1,720,968 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Investigation of structural dynamics and the function of membrane proteins with computational techniques
No full textWith the development of more accurate force fields and powerful computers, molecular dynamics (MD) has become a ubiquitous tool to study complex structural, thermodynamic and kinetic processes of real world systems across disciplines. MD has a long history of being employed to enhance our understanding and guide experiments by unravelling fine details at high spatial and temporal resolution. This unique feature of MD offers insights to the highly specific interactions that dictate various biological processes. This dissertation entails the use and development of advanced simulation techniques by employing synergies between statistical mechanics, computer simulations and artificial intelligence (AI) to study the complex biological processes at the interface of the biological membranes.Through the use of accelerated membrane models, which enhanced phospholipid diffusion and reorganization in the membrane using an atomistic representation, we captured repeated and spontaneous insertion of human signalling proteins, in a lipid-dependent manner. More specifically, simulations of GRP1-PH domain allowed us to capture differential binding and conformational dynamics of the PH domain in the presence of membranes containing PC,PS, and PIP3lipids in varying compositions. Interestingly, the use of Highly Mobile Membrane Mimetic (HMMM) allowed us to capture, for the first time, two distinct PIP3 binding modes,suggesting the possibility of simultaneous binding of multiple anionic lipids might dictate the recruitment and stabilization of the domain. In a separate study, membrane-binding simulations of ASAP1-PH domain shows that the overall electrostatic environment of the membrane drives the membrane recruitment of the protein and specific binding to the rare PIP2lipids, leads to its allosteric modulation. We believe that this allosteric modulation plays a very important role in the downstream signalling events.Integral membrane proteins in their native environment are also presented. As a major class of integral membrane proteins, secondary active neurotransmitter transporters strictly couple the uphill transport of the substrate, with Na+and/or H+ ions. To achieve their functional role, these transporters undergo large-scale transition between outward-facing (OF) and inward-facing (IF) states, following the so-called “alternating-access model”. To address the key role of alternating access model and elucidate the molecular mechanism of the transport cycle, we performed MD simulations combined with advanced simulation techniques on human and bacterial glutamate transporters, involved in the neurotransmission of the brain. As the human glutamate transporter is proton coupled, we first employed constant pH MD simulations to capture the proton binding site and its binding sequence. The results obtained from these simulations were further verified by our experimental collaborators. Also, we were able to uncover how the strict coupling between the substrate, Na+and H+dictates the transition cycle of the human transporter. Next, we combined the power of concerted structural biology and computational biophysics to unravel the alter-ego of a transporter.We were able to uncover, for the first time, how a transporter develops an ion channel property right in the middle of its transport cycle. Finally, the section on neurotransmitter transporters concludes with the lipid-dependent energetic characterization of conformational transitions in human glutamate transporters.
These extensive free energy calculations allowed us to capture, in atomic details, the forward transition cycle and specific intermediates which might play an important role in designing novel therapeutics against various neurological disorders. We applied our protocol to capture large-scale conformational transitions in P-glycoprotein, with the aim to uncover novel binding sites for the third-generation inhibitor. Based on this study, we were able to propose a novel inhibitory mechanism for third-generation Pgp inhibitors, where lipids are seen to enhance the inhibitory role in the catalytic cycle of membrane transporters. Lastly, in this section we employed MD simulations in combination with electrophysiology experiments to capture lipid-mediated conformational regulation of an epilepsy-causing voltage-gated potassium channel, Kv7.2.In the last section, we have developed an AI-based approach which can be combined with MD simulations to mitigate the problem of sampling. Typically, MD simulations, per construction, suffer from limited sampling and thus limited data. As such, the use of AI in molecular simulations can suffer from a dangerous situation where the AI optimization could get stuck in spurious regimes, leading to incorrect characterization of the reaction coordinate (RC) for the problem at hand. To deal with this problem of spurious AI solutions,we developed an automated approach which combines the idea from statistical physics, including the concept of maximum caliber to differentiate between the fast and the slow processes. We show the applicability of this protocol for three classic benchmark problems, namely, the conformational dynamics of a model peptide, ligand unbinding from a protein, and folding/unfolding energy landscape of a peptide.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-08-01The student, Shashank Pant, accepted the attached license on 2021-05-24 at 10:39.The student, Shashank Pant, submitted this Dissertation for approval on 2021-05-24 at 10:59.This Dissertation was approved for publication on 2021-05-25 at 09:23.DSpace SAF Submission Ingestion Package generated from Vireo submission #16656 on 2022-01-12 at 12:51:37Made available in DSpace on 2022-01-12T22:34:42Z (GMT). No. of bitstreams: 3
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koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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