198 research outputs found

    Erratum: Immunogenicity, antigenicity and epitope mapping of Salmonella InvH protein: An in silico study

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    There was an error in the author list of the published article. Two authors (T Hashempour, Z Hasanshahi) requested to remove from the authors lists. After obtaining the agreement of the authors and the corresponding author, Editor-in-Chief accept the corrections as listed below. The correct author list is: Behzad Dehghani, Iraj Rasooli   We apologize for any inconvenience this may have caused.   Erratum for: Immunogenicity, antigenicity and epitope mapping of Salmonella InvH protein: An in silico study B Dehghani, T Hashempour, Z Hasanshahi, I Rasooli J Curr Biomed Rep. 2020; 1(1): 9-16

    Problemas y desafíos de las organizaciones no gubernamentales en la ciudad de Pune, estado de Maharashtra, India

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    In India, Non-Governmental Organizations are seen to have a significant role in community development practice. NGOs are established with a vision by a group of like-minded people committed for community development, uplift of poor people. Importance of NGOs in various fields and the excellent work is done by NGOs in specific fields is no doubt a good task that has helped to meet the changing needs of the two-day special structure. But, nowadays, many NGOs in India is facing various problems and challenges which are creating barriers in the implementation of various developmental programs. In this context and efforts have been made through this study to focus on the major problems or challenges facing by Indian NGOs. The result of the study shows that NGOs are facing financial, problems, HR related challenges, administrative and social problems in the implementation of various social developmental programs.En la India, se considera que las organizaciones no gubernamentales tienen un papel importante en la práctica del desarrollo comunitario. Las ONG se establecen con una visión de un grupo de personas de ideas afines comprometidas con el desarrollo de la comunidad, la elevación de las personas pobres. La importancia de las ONG en diversos campos y el excelente trabajo realizado por las ONG en campos específicos es sin duda una buena tarea que ha ayudado a satisfacer las necesidades cambiantes de la estructura especial de dos días. Pero, hoy en día, muchas ONG en India enfrentan varios problemas y desafíos que crean barreras en la implementación de varios programas de desarrollo. En este contexto, se han realizado esfuerzos a través de este estudio para centrarse en los principales problemas o desafíos que enfrentan las ONG indias. El resultado del estudio muestra que las ONG se enfrentan a problemas financieros, problemas relacionados con los recursos humanos, problemas administrativos y sociales en la implementación de diversos programas de desarrollo social

    Optimizing parallel I/O performance of HPC applications

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    Parallel I/O is an essential component of modern High Performance Computing (HPC). Obtaining good I/O performance for a broad range of applications on diverse HPC platforms is a major challenge, in part because of complex inter-dependencies between I/O middleware and hardware. The parallel file system and I/O middleware layers all offer optimization parameters that can, in theory, result in better I/O performance. Unfortunately, the right combination of parameters is highly dependent on the application, HPC platform, and problem size/concurrency. Scientific application developers do not have the time or expertise to take on the substantial burden of identifying good parameters for each problem configuration. They resort to using system defaults, a choice that frequently results in poor I/O performance. We expect this problem to be compounded on exascale class machines, which will likely have a deeper software stack with hierarchically arranged hardware resources. We present a line of solution to this problem containing an autotuning system for optimizing I/O performance, I/O performance modeling, I/O tuning, I/O kernel generation, and I/O patterns. We demonstrate the value of these solution across platforms, applications, and at scale.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2017-12-01The student, Babak Behzad, accepted the attached license on 2015-11-20 at 13:31.The student, Babak Behzad, submitted this Dissertation for approval on 2015-11-20 at 13:45.This Dissertation was approved for publication on 2015-11-23 at 13:41.DSpace SAF Submission Ingestion Package generated from Vireo submission #8816 on 2016-03-02 at 14:06:01Made available in DSpace on 2016-03-02T20:23:36Z (GMT). No. of bitstreams: 4 BEHZAD-DISSERTATION-2015.pdf: 2579773 bytes, checksum: e393f126dc8ca1229a99a983f6997d0b (MD5) ProQuestSign-BabakBehzad.pdf: 268035 bytes, checksum: f29cad9dd3b5d70629f7fa2b72875efc (MD5) BabakBehzad_CS_PhDThesis_Final_2015.zip: 19558300 bytes, checksum: ab9daeaa06c6144e16b86542046ac95e (MD5) LICENSE.txt: 4209 bytes, checksum: 648e218a7b53159b5f1fbf5c97c5c231 (MD5) Previous issue date: 2015-11-23Embargo set by: Seth Robbins for item 91322 Lift date: 2018-03-02T20:24:31Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 91322 on 2018-03-03T10:15:34Z

