238 research outputs found
Severe hypotension and fetal death due to tocolysis with nifedipine - Correspondence
No full textDimitri N. M. Papatsonis, Bruno Carbonne, Gustaaf A. Dekker, Vicki Flenady & James F. Kin
"Asset Poverty in The United States: Its Persistence in an Expansionary Economy"
No full textFrom this paper's Preface, by Dr. Dimitri B. Papadimitriou, President: Economic growth and a rising stock market in the 1990s gave the impression that everyone was accumulating wealth and asset poverty rates were declining. The impression was supported by the official, income-based poverty measure, which exhibited a sharp decline. According to Senior Scholar Edward N. Wolff and Research Scholar Asena Caner, poverty measures should include wealth as well as income. Their study of asset poverty in the United States between 1984 and 1999 focuses on the lower end of the wealth distribution and shows that asset poverty rates did not decline during the period studied, and that the severity of poverty increased. It also shows that asset poverty is much more persistent than income poverty.
Atosiban versus fenoterol as a uterine relaxant for external cephalic version: randomised controlled trial
No full textObjective, To compare the effectiveness of the oxytocin receptor antagonist atosiban with the beta mimetic fenoterol as uterine relaxants in women undergoing external cephalic version, ECV, for breech presentation. Design, Multicentre, open label, randomised controlled trial. Setting, Eight hospitals in the Netherlands, August, to May, . Participants, women with a singleton fetus in breech presentation and a gestational age of more than, weeks were randomly allocated in a, ratio to either, ., mg atosiban, n, or, μg fenoterol, n, intravenously for uterine relaxation before ECV. Main outcome measures, The primary outcome measures were a fetus in cephalic position, minutes after the procedure and cephalic presentation at delivery. Secondary outcome measures were mode of delivery, incidence of fetal and maternal complications, and drug related adverse events. All analyses were done on an intention-to-treat basis. Results, Cephalic position, minutes after ECV occurred significantly less in the atosiban group than in the fenoterol group, v, relative risk, ., confidence interval, ., to, ., . Presentation at birth was cephalic in, n, of the atosiban group and, n, of the fenoterol group, ., ., to, ., and caesarean delivery was performed in, n, of women in the atosiban group and, n, in the fenoterol group, ., ., to, ., . No significant differences were found in neonatal outcomes or drug related adverse events. Conclusions, In women undergoing ECV for breech presentation, uterine relaxation with fenoterol increases the rate of cephalic presentation, minutes after the procedure. No statistically significant difference was found for cephalic presentation at delivery.Joost Velzel, Floortje Vlemmix, Brent C Opmeer, Jan F M Molkenboer, Corine J Verhoeven, Mariëlle G van Pampus, Dimitri N M Papatsonis, Joke M J Bais, Karlijn C Vollebregt, Liesbeth van der Esch, Joris A M Van der Post, Ben Willem Mol, Marjolein Ko
Oxytocin Antagonists as Maintenance Therapy for Inhibiting Preterm Birth after Threatened Preterm Labour
No full textBackgroun
Does use of an intrauterine catheter during labor increase risk of infection?
No full textObjectiveTo determine whether the use of an intrauterine catheter during labor is related to the occurrence of infection in mother or newborn during labor and up to 3 weeks postpartum.MethodsWe performed a follow-up study of 1435 women who participated in a previously published multicentre randomized controlled trial in the Netherlands that assigned women in whom labor was induced or augmented with intravenous oxytocin to internal or external tocodynamometry. In the present post hoc analysis, we assessed the risk for infection, defined as a composite measure of any clinical sign of infection, treatment with antibiotics or sepsis during labor or in the postpartum period up to 3 weeks in mother or newborn.ResultsThere were 64 cases with indication of infection in the intrauterine catheter group (8.8%) versus 74 cases in the external monitoring group (10.4%). Relative risk: 0.91, 95% confidence interval: 0.77-1.1, and p: 0.33.ConclusionUse of an intrauterine catheter during labor does not increase the risk of infection.Karlijn Van Halem, Jannet J. H. Bakker, Corine J. Verhoeven, Dimitri N. M. Papatsonis, Elisabeth D. Van Oudgaarden, Petra Janssen, Kitty W. Bloemenkamp, Ben Willem J. Mol & Joris A. M. Van Der Pos
Fetal complications after placement of an intrauterine pressure catheter: a report of two cases and review of the literature
