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    Inomogeneidade na distribuição da ventilação como preditor no teste de AVD-Glittre em mulheres com artrite reumatoide

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    A artrite reumatoide é uma doença crônica que acomete o tecido conjuntivo, apresentando sinais extra-articulares e lesões articulares progressivas. Considerada como autoimune, caracterizada como poliartrite destrutiva, podendo causar diversos níveis de comprometimento funcional. De uma maneira geral, a AR envolve simetricamente pequenas articulações, com dor, rigidez matinal e limitação dos movimentos por mais de uma hora. Entretanto, esses sinais podem variar de acordo com o paciente. Articulações metacarpofalangianas, articulações interfalangeanas proximais, punhos, articulações metatarsofalangeanas e joelhos são frequentemente mais acometidos, embora outras articulações possam ser afetadas. Além de comprometimento articulares, outras estruturas podem ser acometidas, como o sistema respiratório, vias aéreas, pleura e parênquima. Embora o envolvimento pulmonar seja a manifestação extra-articular mais comum na artrite reumatoide (AR), os testes de função pulmonar tradicionais não mostram boa correlação com os testes de campo usualmente realizados nestes pacientes. Nas últimas décadas, cada vez mais tem sido incorporadas a medida da inomogeneidade da distribuição da ventilação através do teste do washout do nitrogênio em respiração única (N2SBW) e, também, a avaliação da capacidade funcional ao exercício através do teste de atividade de vida diária-Glittre (TA-G). Para investigar a contribuição da inomogeneidade da ventilação na performance durante o exercício, 43 mulheres com AR submeteram ao teste de N2SBW e ao T-AG; além do mais, elas realizaram a espirometria, a medida da capacidade de difusão do dióxido de carbono (DLco), a medida de força muscular respiratória e a avaliação da função física através do índice de capacidade do questionário de avaliação em saúde (HAQ-DI). O tempo de TA-G apresentou correlações significativas com DLco (rs = -0,397, P = 0,008), capacidade vital forçada/DLco (rs = 0,307, P = 0,044), slope de fase III do teste do N2SBW (SIIIN2, rs = 0,644, P < 0,0001) e HAQ-DI (rs = 0,482, P = 0,001). Na análise de regressão múltipla, o SIIIN2 e o HAQ-DI foram as únicas variáveis preditivas para tempo de TA-G, explicando 40% de sua variabilidade. Embora a extensão da doença na tomografia computadorizada tenha se associado com o tempo de TA-G, não houve correlações significantes entre o tempo do diagnóstico e a atividade de doença com o tempo de TA-G. Em conclusão, o TA-G pode ser uma medida mais válida do status funcional em pacientes com AR, podendo refletir com maior fidedignidade o dano da função pulmonar.A rheumatoid arthritis is a chronic disease that affects the connective tissue, presents extra-articular signs and progressive joint injuries. Considered as autoimmune, characterized as destructive polyarthritis, which can cause different levels of functional impairment. In general, an RA symmetrically involves small joints, with pain, morning stiffness and limited movement for more than an hour. However, these signs may vary according to the patient. Metacarpophalangeal joints, proximal interphalangeal joints, wrists, metatarsophalangeal joints and knees are often more affected, although other joints may be affected. In addition to joint involvement, other structures may be affected, such as the respiratory system, airways, pleura and parenchyma.Although pulmonary involvement is the most common extra-articular manifestation of rheumatoid arthritis (RA), traditional pulmonary function testsdo not show a good correlation with the field tests usually performed in these patients. In recent decades, there has been increasing use of the measurement of ventilation distribution inhomogeneity through the nitrogen single-breath washout (N2SBW) test and, also, of the evaluation of functional capacity during exercise using the Glittre- activities of daily living test (GA-T). To investigate the contribution of ventilation inhomogeneity to exercise performance, 43 women with RA underwent the N2SBW test and the GA-T; in addition, they underwent spirometry, measurement of diffusing capacity for carbon monoxide (DLco), measurement of respiratory muscle strength, and evaluation of physical function through the Health Assessment Questionnaire Disability Index (HAQ-DI). The GA-T time showed significant correlations with DLco (rs = -0.397, P = 0.008), forced vital capacity/DLco (rs = 0.307, P = 0.044), phase III slope of the N2SBW test (SIIIN2, rs = 0.644, P < 0.0001) and HAQ-DI (rs = 0.482, P = 0.001). In the multiple regression analysis, SIIIN2 and HAQ-DI were the only variables predictive of GA-T time, explaining 40% of its variability. In conclusion, although the extent of the disease as assessed by computed tomography was associated with the GA-T time, there were no significant correlations between the time since diagnosis or disease activity with GA-T time. Thus, the GA-T may be a more valid measure of functional status in patients with RA and may more reliably reflect damage to lung function.Coordenação de Aperfeiçoamento de Pessoal de Nível Superio

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Author Index

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    koamabayili/VECTRON-author-checklist: VECTRON author checklist

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    We have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used

    Author Under Sail The Imagination of Jack London, 1893-1902

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    In Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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