1,721,364 research outputs found
Thrombolysis in dementia patients with acute stroke: is it justified?
No full textThe administration of thrombolytic therapy in
elderly patients with dementia and acute ischemic stroke
may be controversial, because the reported risk of rt-PA
associated intracerebral hemorrhage in these patients is
higher compared with that of patients without dementia
and because these patients are already disabled. Moreover,
there are known risk factors for hemorrhagic
transformation in patients with dementia: amyloid
angiopathy, leukoaraiosis and the presence of microbleeds.
In this review, we describe the impact of dementia
on functional outcome following thrombolytic therapy for
acute ischemic stroke and discuss some of the issues
related to the use of this therapy in this specific patient’s
population.The administration of thrombolytic therapy in elderly patients with dementia and acute ischemic stroke may be controversial, because the reported risk of rt-PA associated intracerebral hemorrhage in these patients is higher compared with that of patients without dementia and because these patients are already disabled. Moreover, there are known risk factors for hemorrhagic transformation in patients with dementia: amyloid angiopathy, leukoaraiosis and the presence of microbleeds. In this review, we describe the impact of dementia on functional outcome following thrombolytic therapy for acute ischemic stroke and discuss some of the issues related to the use of this therapy in this specific patient’s population
New Analytic Solutions for Galaxy Evolution: Gas, Stars, Metals, and Dust in Local ETGs and Their High-z Star-forming Progenitors
Full text linkWe present a set of new analytic solutions aimed at self-consistently describing the spatially averaged time evolution of the gas, stellar, metal, and dust content in an individual star-forming galaxy hosted within a dark halo of a given mass and formation redshift. Then, as an application, we show that our solutions, when coupled to specific prescriptions for parameter setting (inspired by in situ galaxy-black hole coevolution scenarios) and merger rates (based on numerical simulations), can be exploited to reproduce the main statistical relationships followed by early-type galaxies and their high-redshift star-forming progenitors. Our analytic solutions allow one to easily disentangle the diverse role of the main physical processes regulating galaxy formation, quickly explore the related parameter space, and make transparent predictions on spatially averaged quantities. As such, our analytic solutions may provide a basis for improving the (subgrid) physical recipes presently implemented in theoretical approaches and numerical simulations and can offer a benchmark for interpreting and forecasting current and future broadband observations of high-redshift star-forming galaxies
New Analytic Solutions for Galaxy Evolution. II. Wind Recycling, Galactic Fountains, and Late-type Galaxies
No full textWe generalize the analytic solutions presented in Pantoni et al. by including a simple yet effective description of
wind recycling and galactic fountains, with the aim of self-consistently investigating the spatially averaged time
evolution of the gas, stellar, metal, and dust content in disk-dominated late-type galaxies (LTGs). Our analytic
solutions, when supplemented with specific prescriptions for parameter setting and with halo accretion rates from
N-body simulations, can be exploited to reproduce the main statistical relationships followed by local LTGs; these
involve, as a function of the stellar mass, the star formation efficiency, the gas mass fraction, the gas/stellar
metallicity, the dust mass, the star formation rate, the specific angular momentum, and the overall mass/metal
budget. Our analytic solutions allow us to easily disentangle the diverse role of the main physical processes ruling
galaxy formation in LTGs; in particular, we highlight the crucial relevance of wind recycling and galactic fountains
in efficiently refurnishing the gas mass, extending the star formation timescale, and boosting the metal enrichment
in gas and stars. All in all, our analytic solutions constitute a transparent, handy, and fast tool that can provide a
basis for improving the (sub-grid) physical recipes presently implemented in more sophisticated semi-analytic
models and numerical simulations, and can serve as a benchmark for interpreting and forecasting current and future
spatially averaged observations of local and higher redshift LTGs
Dizziness and vertigo
No full textDizziness represents 10-15% of the causes of access to emergency and acceptance departments (on NEU Day 2018, the figure was 8%, with CI from 6% to 10%). The differential diagnosis of the patient with vertigo is of great importance in first aid evaluation: similar clinical presentations can be supported by very different causes (otological, neurological, or systemic) with very different prognoses, and, on the other hand, the same pathology can correspond to different syndromes
White matter lesions in the elderly: effect on brain plasticity and reserve
No full textThe effect of white matter lesions (WMLs) on the brain of elderly individuals is unclear. Most debate has focused on the clinical effect of WMLs on cognitive impairment. Large cross-sectional and longitudinal clinic- and population-based studies suggest that the effect of WMLs on global cognitive performance is relatively small, only individuals with the most severe degrees of WMLs having clinically relevant effects. Here, we review recent data suggesting that WMLs might affect brain function through impairment of brain plasticity and reserve. The clinical effect consists in inability of the brain to respond to interventions such as psychotropic drug medications or rehabilitative interventions
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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