197,322 research outputs found
Analisis Pengaruh Kontribusi Bank Panin Syariah terhadap Total Laba Bersih Bank Panin Konvensional
No full textThis research aims to determine The Effect of Contribution Panin Syariah Banking to Total net profit of panin Conventional banking. The sample used in this research is data Net Profit Margin, DPR, Growth Net Income and Asset Growth on Conventional panin Bank's net profit from January 2010 to December 2015. The approach used in this research is a quantitative approach with VAR (Vector Auto Regressive) analysis supported by stationary test, optimal lag test, stability test of VAR model, granger causality test, test impulse response function and variance decomposition test, assisted by Eviews software version 6.From the results of research conducted at alpha 5%, the reaserches conclude that the results of of VAR analysis that Varince Decomposition test showed that NPM variable, DPR, Income Growth, and Growth Assets to Net Income Conventional panin banking In the long term from the beginning to the end of observationiniti net profit has a more dominant influence amounted to 32.76%, by the end of the observation. Meanwhile, NPM variable has an influence on the Bank's net profit amounted to 6.01% Conventional panin Bnking , DPR variable has the effect on 9.81% and increasing of asset amounted to 21, 19%. Granger causality test results showed that all variables had a causal relationship one another, each mean every variable has a two ways relationship with other variables. While the impulse response function test results showed that the net profit Panin Conventional Banking to respon Net Profing Margin (NPM) highly balance, had positive respon, had to the increasing of negative asset, and negative respon of net profit
Supplementary Material for: Molecular Characteristics of Pancreatic Ductal Adenocarcinomas with High-Grade Pancreatic Intraepithelial Neoplasia (PanIN) Are Different from Those without High-Grade PanIN
No full textAims: We reported that pancreatic ductal
adenocarcinomas (PDACs) without high-grade pancreatic intraepithelial
neoplasia (PanIN) in the vicinity had worse prognoses than PDACs with
high-grade PanIN. However, the molecular characteristics of PDACs with
and without high-grade PanIN have not been compared. The aim of this
study is to clarify the molecular characteristics of PDACs with and
without high-grade PanIN. Method and Results: We reviewed
all of a consecutive series of 100 patients with PDACs and divided them
into 2 groups: the PDACs with PanIN-2 or PanIN-3 in the background (the
PanIN-high group, n = 60) and the PDACs without PanIN-2 or PanIN-3 in the background (the PanIN-low group, n
= 40). We evaluated the p53, p16, and SMAD4 expressions in the invasive
ductal carcinoma (IDC) components by immunohistochemical staining. KRAS
mutation was also analyzed in 80 tumors. The PanIN-low group showed
significantly more frequent “high p53 expression” and “loss of SMAD4
expression” than the PanIN-high group (p = 0.048 and p = 0.019, respectively). Loss of p16 expression was not significantly different between the groups. The rate of KRAS wild type was significantly higher in the PanIN-low group than the PanIN-high group (p = 0.024). Conclusions:
Our results demonstrated that the molecular characteristics in the
PDACs with high-grade PanIN were different from those in the PDACs
without high-grade PanIN. PDACs without high-grade PanIN may develop via
a pathway other than the PanIN-carcinoma sequence.</p
Expression of MUC16 in PanIN lesions and normal ducts.
No full text<p>(A) MUC16 expression was evaluated in tissues containing both the normal pancreas, and adjacent dysplastic lesions. While MUC16 expression was weak in the low-grade, early stage PanIN lesions (PanIN I), it progressively increases with increasing dysplasia with the highest expression observed in high-grade dysplasia (PanIN III) and PC. Note the predominant membrane staining of MUC16 in all grades of PanINs (Original magnification ×200). (B) Box plot representing the composite score of MUC16 across the different grades of PanIN lesions and normal ducts. From the box plot we observe that MUC16 is strongly expressed in PanIN II and III when compared to PanIN I.</p
Role of Galectin in the Regulation of Neural Excitability by Drosophila sialyltransferase
No full textGalectins are major sugar binding proteins that can be blocked from interactions with its sugar epitopes, galactose, by sialylation. Previous research from Panin lab has showed that sialylation affects the neural excitability. Since galectins and sialylation are so intimately linked, this study examines whether galectin has a role in neural excitability. To test the hypothesis, possible mutant fly lines with galectin gene deletion were created with hobo deletion method. Next, we will screen for the fly lines that contain galectin gene deletion. Then, we will conduct functional and behavioral analysis of the galectin mutants to investigate if neurological functions of galectin mutant flies are compromised. Finally, the galectin mutant flies will be crossed with sialyltransferase mutants to examine whether the defect is rescued or amplified. The results will shed light on the molecular and genetic mechanism of galectin in the nervous system and the mode of interaction of galectin with sialylation
The claustrum of the bottlenose dolphin Tursiops truncatus (Montagu 1821)