No full textBackground. Uterine contractions during labor can be monitored by external tocodynamometry or by the use of an intrauterine pressure catheter (IUPC). Since an IUPC measures the frequency of contractions as well as their strength and duration, it is thought to be more accurate than external tocodynamometry. However, limited evidence on this subject suggests that IUPC may not improve maternal or perinatal outcomes. Moreover, the use of IUPC may cause fetal complications. Cases. We describe the placement of an IUPC during induction of labor with oxytocin in two cases, one presenting with a singleton pregnancy and the other a twin pregnancy. After introduction of the IUPC, both cases were complicated by blood loss and signs of fetal distress on cardiotocography. An emergency cesarean section was performed in both cases. In the first case, extramembranous placement of the IUPC was observed, whereas in the second case, the IUPC had lacerated an arteriovenous anastomosis in the membranes, resulting in perinatal death. Conclusion. Placement of an intrauterine pressure catheter instead of external tocodynamometry has a small risk for serious fetal complications.Freke A. Wilmink, Femke F. Wilms, Roger Heydanus, Ben W. J. Mol, Dimitri N. M. Papatsoni
Author Correction: A shared neural basis underlying psychiatric comorbidity
No full textCorrection to: Nature Medicine. Published online 24 April 2023. In the version of this article initially published, the STRATIFY data also included cohort data from the ESTRA consortium, though this was not acknowledged in the author list and the section in Methods on the Stratify dataset. The Methods are now updated, and the author list is amended to combine the STRATIFY and ESTRA consortium names and to include the following authors: Marina Bobou, M. John Broulidakis, Betteke Maria van Noort, Zuo Zhang, Lauren Robinson, Nilakshi Vaidya, Jeanne Winterer, Yuning Zhang, Sinead King, Hervé Lemaître, Ulrike Schmidt, Julia Sinclair, Argyris Stringaris and Sylvane Desrivières. The STRATIFY and ESTRA consortia are now combined to list Marina Bobou, M. John Broulidakis, Betteke Maria van Noort, Zuo Zhang, Lauren Robinson, Nilakshi Vaidya, Jeanne Winterer, Yuning Zhang, Sinead King, Gareth J. Barker, Arun L. W. Bokde, Hervé Lemaître, Frauke Nees, Dimitri Papadopoulos Orfanos, Ulrike Schmidt, Julia Sinclair, Argyris Stringaris, Henrik Walter, Robert Whelan, Sylvane Desrivières and Gunter Schumann as members, and the IMAGEN consortium is updated to also include Sylvane Desrivières. Affiliations, author contributions and acknowledgements have been updated to reflect the new authorship, and all changes have been made in the HTML and PDF versions of the article
Immediate delivery versus expectant monitoring for hypertensive disorders of pregnancy between 34 and 37 weeks of gestation (HYPITAT-II): an open-label, randomised controlled trial
No full textBackground: There is little evidence to guide the management of women with hypertensive disorders in late preterm pregnancy. We investigated the effect of immediate delivery versus expectant monitoring on maternal and neonatal outcomes in such women. Methods We did an open-label, randomised controlled trial, in seven academic hospitals and 44 non-academic hospitals in the Netherlands. Women with non-severe hypertensive disorders of pregnancy between 34 and 37 weeks of gestation were randomly allocated to either induction of labour or caesarean section within 24 h (immediate delivery) or a strategy aimed at prolonging pregnancy until 37 weeks of gestation (expectant monitoring). The primary outcomes were a composite of adverse maternal outcomes (thromboembolic disease, pulmonary oedema, eclampsia, HELLP syndrome, placental abruption, or maternal death), and neonatal respiratory distress syndrome, both analysed by intention-to-treat. This study is registered with the Netherlands Trial Register (NTR1792). Findings Between March 1, 2009, and Feb 21, 2013, 897 women were invited to participate, of whom 703 were enrolled and randomly assigned to immediate delivery (n=352) or expectant monitoring (n=351). The composite adverse maternal outcome occurred in four (1·1%) of 352 women allocated to immediate delivery versus 11 (3·1%) of 351 women allocated to expectant monitoring (relative risk [RR] 0·36, 95% CI 0·12–1·11; p=0·069). Respiratory distress syndrome was diagnosed in 20 (5·7%) of 352 neonates in the immediate delivery group versus six (1·7%) of 351 neonates in the expectant monitoring group (RR 3·3, 95% CI 1·4–8·2; p=0·005). No maternal or perinatal deaths occurred. Interpretation For women with non-severe hypertensive disorders at 34–37 weeks of gestation, immediate delivery might reduce the already small risk of adverse maternal outcomes. However, it significantly increases the risk of neonatal respiratory distress syndrome, therefore, routine immediate delivery does not seem justified and a strategy of expectant monitoring until the clinical situation deteriorates can be considered.Kim Broekhuijsen, MDt, Gert-Jan van Baaren, MDa, Maria G van Pampus, MDc, Wessel Ganzevoort, MDa, J Marko Sikkema, MDd, Mallory D Woiski, MDe, Martijn A Oudijk, MDf, Kitty W M Bloemenkamp, MDg, Hubertina C J Scheepers, MDh, Henk A Bremer, MDi, Robbert J P Rijnders, MDj, Aren J van Loon, MDk, Denise A M Perquin, MDl, Jan M J Sporken, MDm, Dimitri N M Papatsonis, MDn, Marloes E van Huizen, MDo, Corla B Vredevoogd, MDp, Jozien T J Brons, MDq, Mesrure Kaplan, MDr, Prof Anton H van Kaam, MDb, Henk Groen, MDs, Martina M Porath, MDu, Prof Paul P van den Berg, MDt, Prof Ben W J Mol, MDv, Maureen T M Franssen, MDt, Josje Langenveld, M
