101 research outputs found
Deletion of the last two exons of FGF10 in a family with LADD syndrome and pulmonary acinar hypoplasia
No full textFrom quantum stochastic differential equations to Gisin-Percival state diffusion
No full textStarting from the quantum stochastic differential equations of Hudson and Parthasarathy Commun. Math. Phys. 93, 301 (1984) and exploiting the Wiener-Itô-Segal isomorphism between the boson Fock reservoir space �(L2(�+)�(�n��n)) and the Hilbert space L2(μ), where μ is the Wiener probability measure of a complex n-dimensional vector-valued standard Brownian motion (B(t),t�0), we derive a non-linear stochastic Schrödinger equation describing a classical diffusion of states of a quantum system, driven by the Brownian motion B. Changing this Brownian motion by an appropriate Girsanov transformation, we arrive at the Gisin-Percival state diffusion equation N. Gisin and J. Percival, J. Phys. A 167, 315 (1992). This approach also yields an explicit solution of the Gisin-Percival equation, in terms of the Hudson-Parthasarathy unitary process and a randomized Weyl displacement process. Irreversible dynamics of system density operators described by the well-known Gorini-Kossakowski-Sudarshan-Lindblad master equation is unraveled by coarse-graining over the Gisin-Percival quantum state trajectories. © 2017 Author(s)
Viscous streaming-enhanced inertial particle transport
No full textFluidic devices operating at the micro- and milli-meter scales employ several fundamental tasks involving pumping, mixing, separation, sorting, storing and transport of different fluids (or) species. An attractive fluid mechanism that can be leveraged to fulfill these wide range of tasks is viscous streaming, a non-linear effect characteristic of the scales above. In this thesis, we first show that numerical simulations based on the Remeshed Vortex Method (RVM) can accurately and efficiently capture viscous streaming dynamics. We test this algorithm on a wide variety of settings while simultaneously exhibiting the resultant streaming flow--structures, demonstrating both streaming's capability of effecting flow control and our solver's robustness in capturing these structures. We then consider the problem of an idealized two-dimensional inertial particle transport and prove that transport can be augmented by sensibly utilizing the streaming mechanism. We then successfully perform a forward--design study to devise shapes capable of enhanced transport using this mechanism, capitalizing on the insights gained from our demonstrations above. We envison such transport applications in the emergent technology of miniature robots, capable of traversing our blood stream to deliver payloads of therapeutical drugs.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2020-12-01The student, Tejaswin Parthasarathy, accepted the attached license on 2018-12-12 at 17:19.The student, Tejaswin Parthasarathy, submitted this Thesis for approval on 2018-12-12 at 17:27.This Thesis was approved for publication on 2018-12-13 at 16:32.DSpace SAF Submission Ingestion Package generated from Vireo submission #13309 on 2019-02-08 at 11:42:06Made available in DSpace on 2019-02-08T18:44:46Z (GMT). No. of bitstreams: 2
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Previous issue date: 2018-12-13Embargo set by: Seth Robbins for item 109991
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Coauthor prediction for junior researchers
No full textResearch collaboration can bring in different perspectives and generate more productive results. However, finding an appropriate collaborator can be difficult due to the lacking of sufficient information. Link prediction is a related technique for collaborator discovery; but its focus has been mostly on the core authors who have relatively more publications. We argue that junior researchers actually need more help in finding collaborators. Thus, in this paper, we focus on coauthor prediction for junior researchers. Most of the previous works on coauthor prediction considered global network feature and local network feature separately, or tried to combine local network feature and content feature. But we found a significant improvement by simply combing local network feature and global network feature. We further developed a regularization based approach to incorporate multiple features simultaneously. Experimental results demonstrated that this approach outperformed the simple linear combination of multiple features. We further showed that content features, which were proved to be useful in link prediction, can be easily integrated into our regularization approach. © 2013 Springer-Verlag
SLC2A9 and Hyperuricemia: A Locus-Wide Association Study To Identify Population-Specific Genetic Variants In New Zealand Māori and Pacific People
No full textHyperuricemia, pathologically defined as the presence of an elevated level of serum urate, is a prerequisite for gouty arthritis. The solute carrier family 2 member 9 (SLC2A9) gene that encodes a urate transporter tops the list of hyperuricemic genes. It is a key genetic determinant of serum urate levels and explains about 3% of urate variance. Gout is highly prevalent in the New Zealand Māori and other Polynesian populations. As an attempt to understand the reason for this increased prevalence, this study focused on the identification and characterisation of Polynesian-specific genetic variants within the SLC2A9 locus conferring susceptibility to hyperuricemia.
