1,010 research outputs found
The feasibility analysis of YX real-estate project
No full textYX项目是本人任职的房地产公司的第一个房产项目。借助该项目所处的绝版地段，为了将该项目打造成为厦门市高尚住宅中的精品楼盘，投资者走访了中国许多城市的类似楼盘，在吸收众家的精华后将该项目赋之行动。本人从项目的前期调查开始参与了项目投资可行性分析的工作。本文结合厦门房地产开发的特点，对该项目进行可行性研究和投资评价。文章主要包括以下四个部分： 第一章YX项目的背景分析。主要分为项目的地理位置、项目的形象定位、项目建筑经济指标等三个方面。 第二章YX项目市场分析。本章主要从宏观政策分析、供求分析、竞争分析、定价分析等方面来预测YX项目的市场均价。 `第三章YX项目的成本费用预估。本章通过对一般...YX was the first project that a real estate company had in Xiamen. Depending on the unique location, the company decided to make it one of the perfect projects. For this sake, the investor had visited many similar projects in China and deflowered them. The author joined in the work team for the feasibility analysis of the project. The thesis studies the investment feasibility of the project and ev...学位：工商管理硕士院系专业：管理学院工商管理教育中心_工商管理硕士(MBA)学号：20031526
Squeezing properties of three-level atomic collective dipole phase quadrature operators with respect to three-level atomic coherent state
No full textWe add some useful formulations except for Ref. [4], then investigate the squeezing properties of the atomic collective dipole phase quadrature operators with respect to three-level atomic coherent state in detail. We mainly discuss two extreme cases concerning parameter alpha and beta and obtain some interesting conclusions.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000074837900005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Physics, MultidisciplinarySCI(E)中国科学引文数据库(CSCD)0ARTICLE4503-5102
Crystallite size-modulated exciton emission in SnO₂ nanocrystalline films grown by sputtering
No full textAuthor name used in this publication: Pan, Shu Sheng.Author name used in this publication: Yu, Siu Fung.2012-2013 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishedVoR allowe
Support properties of super-Brownian motions with spatially dependent branching rate
No full textAbstractWe consider a critical finite measure-valued super-Brownian motion X=(Xt,Pμ) in Rd, whose log-Laplace equation is associated with the semilinear equation (∂/∂t)u=12Δu−ku2, where the coefficient k(x)>0 for the branching rate varies in space, and is continuous and bounded. Suppose that suppμ is compact. We say that X has the compact support property, if Pμ⋃0⩽s⩽tsuppXsisbounded=1 for every t>0, and we say that the global support of X is compact if Pμ⋃0⩽s<∞suppXsisbounded=1. We prove criteria for the compact support property and the compactness of the global support. If there exists a constant M>0 such that k(x)⩾exp(−M||x||2) as ||x||→∞ then X possesses the compact support property, whereas if there exist constant β>2 such that k(x)⩽exp(−||x||β) as ||x||→∞ then X does not have the compact support property. For the global support, we prove that if k(x)=||x||−β(0⩽β<∞) for sufficiently large ||x||, then the maximum decay order of k for the global support being compact is different for d=1, d=2 and d⩾3: it is O(||x||−3) in dimension one, O(||x||−2(log||x||)−3) in dimension two, and O(||x||−2) in dimensions three or above
ENHANCED FLUORIMETRIC DETERMINATION OF EUROPIUM(III) WITH THENOYLTRIFLUOROACETONE AND 4,7-DIPHENYL-1,10-PHENANTHROLINE BY GADOLINIUM(III)
No full textChemistry, AnalyticalSCI(E)37ARTICLE81499-15132
The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells
No full textJin-Ping Li,1,2 Yin-Xue Yang,3 Qi-Lun Liu,1 Zhi-Wei Zhou,2,4 Shu-Ting Pan,2,5 Zhi-Xu He,4 Xueji Zhang,6 Tianxin Yang,7 Si-Yuan Pan,8 Wei Duan,9 Shu-Ming He,10 Xiao-Wu Chen,11 Jia-Xuan Qiu,5 Shu-Feng Zhou2,41Department of Surgical Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA; 3Department of Colorectal Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 4Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, Guizhou, People’s Republic of China; 5Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 6Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, People’s Republic of China; 7Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, UT, USA; 8Department of Pharmacology, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 9School of Medicine, Deakin University, Waurn Ponds, VIC, Australia; 10Department of Obstetrics and Gynecology, Xiaolan People’s Hospital affiliated to Southern Medical University, Zhongshan, Guangdong, People’s Republic of China; 11Department of General Surgery, The First People’s Hospital of Shunde affiliated to Southern Medical University, Shunde, Foshan, Guangdong, People’s Republic of China