342,050 research outputs found
Role of mitochondria in neuronal cell death induced by oxidative stress: Neuroprotection by coenzyme Q(10).
No full textIn past research, oxidative stress has been implicated in aging and age related disorders. Cell death caused by oxidative stress has been shown to play an important role in neuro-degenerative diseases. We used differentiated Human Neuroblastoma (SH-SY5Y) and Teratocarcinoma (NT2N) cells as models to study the mechanism of cell death induced by oxidative stress. We observed that differentiated NT2N AND SH-SY5Y cells underwent apoptosis following oxidative stress induced by direct hydrogen peroxide treatment. Morphological, apoptotic features including nuclear condensation and membrane blebbing and biochemical changes including DNA fragmentation and caspase and proteasome activation were evident following oxidative stress. We further investigated the production of reactive oxygen species and mitochondrial dysfunction in the cell under oxidative stress. There was an increase in total ROS produced by the cells after H2O2 treatment. Furthermore, there was a decrease in the mitochondrial membrane potential and an increase in mitochondrial ROS generation. (Abstract shortened by UMI.)Dept. of Chemistry and Biochemistry. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis2004 .S66. Source: Masters Abstracts International, Volume: 43-01, page: 0216. Adviser: S. Pandey. Thesis (M.Sc.)--University of Windsor (Canada), 2004
The Influence of Environmental Conditions on Secondary Metabolites in Medicinal Plants: A Literature Review
No full textMedicinal plants, a source of different phytochemical compounds, are now subjected to a variety of environmental stresses during their growth and development. Different ecologically limiting factors including temperature, carbon dioxide, lighting, ozone, soil water, soil salinity and soil fertility has significant impact on medicinal plants′ physiological and biochemical responses, as well as the secondary metabolic process. Secondary metabolites (SMs) are useful for assessing the quality of therapeutic ingredients and nowadays, these are used as important natural derived drugs such as immune suppressant, antibiotics, anti-diabetic, and anti-cancer. Plants have the ability to synthesize a variety of secondary metabolites to cope with the negative effects of stress. Here, we focus on how individual environmental variables influence the accumulation of plant secondary metabolites. A total of 48 articles were found to be relevant to the review topic during our systematic review. The review showed the influence of different environmental variables on SMs production and accumulation is complex suggesting the relationship are not only species-specific but also related to increases and decline in SMs by up to 50 %. Therefore, this review improves our understanding of plant SMs ability to adapt to key environmental factors. This can aid in the efficient and long-term optimization of cultivation techniques under ambient environmental conditions in order to maximize the quality and quantity of SMs in plants
Gurumālā. Papers in honour of Shyam Manohar Pandey, edited by Stefania Cavaliere, Annali 68 (2008) Napoli, 2012
No full textOn 30th October 2008, the Department of Asian Studies at L‟Orientale Uni-versity of Naples organized a seminar in honour of Prof. Shyam Manohar Pandey to mark his retirement. The seminar was a tribute to his long career at the L‟Orientale University and the worldwide acclaim of his studies. Several scholars from Italian universities came to pay tribute to their esteemed colleague, as well as many students and friends who arrived to greet their much-respected teacher.
The purpose of the seminar was to bring together Italian scholars of Modern Indian Literature to discuss the state of Indological studies in Italy and to propose new lines of research in the field of popular literature in the Indian Subcontinent, which has long been Prof. Pandey‟s major field of research.
The essays in the present volume are based on the talks and discussions held at the Seminar and have been revised and updated. The proceedings are in Italian, which was the language of the seminar. In addition to the authors who took part in the seminar, several other scholars wished to contribute with a personal paper for this Complimentary Volume in honour of S.M. Pandey. These papers are both in English and Italian
Minimum+1 (s,t)-cuts and Dual Edge Sensitivity Oracle
No full textLet G be a directed multi-graph on n vertices and m edges with a designated source vertex s and a designated sink vertex t. We study the (s,t)-cuts of capacity minimum+1 and as an important application of them, we give a solution to the dual edge sensitivity for (s,t)-mincuts - reporting the (s,t)-mincut upon failure or addition of any pair of edges.
Picard and Queyranne [Mathematical Programming Studies, 13(1):8-16, 1980] showed that there exists a directed acyclic graph (DAG) that compactly stores all minimum (s,t)-cuts of G. This structure also acts as an oracle for the single edge sensitivity of minimum (s,t)-cut. Dinitz and Nutov [STOC, pages 509-518, 1995] showed that there exists an (n) size 2-level cactus model that stores all global cuts of capacity minimum+1. However, for minimum+1 (s,t)-cuts, no such compact structures exist till date. We present the following structural and algorithmic results on minimum+1 (s,t)-cuts.
1) There exists a pair of DAGs of size O(m) that compactly store all minimum+1 (s,t)-cuts of G. Each minimum+1 (s,t)-cut appears as a (s,t)-cut in one of the 2 DAGs and is 3-transversal - it intersects any path in the DAG at most thrice.
2) There exists an O(n²) size data structure that, given a pair of vertices {u,v} which are not separated by an (s,t)-mincut, can determine in (1) time if there exists a minimum+1 (s,t)-cut, say (A,B), such that {s,u} ∈ A and {v,t} ∈ B; the corresponding cut can be reported in (|B|) time.
3) There exists an O(n²) size data structure that solves the dual edge sensitivity problem for (s,t)-mincuts. It takes (1) time to report the value of a resulting (s,t)-mincut (A,B) and (|B|) time to report the cut.
4) For the data structure problems addressed in (2) and (3) above, we also provide a matching conditional lower bound. We establish a close relationship among three seemingly unrelated problems – all-pairs directed reachability problem, the dual edge sensitivity problem for (s,t)-mincuts, and 2× 2 maximum flow. Assuming the directed reachability hypothesis, this leads to Ω(n²) lower bounds on the space for the latter two problems
लीचिमा 2017
No full textNot AvailablePurbey, S.K., Pandey, S.D., Sharma, S., Verma, J.P. (2017). Litchima. First Edition. ICAR-National Research Centre on Litchi, Muzaffarpur; 72 p.Not Availabl
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
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