113 research outputs found
A phase I and pharmacokinetic study of lapatinib in combination with letrozole in patients with advanced cancer
No full textPurpose: The main objectives of this phase I and pharmacokinetic, open-label study were to determine the optimally tolerated regimen (OTR), safety, pharmacokinetics, and clinical activity of lapatinib in combination with letrozole in patients with advanced solid malignancies. Experimental Design: Patients with advanced breast cancer with immunohistochemically detectable estrogen or progesterone receptors or other cancers were eligible. Doses of lapatinib were escalated in cohorts of three subjects from 1,250 to a maximum of 1,500 mg/d based on dose-limiting toxicities in the first treatment cycle. The letrozole dose was fixed at 2.5 mg/d. Additional patients were enrolled at the OTR dose level to further evaluate safety and for pharmacokinetic analyses. Results: Thirty-nine patients were enrolled in the study: 12 in the dose-escalation group, 7 in the OTR safety group, and 20 in the pharmacokinetic group. The OTR dose level was identified as 1,500 mg/d lapatinib and 2.5 mg/d letrozole. The most common (>25% of patients) drug-related adverse events were diarrhea (77%), rash (62%), nausea (46%), and fatigue (26%). No significant differences were observed in the pharmacokinetic variables (Cmax and AUC) of lapatinib and letrozole when coadministered compared with single-agent administration. One patient with endometrial cancer had a confirmed partial response. Conclusions: Clinically relevant doses of lapatinib in combination with letrozole were well tolerated and did not result in a pharmacokinetic interaction, and clinical antitumor activity was observed
Empowering Ni-Vanuatu women: Amplifying Wantok authority and achieving fair market access
No full textThe Republic of Vanuatu (2004) report on Vanuatu’s implementation of the United Nations Convention on the Elimination of All Forms of Discrimination against Women (CEDAW) notes that many urban disenfranchised Ni-Vanuatu women live in poverty and have little access to paid employment. The women who do gain paid employment in formal jobs rarely gain access to positions of authority. The United Nations (UN) offered two strategies to improve the position of Ni-Vanuatu women in Vanuatu. The first is informed by CEDAW in Article Eleven on Employment. The “Equity Desk of the Vanuatu Department of Strategic Management” and the “Vanuatu Department of Women’s Affairs Gender Planner” (The Republic of Vanuatu, 2004, pp. 12-13) have been charged with the responsibility of implementing Article Eleven and developing Equal Employment Opportunities (EEO) programmes for the public sector. This strategy aims to increase women’s access to paid employment in the formal employment sector and encourage women to achieve positions of authority. The second strategy offered by the UN is the establishment of microfinance projects aimed at providing disenfranchised urban women unable to find employment with a means to own and run microfinance businesses to earn a living. Both these strategies have the overarching aim of improving the well-being of Ni-Vanuatu women.
This study has investigated the extent to which access to formal sector jobs and the implementation of microfinance businesses in the informal sector addresses the well-being of Ni-Vanuatu women. These programmes are being implemented within a complex historical, socio-political cultural and economic environment (Van Trease, 1995). This complexity includes the continuance of Wantok systems of governance in the form of matrilineality (predominant in Vanuatu) and patrilineality (adopted from Christian influences in 1800s and colonial legacy in 1906) (Van Trease, 1987; Facey, 1981; Allen, 1981 & Macdonald-Milne & Thomas, 1981). Matrilineal cultural values bequeath patrimony and legacy of lineage and land inheritance from mothers to daughters. Matrilineal women share power with men in community affairs (Maltali, Sandy & Tamashiro, 2009). In patrilineal communities, patrimony and legacy of lineage and land inheritance is passed from fathers to sons (Van Trease, 1987). Patrilineal mothers and daughters have no lineage, land inheritance, or power-sharing rights (Stege, Maetala, Naupa & Simo 2008). Both Wantok systems are based on communal values practised primarily in the rural sector. Urban centres are organised around a modern-cash and market-economy and a governance framework based on the British Westminster model and the French Head of State model (ILO, 2006). This European generated governance system is underpinned by values informed by liberal competitive individualism and an assumed commitment to meritocracy. It is, however, a system of governance steeped in patriarchal nuances as a direct legacy of the colonial regime now adapted and administered by the Vanuatu’s ruling elite, referred as Vanuatu’s urban patriarchy throughout this thesis.
