1,355,878 research outputs found
Using seasonal climate forecasting in agriculture: a participatory decision-making approach
No full textFarm Management,
Packham, K, 436776
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/409187Surname: PACKHAM. Given Name(s) or Initials: K. Military Service Number or Last Known Location: 436776. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 56884.224631
Item: [2016.0049.41458] "Packham, K, 436776
Opportunities in primary care for reducing stroke rates: a cross-sectional study of the differences in the control of hypertension between ethnic groups
No full textAim: to compare blood pressure control and management patterns among hypertensive patients of Caucasian and ethnic minority origin.Methods: this study involved a retrospective case-note assessment of the quality of care received over a 3-year period of 199 Caucasian and 50 ethnic minority patients with established essential hypertension attending an inner city UK general medical practice.Results: compared to Caucasian patients, patients from ethnic minority origins were more likely to have a mean diastolic blood pressure above 90 mmHg adjusted for age, gender, diabetes, body mass index, smoking, alcohol, and family history of cardiovascular and cerebrovascular disease (OR = 2.6, p = 0.02). Ethnic minority patients had an average of five more general practice visits annually than Caucasian patients (p < 0.01). However, the mean number of blood pressure readings per year did not differ significantly between the two groups. The most commonly used antihypertensive drug in ethnic minority patients was atenolol compared to bendroflauzide in Caucasian patients.Conclusions: there is scope for improving the control of blood pressure, and hence influencing vascular disease rates, in ethnic minority populations. The use of evidence-based hypertension treatment tailored to ethnic origin could be improved and the higher number of GP visits for these patients could be utilized to optimize blood pressure control. However, public health strategies need to take account of the possible higher primary care workload inherent in achieving good control in such population
BAG-1: a multi-functional pro-survival molecule
No full textBAG-1 is a multi-functional protein that exists as three functionally distinct and differentially localized isoforms which originate from a single mRNA and interact with a wide range of cellular targets. These include heat shock proteins, nuclear hormone receptors, signalling molecules, the anti-apoptotic BCL-2 protein and components of the ubiquitylation/proteasome machinery. Overexpression of BAG-1 isoforms has been demonstrated to regulate apoptosis, proliferation, transcription, metastasis and cell motility in a wide variety of cell systems. Since BAG-1 has a role in many biological pathways there is increasing evidence supporting the view that BAG-1 is an important molecule in disease, for example, potentially modulating both cell survival and response to nuclear hormones in breast cancer, and BAG-1 is a potential molecular target for therapeutic intervention
Comparative Discourse Strategies in Environmental Advocacy: Analysing the Rhetoric of Greta Thunberg and Chris Packham
No full textThis paper examines the rhetoric and argumentation of two prominent environmental activists, Greta Thunberg and Chris Packham. From the perspective of Ecolinguistics, Thunberg has given voice to a generational movement for change, galvanising young people everywhere through high-profile protests and speeches. Packham represents British mainstream environmentalism, notably as the presenter of the acclaimed nature documentary ‘Springwatch’. We argue that their influence partially stems from their alignment with dominant cultural narratives: Thunberg’s emphasis on intergenerational discord and Packham’s connection to the natural world. We analyse both figures via the lens of the ‘emotionalisation of media discourse’, highlighting argumentation strategies that feature expressions of negative emotions of which anger is a type. Thunberg’s famous ‘How dare you?’ outburst at the 2019 UN Climate Action Summit and Packham’s statement to Novara Media, ‘I am more angry now than at any point since my 20s’, exemplify this trend. We explore the pragmatic implications of their argumentative and discursive strategies, suggesting that while both have significantly elevated the profile of ecological activism, their discourse may also have a potentially divisive aspect
