1,721,592 research outputs found
Vascular genetic factors and lipoprotein metabolism in human longevity
No full textComplex inter-relationships between age-associated illnesses such as vascular disease and Alzheimer’s disease (AD) suggest that biological and genetic pathways may be worthy of examination in centenarian populations to provide insights into human longevity. The search for factors involved in aging and longevity has progressed extensively in the recent years because of increased human life expectancy and elevation of the number of elderly people. Different genetic and non genetic factors have been examined in the quest to understand the biological basis of human longevity. Indeed, it can be hypothesised that centenarians have environmental and genetic factors that confer unexpected survival advantage. Examples of such advantage are characterized by marked delay or escape from age-related diseases, such as coronary artery disease (CAD), cerebrovascular disease (CVD), and AD, respectively, the first, the third, and the fourth largest causes of mortality, in the western populatio n. Th us one can suggest that genes and biochemical factors likely to be implicated in these disorders may have a role in human longevity. In this chapter, the authors discuss the evidence that genetic factors, lipids, and lipoproteins, likely to be linked to both vascular disease and AD, may have an additional role in determining human longevity, with special emphasis placed on the APOE and ACE1 genes.Complex inter-relationships between age-associated illnesses such as vascular disease and Alzheimer’s disease (AD) suggest that biological and genetic pathways may be worthy of examination in centenarian populations to provide insights into human longevity. The search for factors involved in aging and longevity has progressed extensively in the recent years because of increased human life expectancy and elevation of the number of elderly people. Different genetic and non genetic factors have been examined in the quest to understand the biological basis of human longevity. Indeed, it can be hypothesised that centenarians have environmental and genetic factors that confer unexpected survival advantage. Examples of such advantage are characterized by marked delay or escape from age-related diseases, such as coronary artery disease (CAD), cerebrovascular disease (CVD), and AD, respectively, the first, the third, and the fourth largest causes of mortality, in the western populatio n. Th us one can suggest that genes and biochemical factors likely to be implicated in these disorders may have a role in human longevity. In this chapter, the authors discuss the evidence that genetic factors, lipids, and lipoproteins, likely to be linked to both vascular disease and AD, may have an additional role in determining human longevity, with special emphasis placed on the APOE and ACE1 genes
Mediterranean Diet and Cognitive Decline. A Lesson from the Whole-Diet Approach: What Challenges Lie Ahead?
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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