The theoretical frameworks used in this research draw on both liberal feminist studies and on an adaptation of subaltern scholarship (Thomas & Humphries, 2010 & 2011). The focus is on the legacy of imperialism and colonisation, the politics of power and hegemony, and the expressions of equal rights, emancipation and empowerment as these pertain to the well-being of women in Vanuatu.
Three sets of qualitative empirical observations were collected: i) a focus group discussion with 20 employer and employee representatives; ii) 36 conversations with women employed in the formal employment sector who held positions of authority within their respective organisations; and iii) 39 conversations with women who owned a microfinance business. My field notes were analysed thematically using a point and counterpoint framework crafted from my interest in the work of Huxley (cf Baker & James, 2000a & 2000b & Dawson, 2009). The point is informed by a liberal feminist lens (Gamble, 1999 & Heywood, 2000). A counterpoint to this liberal feminist interpretation is generated from a post-colonial feminist perspective through an adaptation of subaltern studies (Thomas & Humphries 2010 & 2011; Gamble, 1999 & Spivak, 1988). I draw on my Matrilineal Wantok Feminist Voice (MWFV) to form a standpoint in the discussion and to frame insights drawn from the ideas associated with the solidarity economy (Allard, Davidson & Matthaei, 2009; Harvey, 2006 & Harding, 2004).
Point/counterpoint/standpoint for the research as a whole
Point: Liberal feminist strategies for the emancipation of women (and the intended improvement and well-being of their families associated with this perspective) encourage women to pursue better living standards, achieve empowerment in the home, and seek formal jobs or other market-based income opportunities. If in formal jobs, women are encouraged to seek positions of authority. For these women, the major transition in orientation is the move from Wantok-related patterns of responsibilities and opportunities to those made available in the formal Western-generated economy. These Western ways, with emphasis on individualized opportunity, appear to offer financial gain and familial influences, particularly to women born into patrilineal lineage descent groups.
Counterpoint: Viewed through the adaptation of subaltern perspectives that I have applied to the liberal feminist remedies for the enhancement of well-being for the women of Vanuatu, it appears that the women of Vanuatu are involved in multiple and simultaneous complex master/slave relationships (Kohn, 2005 & Honderich, 1995). These relationships are exemplified in salaried/professional occupations held by women, between the women and their employers and work-place cultures, between women and rural and urban patriarchal hegemonies, and between women and the cash and market economy. While EEO activities can be seen to make a difference in the lives of some women, taken together, these interventions are reducing the overall well-being for Ni-Vanuatu women more generally. For the Vanwods microfinance women entrepreneurs, master/slave relationships could be discerned between the Vanwods MFI’s social control of the Mamas, the Vanuatu Government’s imposition of high business licence fees to the Mamas, the Mamas and their greater dependence on the cash and market economy, and the Mamas and their relationship with rural and urban patriarchal hegemonies (Thomas & Humphries, 2010 & 2011). These forms of systemic subservience interpreted from the women’s narratives provide a caution against the uncritical adoption of Western liberal feminist ideals (DeVault, 1990). It is matrilineal women; however, who appear to suffer the most from their move into the urban centres as there they must contend with an urban patriarchal hegemony, an impediment which they had not encountered in their former rural communities governed in accordance with matrilineal Wantok values.
Standpoint: The research findings suggest that all women in this study worked long hours, experiencing discrimination and oppression, received low pay, and experienced increased financial obligations as a result of their engagement in formal and informal jobs. As well as being increasingly dependent on inadequate and unsustainable livelihoods in the urban areas, family and Wantok social relations were challenged and diminished as a consequence of their necessary commitment to their jobs and the demands of urban living. Access to traditional forms of authority and sustenance was undermined.