No full textThe mammalian claustrum is involved in processing sensory information from the environment. The claustrum is reciprocally connected to the visual cortex and these projections, at least in carnivores, display a clear retinotopic distribution. The visual cortex of dolphins occupies a position strikingly different from that of land mammals. Whether the reshaping of the functional areas of the cortex of cetaceans involves also modifications of the claustral projections remains hitherto unanswered. The present topographic and immunohistochemical study is based on the brains of eight bottlenose dolphins and a wide array of antisera against: calcium-binding proteins (CBPs) parvalbumin (PV), calretinin (CR), and calbindin (CB); somatostatin (SOM); neuropeptide Y (NPY); and the potential claustral marker Gng2. Our observations confirmed the general topography of the mammalian claustrum also in the bottlenose dolphin, although (a) the reduction of the piriform lobe modifies the ventral relationships of the claustrum with the cortex, and (b) the rotation of the telencephalon along the transverse axis, accompanied by the reduction of the antero-posterior length of the brain, apparently moves the claustrum more rostrally. We observed a strong presence of CR-immunoreactive (-ir) neurons and fibers, a diffuse but weak expression of CB-ir elements and virtually no PV immunostaining. This latter finding agrees with studies that report that PV-ir elements are rare in the visual cortex of the same species. NPY- and somatostatin-containing neurons were evident, while the potential claustral markers Gng2 was not identified in the sections, but no explanation for its absence is currently available. Although no data are available on the projections to and from the claustrum in cetaceans, our results suggest that its neurochemical organization is compatible with the presence of noteworthy cortical inputs and outputs and a persistent role in the general processing of the relative information. © 2014 Cozzi, Roncon, Granato, Giurisato, Castagna, Peruffo, Panin, Ballarin, Montelli and Pirone
PanIN neuroendocrine cells promote tumorigenesis via neuronal crosstalk
No full textNerves are a notable feature of the tumor microenvironment in some epithelial tumors, but their role in the malignant progression of pancreatic ductal adenocarcinoma (PDAC) is uncertain. Here we identify dense innervation in the microenvironment of precancerous pancreatic lesions, known as pancreatic intraepithelial neoplasms (PanIN), and describe a unique subpopulation of neuroendocrine PanIN cells that express the neuropeptide substance P (SP) receptor Neurokinin 1-R (NK1-R). Using organoid culture, we demonstrated that sensory neurons promoted the proliferation of PanIN organoids via SP-NK1-R signaling and Stat3 activation. Nerve-responsive neuroendocrine cells exerted trophic influences and potentiated global PanIN organoid growth. Sensory denervation of a genetically engineered mouse model of PDAC led to loss of Stat3 activation, a decrease in the neoplastic neuroendocrine cell population, and impaired PanIN progression to tumor. Overall, our data provide evidence that nerves of the PanIN microenvironment promote oncogenesis, likely via direct signaling to neoplastic neuroendocrine cells capable of trophic influences. These findings identify neuroepithelial crosstalk as a potential novel target in PDAC treatment
Analisis Non Performing Loan pada PT Panin Bank Tbk
No full textPenelitian ini bertujuan untuk menguji dan menganalsis tingkat Non Performing Loan (NPL) dimana membandingkan tingkat kredirt bermaslah (kredit kurang lancar,diragukan dan macet) dengan Total Kredit pada PT Panin Bank Tbk dimana semakin tinggi nilai Non Performing Loan (NPL) maka semakin buruk pengelolaan kredit begitu juga sebaliknya apabila nilai Non Performing Loan rendah pengelolaan kredit semakin baik. Populasi dalam penelitian ini adalah 37 tahun dan sampel dalam penelitian ini selama 9 tahun mulai 2010 sampai tahun 2018 dengan sampling yang digunakan adalah purposive sampling. Uji statistik mengunakan SPSS v 21 dengan teknik analsisis data menggunakan metode one sample t-test. hasil penelitian menunujukan bahwa non performig loan pada PT Panin Bank Tbk dikatakan sehat. Ini menunjukan bahwa pengelolaan dan penyaluran kredit yang diberikan oleh PT Panin Bank Tbk sudah baik dan berada dibawah ketetapan umum oleh Bank Indonesia
Three PanIN hispathological grades (HE).
No full textA:normal pancreas; B:PanIN III, minimal cytological atypia (arrow); C:PanIN III, nuclear polarity disappears, moderate cytological atypia (arrow); D: PanIN III, nuclear atypia hyperplasia, papillary or micro papillary morphology (arrow). Scale bars = 100 μm.</p
ANALISIS STRATEGI PT. ANZ PANIN BANK DALAM MENGEMBANGKAN BISNIS RETAIL BANKING DI INDONESIA
No full textThe purpose of this research is to set the strategic action for PT. ANZ
Panin Bank in developing and expanding the retail banking business. This
research will study about the backgound of PT. ANZ Panin Bank in setting up the
target for developing retail banking market, formulate the research method for the
target feasibility study to formulate the strategic action for PT. ANZ Panin Bank
in developing and expanding retail banking business and to build the best strategy
that can be implemented for PT. ANZ Panin Bank to achieve the target.
