32,503 research outputs found
"3. Storia. Introduzione" e scheda critica su C.S. Maier, La rifondazione dell'Europa borghese. Francia, Germania, Italia nel decennio successivo alla Prima Guerra Mondiale
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Maria Bersani
No full textLa voce illustra la biografia e l'apporto letterario dato da Maria Bersani alla letteratura per l'infanziaThe headword explains the biography and the contribution of the author Maria Bersani to the children's literatur
Fuentes de resistencia a podredumbre verde (Penicillium allii) en variedades de ajo
No full textLa podredumbre verde del ajo, causada Penicillium allii, es una de las principales enfermedades
fúngicas que afecta esta hortaliza en la mayoría de los países productores del mundo. La
enfermedad puede ocasionar importantes pérdidas económicas, tanto en cultivo en campo como
durante la conservación de los ajos en secaderos y galpones de empaque.
Se evaluaron los principales cultivares nacionales de ajo, desarrollados por el INTA La Consulta y
la Facultad de Ciencias Agrarias de la Universidad Nacional de Cuyo, según su respuesta frente a
infecciones inducidas (inoculaciones con esporas del hongo).EEA La ConsultaFil: Salinas Palmieri, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza; ArgentinaFil: Salinas Palmieri, Maria Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Consulta; ArgentinaFil: Cavagnaro, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza; ArgentinaFil: Cavagnaro, Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Consulta; Argentin
Scenari e retorica dei conflitti nel teatro italiano tra Seicento e Novecento
No full textLa rappresentazione della guerra e della pace nella letteratura teatrale e nelle drammaturgie d’età moderna e contemporanea, con particolare riguardo all’Ermegildo di Emanuele Tesauro, all’Alcesti di A. Savinio e al teatro di Dario Fo
CfDNA-NGS Liquid Biopsy for solid cancers and vascular malformations
No full textThe liquid biopsy is a new emerging and repeatable low risky approach able to detect drive mutations that characterize the tumor, to monitor cancer evolution over time, and to overcome the standard tissue biopsy limits. The biomarker par excellence is the circulating cell-free DNA (cfDNA) that was the principal leading actor of this study. The scope of this study was to perform different liquid biopsy analysis both in metastatic cancer and in vascular malformations patients to detect, from a precision medicine perspective, the sniper clone responsible for the tumor evolution or the vascular malformations. The cfDNA was extracted from plasma coming from peripheral and/or efferent vein of vascular malformation. The obtained cfDNA was used to perform the libraries using two different genes panel of 52 and 77 cancer-driver genes, respectively the OncomineTM Pan-Cancer Cell-Free Assay and AVENIO ctDNA Expanded Kit. The most frequent mutations that we found in metastatic patients were the SNV in TP53, follow by PIK3CA, KRAS, and CNV in FGFR3. In the majority of cases, the mutations found at first liquid biopsy were confirmed by an increased allele frequency at the second one. In vascular anomalies affected patients, the PIK3CA, MET, and KRAS mutated genes were found in Klippel-Trenaunay syndrome, in lymphovenous malformations, and in artero-venous malformations respectively, with a very low allele frequency percentage. In conclusion, repeated analysis of liquid biopsy lead to the identification of key cancer genes and the following of clonal evolution over time. Moreover, the liquid biopsy is suitable not only for cancer patients but also for the diagnosis of vascular malformation. Our data prove that in the new era of precision medicine, this novel approach, based on the combination of NGS and liquid biopsy from the efferent vein at the vascular malformation site, allows to detect even low-grade somatic mosaicism responsible for the vascular phenotype. This approach let to bypassing the need for a highly risky tissue biopsy and lead to a tailored personalized treatment
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