I conclude that, overall, the implementation of CEDAW-EEO programmes along with the establishment of microfinance projects devised for the emancipation of the disenfranchised women of Vanuatu, while apparently proving beneficial from a liberal feminist interpretation in granting urban women with access to incomes, property and power-sharing, may provide an element of liberation for women of patrilineal descent groups but add new dimensions of patriarchal inhibitors for women of matrilineal descent groups who take up employment under the Westminster rules of governance. The remedies taken as a whole, while promising improved well-being through market-based income generation, remove women from the Wantok kinship social support networks embedded in their indigenous Wantok governance frameworks causing complex problems and hardships for them. Drawing on my Matrilineal Wantok Feminist standpoint position, I suggest that the Solidarity Economy, which combines aspects of market access while still engaging in the traditional systems of social organization, offers an alternative organisational and economic framework for developing and enhancing community well-being in both the rural and urban areas of Vanuatu
Survival Data From a Phase II, Open-Label Study of Pazopanib or Lapatinib Monotherapy in Patients With Advanced and Recurrent Cervical Cancer
No full text3645452
Lini Richarda Grol Fonds, 1946-2007
No full textLini Richarda Grol was originally born in Nijmegen, Netherlands in 1913 and immigrated to Canada in 1954 after working as a nurse in South America for three years from 1951 to 1954. She was granted her first Canadian passport in 1961 and worked full-time as nurse at the Welland County Hospital. While nursing she would enroll in writing courses at McMaster University and Ryerson Polytechnical Institute, now Ryerson University. Eventually she decided to dedicate herself to her writing and artwork and began to only work as a nurse part-time and then later opened the Fonthill Studio to devote herself to her writing and artwork full-time. Her status as an immigrant and career as a nurse provided inspiration for much of her writing and she frequently tackles the experience of the female immigrant in her works. Her first publication was in 1938 in a small literary and women’s magazines in Holland and Belgium and her first work of poetry was entitled Stive Gedachten. None of these publications exist in this archive. Her most well-known publication, Liberation, centers around her experiences leading up to and after the liberation of Holland during World War II.
Grol was, and continues to be a prolific writer in the Niagara Region and has been published in the Welland Tribune, Pelham Herald, Thorold News, Parent Magazine, Dunville Chronicle, and various Christian publications and literary newsletters and journals. Grol also started her own poetry magazine entitled Canadian Poets Pen Club to help aspiring writers get published. Perhaps her most recognized achievement was the inclusion of one of her poems and the recognition of her novel Liberation into the Thank You Canada Day celebration in May 1970. Grol participated in many local writers’ groups such as the Welland Writer’s Club, and the Canadian Author’s Association. Grol was membership secretary for the Canadian Author’s Association in 1984. She also founded a writer’s club in 1995 in her retirement home, Holland Christian Homes where members meet to talk about their poems and short stories either in English or Dutch. Participating in and creating a writers’ community is integral to Grol’s identity as an author and can be related to the feelings of isolation she felt as an immigrant to Canada. Grol also hosted her own television shows entitled Discovery with Lini Grol which featured guests, usually local artists and writers, and Holland en Hollanders a cultural program for Dutch immigrants.
Grol’s most recent activities include the publication of a one act play entitled Peppermint Problems [1996] and a short story entitled “When our War started in Rotterdam” [2004]. In 1994, she moved to Brampton, Ontario into a Christian retirement center called Holland Christian Homes.
For further biographical information about Grol see two books contained within this collection Women of Action [1976] and Something About the Author [1976].This fonds contains published and non-published literary works and professional correspondence, contracts, newsletters and newspaper articles retained by Grol. As well there are personal materials such as photographs, letters, contracts, and books. The fonds also contains examples of her published and original scissor cuttings
CDC Melyn yellow seed coat oilseed flax
No full textCDC Melyn is a yellow seed coat oilseed flax (Linum usitatissimum L.), registered in 2016 by the Crop Development Centre, University of Saskatchewan, Saskatoon, Saskatchewan. This cultivar has yield (106%) comparable to cultivar AC Nugget (the yield standard for yellow seed coat oilseed flax) and maturity rating equal to Flanders. It has a medium (46.6%) oil content, iodine value (199.4), alpha-linolenic acid content (61%) and a thousand seed weight of 5.0 g. It is immune to flax rust caused by Melampsora lini and moderately resistant to wilt and powdery mildew caused by Fusarium oxysporum f. sp. lini and Oidium lini, respectively.The presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
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Radiation recall dermatitis induced by methotrexate in a patient with Hodgkin's disease
No full textWCOM Initiative dengan Improvement Metode untuk Mengurangi Losses di LINI Produksi
No full textPT FF merupakan perusahaan yang memproduksi susu, dan susu kental manis menjadi produk utamanya. Saat ini, PT FF sedang menghadapi losses yang cukup tinggi di lini produksi susu kental manis line 3. Beberapa penyebab diantaranya yaitu mesin yang ada di lini tersebut adalah mesin baru yang belum lama di install, kemudian beberapa operator yang mengoperasikannya sangatlah bervariasi masa kerja dan kemampuannya.