    Problems and Challenges of Non-Governmental Organizations in Pune City, State of Maharashtra, India

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    In India, Non-Governmental Organizations are seen to have a significant role in community development practice. NGOs are established with a vision by a group of like-minded people committed for community development, uplift of poor people. Importance of NGOs in various fields and the excellent work is done by NGOs in specific fields is no doubt a good task that has helped to meet the changing needs of the two-day special structure. But, nowadays, many NGOs in India is facing various problems and challenges which are creating barriers in the implementation of various developmental programs. In this context and efforts have been made through this study to focus on the major problems or challenges facing by Indian NGOs. The result of the study shows that NGOs are facing financial, problems, HR related challenges, administrative and social problems in the implementation of various social developmental programs.En la India, se considera que las organizaciones no gubernamentales tienen un papel importante en la práctica del desarrollo comunitario. Las ONG se establecen con una visión de un grupo de personas de ideas afines comprometidas con el desarrollo de la comunidad, la elevación de las personas pobres. La importancia de las ONG en diversos campos y el excelente trabajo realizado por las ONG en campos específicos es sin duda una buena tarea que ha ayudado a satisfacer las necesidades cambiantes de la estructura especial de dos días. Pero, hoy en día, muchas ONG en India enfrentan varios problemas y desafíos que crean barreras en la implementación de varios programas de desarrollo. En este contexto, se han realizado esfuerzos a través de este estudio para centrarse en los principales problemas o desafíos que enfrentan las ONG indias. El resultado del estudio muestra que las ONG se enfrentan a problemas financieros, problemas relacionados con los recursos humanos, problemas administrativos y sociales en la implementación de diversos programas de desarrollo social

    Competition in dual-channel supply chains: The manufacturers' channel selection

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    © 2020 The Author(s) Innovative selling channels have brought about opportunities as well as challenges for upstream manufacturers. The past few years have witnessed both the success and failure of manufacturers with different channel strategies. To explore the rationale of different channel strategies in various contexts, we develop a model to analyze a manufacturer's channel selection decision among three channel strategies, i.e., a direct-channel strategy, a retail-channel strategy, and a dual-channel strategy consisting of both direct and retail channels. The model rests on the channel differentiation in terms of consumers’ channel preferences and operating costs of retail and direct channels. Specifically, we incorporate the action of a competitor and track down its influence on the focal manufacturer's channel preference. Our research clarifies the role of competition in the market and offers insights into the competitive nature of business in real life. Results show that the manufacturer's channel preference depends not only on the channels’ operating costs and consumers’ channel preferences but also on the competitor's channel strategy. We find that symmetric manufacturers can adopt asymmetric strategies as Nash equilibria and also that there are situations where no Nash equilibrium exists. We characterize the Nash equilibria in the channel selection game based on the exogenous parameters of the model

    Cytokine-mediated FOXO3a phosphorylation suppresses FasL expression in hemopoietic cell lines: Investigations of the role of Fas in apoptosis due to cytokine starvation

