1,720,960 research outputs found
Clinical phenotypes of Behçet’s syndrome in a large cohort of Italian patients: focus on gender differences
No full text: Objective: The aim of this study was to investigate the clinical phenotypes of Italian patients with Behçet's syndrome (BS) according to gender. BS is a rare chronic multisystemic disorder with a wide spectrum of clinical manifestations. Human leucocyte antigen (HLA)-B51, gender, and ethnicity have been suggested as factors that could influence the clinical manifestations in BS patients. To date, few data assessing gender differences in Italian BS patients are available in the literature.Method: We retrospectively evaluated a group of Italian patients seen consecutively at our dedicated tertiary centre from 1 January 2000 to 31 May 2018. Demographics, clinical features during follow-up, and HLA status were obtained from a review of medical records and analysed in male and female groups.Results: In total, 285 [168 male (M) and 117 female (F)] patients were eligible for the study. Males had papulopustolar lesions, posterior uveitis, and deep venous thrombosis more often than females (83.3% M vs 46.2% F, 36.9% M vs 18.8% F, and 8.3% M vs 0.9% F, respectively; p < 0.01). Erythema nodosum (59.0% F vs 41.1% M; p < 0.01) and arthralgia (52.1% F vs 31.6% M; p < 0.01) were more frequent in females. No differences were found in HLA-B51 status (59.2% M vs 59.0% F).Conclusion: In our Italian cohort, BS was slightly more prevalent in males. Some gender-related differences were observed when comparing male and female cohorts. The data also confirmed that BS tends to be less aggressive in Italian female patients
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Attività esterasica, lipolitica e proteolitica in Armoracia rusticana
No full textIntroduzione
Armoracia rusticana (comunemente nota come rafano) è una specie, appartenente alla famiglia delle Brassicaceae, caratterizzata dall'ampio uso sia per scopi etnomedicali che culinari. Il caratteristico gusto pungente che contraddistingue la sua radice deriva dall'abbondanza in glucosinolati. Ad oggi l'interesse verso questa specie, oltre che per la sua ricchezza in enzimi come la perossidasi, una glicoproteina comunemente utilizzata in ambito analitico, è rivolto soprattutto verso altre sostanze bioattive quali vitamine, minerali, isotiocianati e antiossidanti. In questo lavoro è stata valutata l'attività antiossidante negli estratti di A. rusticana ed il contenuto totale in polifenoli ed in flavonoidi. Inoltre, è stata determinata la presenza di attività enzimatiche poco investigate in questa specie come esterasi, lipasi e proteasi.
Materiali e metodi
In questo studio sono stati analizzati quattro differenti genotipi di A. rusticana, raccolti in un areale di Accettura (provincia di Matera, Basilicata). Le analisi sono state condotte sugli estratti acquosi e metanolici, ottenuti a partire dalle radici ridotte in polvere con azoto liquido e conservate a -80°C fino al momento delle analisi. Il contenuto totale in polifenoli ed in flavonoidi è stato determinato rispettivamente con il reagente di Folin-Ciocalteau e con il saggio dell'AlCl3. L'attività antiossidante è stata valutata mediante i test del FRAP e dell'ABTS. Le attività esterasica e lipolitica sono state determinate per via spettrofotometrica valutando la quantità di p-nitrofenolo liberato da diversi substrati sintetici (Sigma). L'attività proteolitica è stata determinata sia in soluzione che mediante zimografia utilizzando la gelatina come substrato.
Risultati
Nei quattro genotipi analizzati, l'attività antiossidante determinata con i metodi FRAP e ABTS è compresa rispettivamente tra 170-330 e 640-1000 mg a. ascorbico equivalente/g, mentre il contenuto in polifenoli totali varia tra 0.9-1.2 mg a. gallico equivalente/g, di cui circa il 9% è costituito da flavonoidi. Riguardo la presenza di attività esterasica e lipolitica, tutti i campioni hanno mostrato una maggior specificità nei confronti di acidi grassi a catena corta. Infine, per quanto riguarda la presenza di attività proteolitica, negli estratti è stata rilevata una moderata attività gelatinolitica sia in soluzione che su gel.
Conclusioni
I dati ottenuti dalle analisi condotte sugli estratti di A. rusticana mostrano una buona capacità di radical scavenging ed un contenuto in polifenoli simile a quello delle altre Brassicaceae.
Un aspetto interessante di questo lavoro, considerando la scarsità di dati disponibili in letteratura, è rappresentato dallo studio preliminare circa la presenza di attività esterasica, lipolitica e proteolitica nelle radici di A. rusticana
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
- …
