1,721,058 research outputs found
Current Challenges in Immunology
No full textIn this inaugural editorial, the authors provide a brief overview of some of the current challenges in immunology. The new open access Journal ”International Trends in Immunity” (ITI) will hopefully create a forum to discuss these as well as other critical issues. Clearly there are ongoing needs for new vaccines, improved immunotherapies of cancer, novel strategies to understand and overcome immunosenescence, and address the concerns of increased incidence and severity of allergic diseases and primary immunodeficiencies. In this and future issues of the journal, we encourage provocative hypotheses based on strong experimental evidence
Apoptosis in asymptomatic HIV-1 seropositives immunized with HIV-1 env glycoprotein (gp160): effects of administration of Zidovudine in vivo and IL-2 in vitro
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Immune Modulation by Vitamin D: Special Emphasis on Its Role in Prevention and Treatment of Cancer.
No full textPURPOSE:
Vitamin D has been known to be involved in mineral and bone homeostasis for many years. In the past its main use was in treating osteoporosis and rickets. In recent years it was found that vitamin D is an immune-modulating agent and may also have a role in several diseases, including autoimmune diseases. The immune-modulating effects appear to be mediated by vitamin D interaction with the vitamin D receptor (VDR) that has transcriptional effects and is expressed on various cell types, especially those of the immune system. Immunologic and rheumatologic diseases were the first to be studied, but at the moment the spotlight is on the interactions between tumor cells and vitamin D. This review focuses on four forms of cancer that apparently benefit from a vitamin D supplementation during treatment: prostate, breast, and colorectal cancers and melanoma. Several studies reported that differences exist between white and black patients, which we discuss in the review.
METHODS:
We systematically searched PubMed for studies published in English. The search terms included vitamin D, cancer, breast, colorectal, prostate, and melanoma.
FINDINGS AND IMPLICATIONS:
Our findings show that vitamin D has the potential to become a valid coadjuvant in the treatment of cancer.
Copyright © 2017 Elsevier HS Journals, Inc. All rights reserved.
KEYWORDS:
Calcifediol (PubChem CID: 5283731); Cathelicidin (PubChem CID: 16198951); Ergocalciferol (PubChem CID: 5280793); MART10 (PubChem CID: 24779632); Quercetin (PubChem CID: 5280343); VDR; Vitamin D3 (PubChem CID: 5280795); autoimmune disorders; cancer; vitamin
Induction of "antigen silencing" in melanomas by oncostatin M: downmodulation of melanocyte antigen expression.
No full textThe Italian quality control study for evaluation of CD4 cells in centres involved in the treatment of HIV-1 patients. Italian CD4 Quality Control Group
No full textOligoclonality of Vdelta1 and Vdelta2 cells in human peripheral blood mononuclear cells: TCR selection is not altered by stimulation with gram-negative bacteria
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