This research conducted in PT. ANZ Panin Bank which use research
methodology: field research/interview and library research. Interviewed was
conducted to 4 top management from retail banking department.
The process flow in this research consist of 3 (three) phases: a) Input
Phase, which formulate 3 (three) matrix, External Factor Evaluation (EFE), Key
success factor Internal Factor Evaluation (EFI), b) Matching Phase, following the
result from Input Phase, using SWOT, external and internal matrix dan Grand
Strategy, c) Decision Phase: using the matrix from point a & b can be formulated
the action strategy using Quantitative Strategic Planning Matrix. Following the
research for action strategy which used 3 phases of analysis above, as the result
will be market penetration strategy and market expansion strategy. PT. ANZ
Panin Bank market penetration strategy will be implemented by searching other
undeveloped potential market. The detail process which will be taken by PT.
ANZ Panin Bank are expand bank operational offices, strenghten the bank
capability, provide the customer with the best high end technology and services,
provide the best retail banking products which given more value and profitability
to customers. And for the expanding retail banking market strategy are getting the
potential customers as new customers for the bank by offering additional and
value added savings and other products, and bank should have good and stable
financial condition
PENGARUH BANK SIZE, PEMBIAYAAN MUDHARABAH, DAN PEMBIAYAAN MUSYARAKAH TERHADAP PROFITABILITAS PADA BANK PANIN DUBAI SYARIAH PERIODE 2014-2021
No full textSkripsi dengan judul “Pengaruh Bank Size, Pembiayaan Mudharabah, dan Pembiayaan Musyarakah Terhadap Profitabilitas Pada Bank Panin Dubai Syariah Periode 2014-2021” ini ditulis oleh Heldina Devitasari, NIM. 12401183037, pembimbing M. Aqim Adlan, M.E.I. Penelitian ini dilatar belakangi oleh pertumbuhan profitabilitas pada Bank Panin Dubai Syariah yang menunjukkan kecenderungan menurun selama beberapa periode, dimana penurunannya hingga menyentuh presentase negatif. Hal tersebut perlu diteliti terkait apa yang mempengaruhi profitabilitas, mengingat profitabilitas dianggap penting bagi penilaian kinerja keuangan suatu bank. Dalam penelitian ini, indikator yang diduga mempengaruhi profitabilitas pada Bank Panin Dubai adalah Bank Size, Pembiayaan Mudharabah, dan Pembiayaan Musyarakah terhadap profitabilitas yang diukur dengan Return On Asset. Rumusan masalah dalam penelitian ini adalah (1) Apakah Bank Size berpengaruh terhadap profitabilitas ROA Bank Panin Dubai Syariah tahun 2014- 2021? (2) Apakah Pembiayaan Mudharabah berpengaruh terhadap profitabilitas ROA Bank Panin Dubai Syariah tahun 2014-2021? (3) Apakah Pembiayaan Musyarakah berpengaruh terhadap profitabilitas ROA Bank Panin Dubai Syariah tahun 2014-2021? (4) Apakah Bank Size, Pembiayaan Mudharabah, dan Pembiayaan Musyarakah berpengaruh secara bersama-sama terhadap profitabilitas ROA Bank Panin Dubai Syariah tahun 2014-2021?. Penelitian ini bertujuan untuk menguji pengaruh Bank Size, Pembiayaan Mudharabah, dan Pembiayaan Musyarakah terhadap profitabilitas secara parsial maupun simultan. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian asosiatif. Teknik pengambilan sampel yang digunakan adalah sampling jenuh dengan menggunakan jenis data sekunder yaitu data laporan keuangan Triwulan Bank Panin Dubai Syariah Periode 2014-2021 yang telah dipublikasikan pada website OJK. Penelitian ini menggunakan metode analisis regresi linier berganda. Hasil penelitian yang dilakukan dan diuji menggunakan SPSS 23 menunjukkan bahwa (1) Bank size berpengaruh negatif dan signifikan terhadap profitabilitas pada Bank Panin Dubai Syariah, (2) Pembiayaan Mudharabah tidak berpengaruh terhadap profitabilitas pada Bank Panin Dubai Syariah, (3) Pembiayaan Musyarakah berpengaruh positif dan signifikan terhadap profitabilitas pada Bank Panin Dubai Syariah, (4) Secara simultan Bank Size, Pembiayaan Mudharabah, dan Pembiayaan Musyarakah berpengaruh positif dan signifikan terhadap profitabilitas pada Bank Panin Dubai Syariah periode 2014- 2021. Kata kunci : Return On Asset, Pembiayaan Mudharabah, dan Pembiayaan Musyaraka
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