Uncertainty and the price for crude oil reserves
No full textInnovations in futures, options, and derivative instruments permit active trading, speculating and hedging - linking markets for physical petroleum products with financial markets. These derivative markets continuously value petroleum delivered today and for future dates, providing a market price for inventories. Underground petroleum reserves are also an inventory defined by exploration surveys and development drilling. Thus, observable market information can be used to value these reserves. Option - valuation models can be used to price reserves using observable markets, but are dependent on unexplained convenience yields revealed by the term structure of futures prices. The authors apply a general inventory pricing model to petroleum inventories and generate an empirical model of the returns to storage for petroleum markets. They examine the determinants of the crude oil convenience yield using a stochastic control model. They specify optimal production and inventory conditions using a third-order cost function and estimate them using monthly observations. Their inventory arbitrage condition embodies the Hotelling principle and Kaldor's convenience yield, and includes a premium on the dispersion in crude oil prices. The empirical results suggest that returns to storage contain both a cost-reducing component and often sizable premiums associated with the dispersion of petroleum prices. Their findings suggest that crude oil markets differentiated by quality and location provide similar premiums. The premiums associated with the dispersion of petroleum prices may account for persistent backwardation in crude oil prices. This finding may also explain the wide discrepancies between Hotelling values and transaction prices found in previous studies.Economic Theory&Research,Environmental Economics&Policies,Markets and Market Access,Labor Policies,Payment Systems&Infrastructure,Oil Refining&Gas Industry,Environmental Economics&Policies,Access to Markets,Markets and Market Access,Economic Theory&Research
Foleykatheter versus prostaglandine E2-gel voor inleiden van aterme baring
No full textTitle in English: Foley catheter versus prostaglandin E2 gel for induction of labor at term: The PROBAAT studyDoel: Het onderzoeken van de effectiviteit en veiligheid van een transcervicale foleykatheter ten opzichte van vaginale prostaglandine E2-gel voor inleiden van de aterme baring. Opzet: Multicentrische, gerandomiseerde, open-label onderzoek in 12 Nederlandse ziekenhuizen in de periode 10 februari 2009-17 mei 2010. Methode: Aterme vrouwen gepland voor inleiding met een eenlingzwangerschap in hoofdligging, staande vliezen en een onrijpe cervix (bishopscore < 6) werden middels een online-systeem gerandomiseerd tussen rijping van de cervix met een transcervicale foleykatheter dan wel met vaginale prostaglandine E2-gel. De primaire uitkomstmaat was sectio caesarea, secundaire uitkomstmaten waren maternale en neonatale morbiditeit en tijd van begin van de inleiding tot geboorte. Resultaten: Er werden 824 vrouwen gerandomiseerd tussen foleykatheter (n = 412) en prostaglandine E2-gel (n = 412). Het percentage sectio’s was vergelijkbaar tussen de groepen (23 vs. 20%; RR: 1,13; 95%-BI: 0,87-1,47). Er werden in totaal minder kunstverlossingen vanwege foetale nood uitgevoerd in de groep met de foleykatheter (12 vs. 18%; RR: 0,68; 95-% BI: 0,49-0,95). De mediane tijd tot bevalling was langer (mediaan: 29 vs. 18 h; interkwartiele uitersten: 15-35 vs. 12-33). De maternale uitkomstmaten waren niet verschillend, behoudens minder patiënten met verdenking op maternale infectie durante partu in de groep met een foleykatheter (2 vs. 4%; RR: 0,41; 95%-BI: 0,17-0,98). Na inleiding met een foleykatheter werden significant minder neonaten opgenomen op de kinderafdeling (12 vs. 20%; RR: 0,60; 95%-BI 0,43-0,83). Conclusie: Inleiden van de baring à terme met een foleykatheter leidt niet tot minder sectio’s dan inleiden met prostaglandine E2-gel, maar wel tot minder bijwerkingen.Marta Jozwiak, Katrien Oude Rengerink, Jan Willem de Leeuw, Ben Willem J. Mol, K.W.M. (Kitty) Bloemenkamp, Marjan Benthem, Erik van Beek, Marja Dijksterhuis, Irene de Graaf, Marloes van Huizen, Martijn Oudijk, Dimitri Papatsonis, Denise Perquin, Martina Porath, Joris van der Post, Robert Rijnders, Liesbeth Scheepers, Marc Spaanderman en Mariëlle van Pampu
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