39 research outputs found

    Aqueous Two-Phase Extraction of Lipase from Rice Bran

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    This Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page

    SMARCA2 and THAP11: potential candidates for polyglutamine disorders as evidenced from polymorphism and protein-folding simulation studies

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    CAG repeat expansion is the cause of an ever-increasing list of neurodegenerative disorders, especially hereditary ataxias. However, genes responsible for 10–50% of the clinically diagnosed ataxias are still unidentified in different populations. Traditional linkage and repeat expansion-detection based methods complemented with human genome sequence and expression information can now accelerate the pace of identification of putative disease candidates. We have analyzed two CAG repeat containing loci, human SMARCA2 and THAP11, which are expressed in the brain as putative candidates for SCAs, using computational as well as polymorphism scanning approaches. Both loci exhibited features characteristic of genes associated with repeat disorders. These loci are polymorphic with respect to size and interruption pattern in the Indian population. Furthermore, computational analysis of glutamine-stretch embedded domains in the respective proteins predicted these regions to be “natively unfolded” beyond a threshold of 40 glutamines. Comparative genome analysis suggested a stabilizing influence of CAA interspersions in repeat tract in THAP11 but not in SMARCA2. Although repeat expansion could not be detected within these genes in unidentified ataxia patients reported in India, we suggest that these loci be screened in other populations, as there is a wide heterogeneity in the prevalence of these disorders in different populations

    A Preliminary Study of Agricultural Waste as Biochar Incorporated into Cementitious Materials: Preliminary study of agricultural waste as biochar incorporated cementitious materials for concrete structure

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    Incorporating small amounts of biochar into cementitious materials has partial effects on the environment. In this present study, rice husk was collected as agricultural biomass from a local area of Roorkee Uttarakhand, which contains siliceous material to a significant extent. Biochar was prepared from agricultural waste in a muffle furnace at a temperature of 500 ℃ for 90 min and ground to a fineness of less than 10 µm. Prior to incorporation into building envelopes such as mortar and concrete, a basic study on cement pastes is essentially required. For this purpose, different dosages of biochar such as 0, 3%, 5% and 10% wt. were replaced with cement in cementitious materials. Physical properties such as water absorption, density and porosity were investigated. Furthermore, mechanical and thermal properties such as compressive strength and thermal conductivity were studied. Advanced tools like field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD) and thermogravimetric analyzer (TGA) were used to identify the hydration products. As the dosages increased in the cement matrix, the physical properties of sample were increased and porosity decreased. The compressive strength of biochar incorporated cement paste improved according to 0, 3%, 5% and 10% wt. It further reveals that as the dosage increased, the thermal conductivity of the samples decreased significantly. Moreover, the sustainable assessment showed that biochar could reduce embodied carbon, embodied energy and strength efficiency substantially over the control sample. A satisfactory result was obtained at 5% wt. and 10 % wt. of biochar. The overall result revealed that biochar up to 10% wt. can be incorporated into mortar and concrete due to better results than the control mix

    Universal and automatic end-to-end testing of smart TVs

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    End-to-end testing of smart TVs has proven to be challenging due to various reasons, such as: the proprietary nature of hardware and software from different TV manufacturers; the difficulty of identifying performance bottlenecks due to visual rendering being performed by cloud-based renderers; etc. As a result, end-to-end testing of a smart TV still relies heavily on time-consuming and costly manual testing. This disclosure describes a framework for end-to-end testing of smart TVs that is automatic, e.g., uses minimal human intervention, and universal (agnostic to TV manufacturer)

    Effects of Low-Temperature Operation on the Performance of MOSFETs

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    abstract: The existing compact models can reproduce the characteristics of MOSFETs in the temperature range of -40oC to 125oC. Some applications require circuits to operate over a wide temperature range consisting of temperatures below the specified range of existing compact models, requiring wide temperature range compact models for the design of such circuits. In order to develop wide temperature range compact models, fourteen different geometries of n-channel and p-channel MOSFETs manufactured in a 0.18μm mixed-signal process were electrically characterized over a temperature range of 40 K to 298 K. Electrical characterization included ID-VG and ID-VD under different drain, body and gate biases respectively. The effects of low-temperature operation on the performance of 0.18μm MOSFETs have been studied and discussed in terms of sub-threshold characteristics, threshold voltage, the effect of the body bias and linearity of the device. As it is well understood, the subthreshold slope, the threshold voltage, drive currents of the MOSFETs increase when the temperature of the MOSFETs is lowered, which makes it advantageous to operate the MOSFETs at low-temperatures. However the internal linearity gm1/gm3 of the MOSFETs degrades as the temperature of the MOSFETs is lowered, and the performance of the MOSFETs can be affected by the interface traps that exist in higher density close to conduction band and valence band energy levels, as the Fermi-level moves closer to bandgap edges when MOSFETs are operated at cryogenic temperatures.Dissertation/ThesisM.S. Electrical Engineering 201
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