1,721,075 research outputs found
Correction to: Can novel CT-and MR-based neuroimaging biomarkers further improve the etiological diagnosis of lobar intra-cerebral hemorrhage?
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Imaging biomarkers in neuro-oncology : towards a translational approach of diffuse gliomas
No full textLes gliomes diffus sont les tumeurs cérébrales les plus fréquemment rencontrées en pratique clinique quotidienne. Dans ce travail de Thèse de Neurosciences, nous avons cherché à identifier des biomarqueurs IRM de prédiction spécifiquement dédiés à ces tumeurs. A travers 6 articles scientifiques originaux, nous avons pu identifier de multiples biomarqueurs IRM appliqués aux gliomes diffus. Ainsi par nos deux premiers travaux, nous avons défini la présence d'une anomalie veineuse de développement comme un « biomarqueur spontané » de prédisposition aux gliomes diffus de l'enfant et de l'adulte. Notre troisième travail a défini la topographie tumorale comme un « biomarqueur spatial » dans les glioblastomes supra-tentoriels, IDH-non mutés de l'adulte qui regroupe les principaux facteurs pronostiques connus et, à travers la réalisation d'un cartographie probabiliste tridimensionnelle, nous avons pu identifier les régions à risque épileptique, les régions préférentiellement atteintes par ces tumeurs ainsi que les facteurs influencés par la topographie tumorale comme la procédure chirurgicale, l'étendue de résection, l'indépendance fonctionnelle pré-opératoire, l'âge des patients et les données de survie. Notre quatrième travail a permis de définir la cinétique de croissance tumorale spontanée des oligodendrogliomes, IDH-mutés, 1p/19q-co-délétés comme « biomarqueur temporel » permettant ainsi la distinction entre grade II et III, mais aussi en établissant un seuil au-delà duquel un oligodendrogliome peut être considéré comme étant anaplasique. Il nous a permis de distinguer les oligodendrogliomes de grade III avec néoangiogénèse, de ceux ayant un compte mitotique accru uniquement et enfin de ceux considérés comme étant de grade II. Il nous a permis d'identifier des oligodendrogliomes « à croissance rapide », mais également de définir le lien entre la cinétique de croissance et la survie des patients. Enfin, nous avons pu proposer un nouveau seuil de mitoses pour la caractérisation anaplasique des oligodendrogliomes pour la nouvelle Classification OMS 2021. Notre cinquième travail a défini la néoangiogénèse radio-histologique comme un « biomarqueur vasculaire » dans les astrocytomes de l'adulte. Ce travail a validé l'importance pronostique de la Classification OMS 2016 et des mises à jour cIMPACT-NOW qui tiennent compte des données bio-moléculaires récentes. Il nous a permis de proposer l'intégration en routine clinique d'une évaluation combinée de la néoangiogénèse radio-histologique dans l'évaluation de la représentativité de l'échantillonnage tumoral de même qu'il nous a permis d'identifier trois nouveaux sous-groupes de glioblastomes moléculaires. Enfin, ce travail a validé l'impact, en termes de survie, du type de prise de contraste observé sur l'IRM pré-opératoire. Notre sixième et dernier travail a permis la caractérisation clinico-radio-histo-moléculaire et épigénétique des gliomes de haut grade de l'adolescent et du jeune adulte définissant ainsi l'importance de l'étendue de résection chirurgicale dans les gliomes de haut grade dans cette population mais également des données bio-moléculaires récentes. Il nous a permis d'identifier les différents sous-types histo-moléculaires présents dans cette tranche d'âge en insistant sur le caractère spécifique des gliomes H3G34-mutés dans cette population. Grâce à ce travail de Thèse de Neurosciences, nous avons pu constater, dans la lignée des travaux historiques de l'école de Sainte-Anne, le rôle central de l'analyse des paramètres d'imagerie dans les gliomes diffus à l'ère du diagnostic histo-bio-moléculaire et épigénétique. L'ensemble de ces travaux plaide pour l'existence d'un corrélat fort entre les données cliniques, d'imageries, histologiques, moléculaires et épigénétiques et pour l'intégration de chacun de ces paramètres dans une vision holistique pour optimiser la classification de ces tumeurs et, in fine, optimiser la prise en charge thérapeutique des patients.Diffuse gliomas are the most common brain tumors encountered in daily clinical practice. In this Doctoral Thesis, we sought to identify predictive MRI biomarkers specifically dedicated to these tumors. Through 6 original scientific articles, we were able to identify multiple MRI biomarkers applied to diffuse gliomas. Thus, in our first two studies, we defined the presence of a developmental venous anomaly as a "spontaneous biomarker" of predisposition to diffuse gliomas in children and adults. Our third work has defined tumor topography as a "spatial biomarker" in supratentorial, glioblastomas IDH-wildtype in adults which brings together the main known prognostic factors. Through the realization of a three-dimensional probabilistic mapping, we were able to identify the regions at risk of epilepsy, the regions preferentially affected by these tumors as well as the factors influenced by the tumor topography such as the surgical procedure, the extent of resection, the preoperative functional independence, the age of the patients and survival data. Our fourth work made it possible to define the kinetics of spontaneous tumor growth of oligodendrogliomas, IDH-mutants, 1p/19q-co-deleted as a "temporal biomarker" thus allowing the distinction between grade II and III, but also by establishing a threshold beyond of which an oligodendroglioma can be considered to be anaplastic. It enabled us to distinguish grade III oligodendrogliomas with neoangiogenesis, from those with an increased mitotic count only and finally from those considered to be grade II. It allowed us to identify "fast growing" oligodendrogliomas, but also to define the link between growth kinetics and patient survival. Finally, we were able to propose a new mitosis threshold for the anaplastic characterization of oligodendrogliomas for the new WHO Classification 2021. Our fifth work defined radio-histological neoangiogenesis as a "vascular biomarker" in adult astrocytomas. This work validated the prognostic importance of the 2016 WHO Classification and cIMPACT-NOW updates which take into account recent bio-molecular data. It allowed us to propose the integration in clinical routine of a combined evaluation of radio-histological neoangiogenesis in the evaluation of the representativeness of the tumor sampling as well as it allowed us to identify three new subgroups of molecular glioblastomas. Finally, this work validated the impact, in terms of survival, of the type of contrast enhancement observed on preoperative MRI. Our sixth work has enabled the clinico-radio-histo-molecular and epigenetic characterization of high-grade gliomas in adolescents and young adults, thus defining the importance of the extent of surgical resection in high-grade gliomas in this population but also recent bio-molecular data. It allowed us to identify the different histo-molecular subtypes present in this age group, emphasizing the specific character of H3G34-mutant gliomas in this population. Thanks to this Doctoral work, we were able to observe, in line with the historical work of the Sainte-Anne Hospital, the central role of the analysis of imaging parameters in diffuse gliomas in the era of histo-bio-molecular and epigenetic diagnosis. All of this work argues for the existence of a strong correlate between clinical, imaging, histological, molecular and epigenetic data and for the integration of each of these parameters into a holistic vision to optimize the classification of these tumours and, in fine, optimize the therapeutic management of patients
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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