101,981 research outputs found
The natural history of asymptomatic ventricular preexcitation in children. A long-term electrophysiologic-based follow-up study for risk stratification
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Evaluate results of the simulation game "Earthquake for Kids"
No full textEarthquake for Kids (E4K) is a simulation game designed in 2011 by F. Paglino, B. Pace and D. D’Amato, under
the supervision of prof.ssa P. Rizzi on the model of Urban Simulation Games previously used in environmental
education (Rizzi 2003, 2011 – ISPRA 2011 – Pace et al. 2011 – Paglino and Rizzi 2013).
E4K was experienced with secondary schools of first and second grade of L’Aquila in 2011 (2 years after the M6.3
L’Aquila earthquake) and Pescara in 2014 and 2016.
During the game participants are asked to decide an urban development plan in a high seismic risk area. A debriefing
conference usually takes place in the same day or the day after.
By the game teenagers learn optimal strategies regarding urban development and environmental protection; they
also develop the control and management of environmental emergencies; finally they improve knowledge of seismic
risk of their own region.
In order to assess the efficacy of this educative strategy, 60 high school students of Pescara were involved in
the game (May 2016) and completed a battery of ex-ante/ex-post questionnaires : the Seismic Risk Perception
Questionnaire (SRP-Q, Crescimbene et al. 2013); the General Ecological Behavior (GEB) (Kaiser, 1998); a questionnaire
to assess ecologist thinking, New Human Interdipendency Paradigm (NHIP; Corral-Verdugo, Carrus,
Bonnes, Moser, Sinha, 2008).
In this paper we discuss the E4K’s capability to promote in teenagers both an accurate seismic risk perception and
adequate environmental protection strategies.UnpublishedTrieste, Italia7IT. Educazione e divulgazione scientificaope
Ranpirnase and its potential for the treatment of unresectable malignant mesothelioma
No full textRibonucleases are a superfamily of enzymes which operate at the crossroads of transcription and translation, catalyzing the degradation of RNA; they can be cytotoxic because the cleavage of RNA renders indecipherable its information. Ranpirnase is a novel ribonuclease which preferentially degrades tRNA, thus leading to inhibition of protein synthesis and, ultimately, to cytostasis and cytotoxicity. Ranpirnase has demonstrated antitumor activity both in vitro and in vivo in several tumor models. The maximum tolerated dose emerging from phase I studies was 960 g/m2, with renal toxicity as the main dose-limiting toxicity. A large phase II trial showed that ranpirnase has disease-modifying activity against malignant mesothelioma. Ranpirnase proved to be superior to doxorubicin in a phase III trial, while preliminary results of another large, phase III trial, suggest that the combination of ranpirnase and doxorubicin could be more effective than doxorubicin alone. In all the above studies, ranpirnase seems to act mainly as a cytostatic rather than a cytotoxic drug, stabilizing progressive disease and potentially prolonging patients' survival. Ranpirnase may thus find its niche in combination with doxorubicin for mesothelioma as a second-line therapy, where no standard of care presently exists. © 2008 Dove Medical Press Limited. All rights reserved
[Efficacy of cyproheptadine in the therapy of essential headache in the developmental age]
No full textComplex Investigation of a Pediatric Haematological Case: Haemophagocytic Syndrome Associated with Visceral Leishmaniasis and Epstein−Barr (EBV) Co-Infection
No full textBACKGROUND:
Visceral leishmaniasis (VL) is an anthropozoonosis caused by an intracellular parasite belonging to the genus Leishmania. In the Mediterranean region, L. donovani and L. infantum are responsible for VL and dogs are the main reservoir. Haemophagocytic lymphohistiocytosis (HLH) represents a complication of VL and consists of unrestrained activation and proliferation of lymphocytes and macrophages, leading to uncontrolled immune activation. Haemophagocytic lymphohistiocytosis may also develop during viral infection, and Epstein−Barr virus (EBV) infection is one of the main HLH causes. Macrophage haemophagocytosis in the bone marrow aspirate is pathognomonic.
CASE PRESENTATION:
The case involves a 19-month-old male infant presenting with a high persistent fever with a fluctuating pattern, pancytopaenia, hepatosplenomegaly, and a high triglyceride level. Initial investigations showed an EBV infection. Considering the persistent signs and symptoms, bone marrow aspiration was performed and confirmed the suspicion of HLH. In addition, the presence of Leishmania infection was shown. The patient was treated with liposomal amphotericin B and had complete resolution of his symptoms.
CONCLUSION:
Diagnosis of VL represents a demanding challenge in endemic and non-endemic areas. Our case demonstrates that leishmaniasis should always be considered in the differential diagnosis in patients presenting with hepatosplenomegaly and cytopaenia with a persistent fever, even in cases of infectious mononucleosis. Moreover, the execution of bone marrow aspiration should not be delayed in order to diagnose and treat at an early stage the potential occurrence of VL, especially if complicated with HLH
L. Studer, S. Agriesti, M. Ponti, P. Gandini, G. Marchionni, F. Borghetti, V. Paglino, R. Maja, M. Bruglieri, “Evaluation approach for a combined implementation of Day 1 C-ITS and Highway Chauffeur – v.1.0.,” Ex-Ante Evaluation Report, C-Roads Italy Platform, 2018.
No full textL. Studer, S. Agriesti, M. Ponti, P. Gandini, G. Marchionni, F. Borghetti, V. Paglino, R. Maja, M. Bruglieri, “Evaluation approach for a combined implementation of Day 1 C-ITS and Truck Platooning – v.1.0.,” Ex-Ante Evaluation Report, C-Roads Italy Platform, 2018
No full textDYNAMIC CT INTEGRATION WITH CARTO MAPPING SYSTEM FOR ATRIAL FIBRILLATION ABLATION. VALIDATION OF THE TECHNIQUE IN HUMANS
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