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    We have investigated phosphatidylinositol 3-kinase (PI3K)-dependent survival signalling pathways using several cytokines in three different hemopoietic cell lines, MC/9, FDC-P1, and TF-1. Cytokines caused PI3K- and PKB-dependent phosphorylation of FOXO3a (previously known as FKHRL1) at three distinct sites. Following cytokine withdrawal or PI3K inhibition, both of which are known to lead to apoptosis, there was a loss of FOXO3a phosphorylation, and a resulting increase in forkhead transcriptional activity, along with increased expression of Fas Ligand (FasL), which could be detected at the cell surface. Concurrently, an increase in cell surface expression of Fas was also detected. Despite the presence of both FasL and Fas, there was no detectable evidence that activation of Fas-mediated apoptotic events was contributing to apoptosis resulting from cytokine starvation or inhibition of PI3K activity. Thus, inhibition of FOXO3a activity is mediated by the PI3K–PKB pathway, but regulation of FasL is not the primary means by which cell survival is regulated in cytokine-dependent hemopoietic cells. We were also able to confirm increased expression of known FOXO3a targets, Bim and p27kip1. Together, these results support the conclusion that mitochondrial-mediated signals play the major role in apoptosis of hemopoietic cells due to loss of cytokine signalling. [ABSTRACT FROM AUTHOR]Peer reviewedfinal article publishedCytokineSignal transductionapoptosisTranscription factorProtein kinas

    Bilingualism, Monolingualism and Social Health: A Comparative Study Behzad Khedri , Farideh Sadat Momeni Masuole

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    dimensions in the two groups of students in favor of bilingual students, and the variables such as age, marriage, field of study, socioeconomic status, religious beliefs and communication skills were influential on the social health of both groups. Also, the results of the regression showed that 29% of the influence on the dependent variable of this study was interpreted by the independent variables. In addition, the communication skill is the strongest variable predictor with a rate of 66%. Keyword: Social Health, Social Integration, Students, Language   Bilingualism, Monolingualism and Social Health: A Comparative Study Behzad Khedri[1]  ,  Farideh Sadat Momeni Masuole[2] Received: 18/2/2017                   Accepted: 30/4/2018   Abstract There are mental influencing factors among students in the educational context such as educational stress, ethnic and cultural contradictions and the existence of political, belief, racial as well as gender discrimination, which can affect various aspects of student life and the health of this stratum, especially their social dimension could be endangered. Regarding the relationship between language, as a fundamental cultural component, and social health which has not been studied in social health research. In other words, the language of different ethnicities can provide unity, integrity, coherence and participation, or can a common language affect health and its social dimension or not? This study aims to answer the mentioned question by investigating bilingual students (ethnicities) and the monolinguals (those who speak only one language). In the following, we intend to explain what factors affect the social health of each group? The method of this study was survey and data was collected through questionnaires. The statistical population is Sanandaj University students and the sample included 384 individuals by the Cochran formula. The results of this study showed that there is a significant difference between the total social health and its [1]. PhD Student of Social Work, AllamehTabatabaiiUniversity, Tehran.     (Corresponding Author).   [email protected] [2]. Master of Sociology, ShahedUniversity.    [email protected]

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    What is important for consumers' energy-related decisions? A cross-sectoral systematic review and meta-analysis for the Nordic countries

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    | openaire: EC/HE/101056306/EU//IAM COMPACT Publisher Copyright: © 2024 The Author(s)The energy transition is shaped by the decisions of individuals. These decisions, in turn, are influenced by a diverse set of factors that have been the object of various studies reported in the literature. Most of these studies have, however, focused on a single decision or a sector. Here, we conduct for the Nordic countries a systematic literature review and a meta-analysis of factors affecting four important consumers' energy-related decisions, namely (1) the choice between an electric or a conventional vehicle, (2) mode choice for personal transport, (3) choice of heating system, and (4) deployment of energy-saving measures at home. We aim to identify the implications that certain factors may have for many of such decisions, potentially encouraging some while discouraging others. Our analysis shows that a group of factors, such as attitude, comfort, costs, living in a detached house, emission implications of the choice, perceived behavioral control, environmental friendliness of the technology, and subjective norm, affect multiple decisions uniformly, in terms of the direction of effect the factor has on environmentally benign decisions. There are, however, also factors for which trade-offs exist, for example, while better public transport infrastructure encourages the use of public transport use, it discourages walking and cycling. We also show differences in outcomes between revealed and stated preferences surveys. Our analysis shows that for electric vehicle adoption, the statistical significance of factors typically increases when excluding the stated preferences surveys. Finally, our findings can aid policymakers in crafting more effective interventions to meet climate targets.Peer reviewe
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