Saat ini PT FF sudah memiliki metode untuk mengurangi losses yang terjadi yaitu WCOM Initiative. Metode tersebut memiliki beberapa tahapan yang tujuannya adalah mengurangi jumlah losses dari 0,63% dari total output menjadi dibawah 0,44% dari total output.
Setelah dilakukan metode WCOM Initiative tersebut, jumlah losses masih belum turun signifikan karena beberapa masih ada peningkatan jumlah losses. Kemudian penulis menganalisis penyebab masih tingginya losses tersebut dengan menggunakan 5 why, dan didapatilah penyebab utamanya adalah factor manusia.
Dari data tersebut kemudian ditambahkan tahapan baru yaitu close the gap (skill) dengan tujuan untuk mengurangi kesenjangan skill antara operator yang satu dengan yang lain. Hasil yang diperoleh setelah dilakukan tahapan ini adalah losses berkurang cukup signifikan dan selalu dibawah target dalam pemantauan selama tiga bulan.
Tahapan close the gap (skill) ini sebelumnya belum masuk ke dalam metode WCOM Initiative, sehingga penulis mengembangkan metode ini menjadi WCOM Initiative dengan improvement yaitu menembahkan tahap close the gap (skill) kedalamnya.
Kata kunci : world class, skill, faktor manusia, losses. / PT FF is a company that produces milk, and sweetened condensed milk is its main product. Currently, PT FF is facing high losses in the production line of sweetened condensed milk line 3. Some of the causes include the machines in this line are new machines that have not been installed for a long time, then some operators who operate them vary in terms of service and abilities.
Currently PT FF already has a method to reduce the losses that occur, namely the WCOM Initiative. The method has several stages whose aim is to reduce the number of losses from 0.63% of the total output to below 0.44% of the total output.
After using the WCOM Initiative method, the number of losses has not decreased significantly because some still have an increase in the number of losses. Then the author analyzes the causes of the high losses using 5 whys, and it is found that the main cause is the human factor.
From this data, a new stage is added, namely close the gap (skill) with the aim of reducing the skill gap between one operator and another. The results obtained after this stage are losses are significantly reduced and are always below the target in monitoring for three months.
This close the gap (skill) stage had not previously been included in the WCOM Initiative method, so the authors developed this method into WCOM Initiative with improvement by adding the close the gap (skill) stage into it.
Keyword : world class, skill, human factor, losse
Motivation of Parents to Send Their Children to Islamic Boarding Schools (Motivasi Orang Tua Menyekolahkan Anak di Pesantren)
No full textThis article is to analyze: (1) the intrinsic motivation of parents in sending their children to Islamic boarding schools; (2) extrinsic motivation of parents in sending their children to Islamic boarding schools. This research was conducted qualitatively with a narrative approach. From the results of this research, the author can draw the following conclusions: The results of the research show that the intrinsic motivation of parents to send their children to Islamic boarding schools is because: (1) the desire to make their children pious and pious; (2) discipline; (3) not only having worldly knowledge but also mastering knowledge for the hereafter and obeying religious teachings; (4) forming noble morals, (5) preventing children from negative environmental impacts. The extrinsic motivation for parents to send their children to Islamic boarding schools is because: (1) Islamic boarding schools have more religious subjects, the influence of the surrounding environment is good and there are lots of positive activities every day, (2) The method of moral development is quite good. This research suggests that education is needed for parents to become more aware of the importance of sending their children to Islamic educational institutions with a dormitory system.Keywords: Intrinsic Motivation, Extrinsic Motivation, Islamic Boarding Schoo
Feedback on the use of MATB-II task for modeling of cognitive control levels through psycho-physiological biosignals
No full textModeling individuals’ cognitive control levels in operational situations is a major challenge for safety in aeronautical industry. Standardized experimental tasks - as the Multi-Attribute Task Battery II (MATB-II) - are dedicated to such a challenge that can be faced using psycho-physiological biosignals. These biosignals are known to be sensitive to cognitive worload, performance, and expertise that are intricate features of MATB-II subtasks. Thus, it remained necessary to investigate whether these features could be set to ensure controlled experimental conditions. Two groups (15 experts in time-pressured decision making and 13 novices) completed 3 MATB-II sub-tasks (tracking, monitoring, and resource management tasks). Biosignals accounting for autonomic nervous system activity were measured continuously, as objective markers of cognition. Confrontation between performance data and (objective and subjective) cognitive markers reported contrasting perspectives regarding the exploitation of MATB-II as a pertinent tool to insure controlled experimental conditions in the context of cognitive control characterization
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