Abstract: Danusertib (Danu) is a pan-inhibitor of Aurora kinases and a third-generation breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (Bcr-Abl) tyrosine kinase inhibitor, but its antitumor effect and underlying mechanisms in the treatment of human breast cancer remain elusive. This study aimed to investigate the effects of Danu on the growth, apoptosis, autophagy, and epithelial-to-mesenchymal transition (EMT) and the molecular mechanisms in human breast cancer MCF7 and MDA-MB-231 cells. The results demonstrated that Danu remarkably inhibited cell proliferation, induced apoptosis and autophagy, and suppressed EMT in both breast cancer cell lines. Danu arrested MCF7 and MDA-MB-231 cells in G2/M phase, accompanied by the downregulation of cyclin-dependent kinase 1 and cyclin B1 and upregulation of p21 Waf1/Cip1, p27 Kip1, and p53. Danu significantly decreased the expression of B-cell lymphoma-extra-large (Bcl-xl) and B-cell lymphoma 2 (Bcl-2), but increased the expression of Bcl-2-associated X protein (Bax) and p53-upregulated modulator of apoptosis (PUMA), and promoted the cleavage of caspases 3 and 9. Furthermore, Danu significantly increased the expression levels of the membrane-bound microtubule-associated protein 1A/1B-light chain 3 (LC3-II) and beclin 1 in breast cancer cells, two markers for autophagy. Danu induced the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinases 1 and 2 (Erk1/2) and inhibited the activation of protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways in breast cancer cells. Treatment with wortmannin (a phosphatidylinositol 3-kinase inhibitor) markedly inhibited Danu-induced activation of p38 MAPK and conversion of cytosolic LC3-I to membrane-bound LC3-II. Pharmacological inhibition and small interfering RNA-mediated knockdown of p38 MAPK suppressed Akt activation, resulting in LC3-II accumulation and enhanced autophagy. Pharmacological inhibition and small interfering RNA-mediated knockdown of Erk1/2 also remarkably increased the level of LC3-II in MCF7 cells. Moreover, Danu inhibited EMT in both MCF7 and MDA-MB-231 cells with upregulated E-cadherin and zona occludens protein 1 (ZO-1) but downregulated N-cadherin, zinc finger E-box-binding homeobox 1 (TCF8/ZEB1), snail, slug, vimentin, and ß-catenin. Notably, Danu showed lower cytotoxicity toward normal breast epithelial MCF10A cells. These findings indicate that Danu promotes cellular apoptosis and autophagy but inhibits EMT in human breast cancer cells via modulation of p38 MAPK/Erk1/2/Akt/mTOR signaling pathways. Danu may represent a promising anticancer agent for breast cancer treatment. More studies are warranted to fully delineate the underlying mechanisms, efficacy, and safety of Danu in breast cancer therapy. Keywords: Danusertib, breast cancer, cell cycle, apoptosis, autophagy, EMT 
5Gb/s optical logic AND operations using by monolithically integrated photodiode and electroabsorption modulator
No full textMulti-quark states in the inherent nodal structure analysis
No full textThe strangeness s = +1 pentaquark states qqqq (q) over bar and the six-quark quark clusters qqqqqq are investigated. By analyzing the inherent nodal structure of the systems, the low-lying states are picked out. By comparing the accessibility of the nodeless states and referring the presently obtained K-N interaction potential, we propose that the quantum numbers of the lowest-lying pentaquark state Theta+ may be (J(P), T) = ((2)/(1),0) and L = 1. Meanwhile, the possible dibaryon states are briefly discussed.Physics, NuclearPhysics, Particles & FieldsSCI(E)CPCI-S(ISTP)
New phenanthrene glycosides from Dendrobium denneanum and their cytotoxic activity
No full textFive new phenanthrene glycosides, denneanosides A-E (1-5), and one new 9,10-dihydrophenanthrene glycoside, denneanoside F (6) were isolated from the stem of Dendrobium denneanum. The chemical structures of the new compounds were established on the basis of extensive spectroscopic data. The isolated compounds were evaluated for their in vitro cytotoxic activity against SNU387 hepatocellular carcinoma cell line. Compounds 1-3 showed moderate cytotoxic activities while compounds 4-6 showed weak activities. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V
Investigation of plasmonic whispering-gallery mode characteristics for graphene monolayer coated dielectric nanodisks
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