The SLC2A9 locus was resequenced in 809 individuals (Polynesian, n = 440 and European, n = 369) comprising hyperuricemic cases and normouricemic controls. All Polynesians were from New Zealand while Europeans were from New Zealand and the United States. Association analysis was carried out to identify variants within the SLC2A9 locus that confer risk for hyperuricemia. Multiple adjusted logistic regression analysis was carried out using R version 3.4.1. A number of data visualization techniques and variant annotation tools were used to interpret and represent data and variant annotations.
A total of 3963 variants was identified within the locus, of which 25 and 53 variants displayed nominal significance (p-value ≤ 0.05) with hyperuricemia in the East and West Polynesians, respectively. These significant signals were further analysed. Five variants were chosen for replication via genotyping (VAR_CHR4_9914056, rs373311989, VAR_CHR4_9452283, VAR_CHR4_10160679 and VAR_CHR4_10457448). The A allele of VAR_CHR4_9914056, located in intron 7 of the SLC2A9 gene, was found to be associated with hyperuricemia in the East Polynesians in the Discovery Cohort (adjusted OR = 28.30, POR = 0.003) and the association was successfully replicated in the larger independent Replication Cohort, although with a relatively smaller effect size (adjusted OR = 2.93, POR = 0.004).
The variants prioritized for replication were also tested for the association with gout in Polynesians. The A allele of the intergenic variant, VAR_CHR4_10160679, showed a significant protective association with gout both during discovery (adjusted OR = 0.04, POR = 0.03) and replication (adjusted OR = 0.32, POR = 0.01) in West Polynesians. The region containing this variant (4:10120364 – 4:10494666) displayed variation in the haplotype structure in Polynesians compared to Europeans, as revealed by haplotype analysis and visualization.
This research was conducted to provide a greater insight into the genetic causes of gout and understand the reason for the higher prevalence of hyperuricemia in Polynesians. The work signifies the usefulness of targeted resequencing, especially in a bespoke fashion, in studying the genetic basis of a trait/disease that is highly prevalent in a particular population and further evinces the association of non-coding variants in the SLC2A9 locus, mapping to the human 4p16.1 chromosomal region, with hyperuricemia and gout in Polynesians. The study also demonstrates the utility of data visualization tools and techniques in exploratory big data analysis. The identification of the Polynesian-specific hyperuricemia-associated variant can be applied in precision medicine and public health genomics to improve health outcomes for the target population
Toward Inclusive, Vital and Livable City Scenarios: The Transformation of Urban Villages in Shenzhen
No full textCurrently Shenzhen is experiencing industrial upgrading and city reprofiling, transforming from a world factory to a world city. It is a crucial moment to rethink the future of urban villages in the city, informal settlements that emerged extensively along with rapid industrialization and urban development in the past three decades, and played essential roles as “arrival cities” for migrants. This chapter investigates the formation process of urban villages as well as planning strategies for future development, from the perspective of urban form and governance. Urban vitality, livability, and inclusiveness are addressed as multidimensional urban values that could generate common interests among stakeholders, which therefore could be considered desirable and possible future scenarios for such neighborhoods in Shenzhen.Accepted Author ManuscriptSpatial Planning and Strateg
Surfactant mixtures at the oil–water interface
No full textNOTICE: this is the author’s version of a work that was accepted for publication in Journal of Colloid and Interface Science. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in JOURNAL OF COLLOID AND INTERFACE SCIENCE, VOL 398, (2013) DOI 10.1016/j.jcis.2013.01.06
Construction and Demolition Waste Impact, Policy and Diversion
No full textabstract: Humans, throughout the world, build houses to live in and raise their families. The construction of houses and other buildings produces a large quantity of waste during this process. This waste is not necessarily biodegradable or derived from environmentally friendly materials. They often damage the environment causing pollution and contributing to greenhouse gas emissions (Tam, V. W., & Tam, C. M, 2012). This type of waste is categorized as Construction and Demolition(C&D) waste. My culminating experience focuses on C&D waste and this summary is divided into three parts. In the first part, the report covers the impact of the C&D waste in sustainability. Considering the three pillars of sustainability the effect of C&D waste on these three pillars are analyzed. The second part is the policy analysis surrounding current C&D waste in cities within the states of Arizona, Oregon and California. This section also covers the current practices and impact that the policies have had in diverting C&D waste from landfill. The report features application of conceptual mapping to explore the issues surrounding C&D waste in the circular economy, and intervention points for waste diversion. The third part of this project focuses on a selected intervention point: Community engagement, and education. The report also discusses the processes and strategies applied to organize an event to create art from salvaged building supplies. Stardust celebrated their 20th year anniversary in April 2017. In collaboration with them, the “Salvage This” event was organized to engage with artists, to exhibit arts created from salvaged building supplies, and promote reuse concept in the community
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