha sido analizado y recompuesto a partir de las miradas de diferentes disciplinas: Ciencias jurídicas, Ciencias políticas, Ciencias sociales, Economía, Ingeniería ambiental, Geografía, Cartografía, y también combinando diferentes metodologías de investigación científica y de presentación de los resultados, desde los recorridos, la navegación de los ríos y el levantamiento de datos GPS, hasta talleres con comunidades waorani; desde el ‘campo’ de los fideicomisos y de los protocolos, hasta entrevistas y evaluación de impacto
A Modified Delta-Inset Anterolateral Thigh Flap for Reconstruction of Circumferential Pharyngoesophageal Defects: Comparison Regarding Postoperative Complications Among Three Different Flap design”
No full textFree Vascularized Metatarsophalangeal Joint for Reconstruction of the Post-Traumatic Metacarpophalangeal Joint with Concomitant Soft-Tissue Defect: Strategies to Improve Outcomes
No full textGeomorphological mapping, a basic tool for interpreting rock coasts landforms: an example from Eastern Liguria (Italy)
No full textThis work deals with the geomorphological setting, with particular regard of rock coast morphologies along the coastline, of Palmaria Island, in the easternmost pan of the Ligurian coast. We carried out a detailed geomorphologic survey on the island, focused on coastal landforms. The rock seaward slope of Palmaria Island has two types of long profiles: 1) a slope over wall profile (plunging cliff) and 2) narrow rock surfaces at sea level or a few meters above it backed by steep slopes (palaeocliff). The first type of slope profile is due to the presence of faults, linked to NW-SE-striking fault system, responsible for the displacement of the eastern Ligurian continental shelf. Our data indicate the up-throw side of the fault, corresponding to the island coast, is stable, so that an incipient notch can evolve along the cliff face in connection with present day sea level. The second type of slope profile shows at its bottom a narrow, discontinuous rock platform which is currently being demanded, constrained in elevation below 5 m asl. This surface is interpreted as inherited from a past interglacial phase, thanks also to the OSL dating of a scree slope deposits that overlaps it
Modified Lymphoscintigraphy Staging as a Tool for Assessment of Lymphatic Obstruction in Lymphedema Patients and Correlation with Clinical Findings
No full textAbstract: The Submental Versus Groin Vascularized Lymph Node Transfer Flaps: A Head-to-Head Comparison of Surgical Outcomes for Breast Cancer Related Lymphedema. Plast Reconstr Surg Glob Open.
No full text- …