Regulation of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Burkitt's lymphoma cell lines
No full textTumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in sensitive cells and may be suitable for novel anti-cancer therapies aimed at inducing apoptosis via the activation of TRAIL receptors on malignant cells. Here we have characterized the TRAIL sensitivity of a panel of Burkitt's lymphoma (BL) cell lines. Overall, 5/12 BL cell lines and 1/2 lymphoblastoid cell lines were sensitive to TRAIL-induced apoptosis, although only one BL cell line approached the sensitivity of Jurkat cells, a widely used model for TRAIL-induced apoptosis. Whereas, 4/5 of the Epstein–Barr virus (EBV)-negative cell lines were TRAIL sensitive, only 1/7 EBV-positive BL cell lines were TRAIL sensitive. However, isogenic BL cell lines with different EBV status were not differently sensitive to TRAIL, indicating that EBV is not a major determinant of TRAIL sensitivity. All cell lines expressed the death receptor (DR)5 TRAIL receptor, whereas expression of DR4 was more variable. Differences in the expression of downstream signalling molecules [Fas-associated death domain protein (FADD), caspase 8] and inhibitors [decoy receptor 1 (DcR1), cellular FLICE-like inhibitory protein (c-FLIP)] did not correlate with TRAIL sensitivity. Therefore, a subset of BL cell lines are sensitive to TRAIL-induced apoptosis, however, the molecular mechanism that determines responsiveness remains to be identified
Purification of primary malignant B-cells and immunoblot analysis of bcl-2 family proteins
No full textThe ability to isolate relatively pure populations of primary normal and malignant lymphocytes has brought studies of lymphoid malignancies to the forefront of cancer research. Apoptosis (programmed cell death) plays a key role in controlling normal B-cell numbers, and resistance to apoptosis contributes to lymphomagenesis and reduces the effectiveness of chemotherapy and radiotherapy. Multiple Bcl-2 family proteins orchestrate key life and death decisions in lymphocytes, and the prototypical family member, Bcl-2, is activated by reciprocal translocation in human lymphoma. Here, we describe an immunomagnetic method to isolate and purify malignant B-cells suitable for in vitro analyses from lymph node biopsies. Methods to analyze the expression of Bcl-2 family proteins by immunoblotting also are described
The Joys and Opportunities of Magazine Publishing
No full textRachel Barrett: Editor in Chief, Country Living Magazine, Hearst Magazines Jeff Joseph: Publisher & Editorial Director, Luckbox Magazine Jeremy Leslie: Founder & Curator, MagCulture, It\u27s a Mag, Mag World! Jo Packham: Creator/Editor in Chief, & 2018 Magazine Launch of the Year, Where Women Create, Where Women Cook, Where Women Create Work, & What Women Create Magazines
Link to Jeff Joseph\u27s presentation
Link to Jeremy Leslie\u27s presentation
Link to Jo Packham\u27s presentatio
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
La pera Packham´s, la terminación del fruto, el russet y el folclore regional
No full textEn noviembre de 2022, en Río Colorado, durante una reunión con productores frutícolas para tratar la temática sobre fungicidas para el control de sarna del manzano, el autor de esta nota fue inquirido acerca del uso de Ziram/Zineb en Packham´s para mejorar la terminación del fruto.
Como no es la primera vez que se plantea este vínculo entre fungicidas y terminación del fruto en pera Packham´s, sugerí -recurriendo al manual del extensionista- que los interesados hicieran la prueba en medio cuadro, a fin de hacer la propia evaluación.
Luego, en lo inmediato recopilamos opiniones entre colegas. Aquí presentamos un resumen: la terminación del fruto en Packham`s puede tener varias causas y la aplicación de fungicidas no incide en todas ellas.
El russet constituye un deterioro cosmético del fruto: hay un quiebre y endurecimiento de la cutícula, perdiendo su rol protector. Lo que observamos son restos de células necróticas. Según la bibliografía (entre ellos Yuri1 ), el período de mayor sensibilidad del fruto coincide con el de división celular: desde plena floración hasta 25-35 días después. Las causas pueden ser internas (la cuestión varietal y la posición del fruto en el árbol), y externas (clima, agroquímicos, daño mecánico, estado sanitario y nutrición).EEA Alto ValleFil: De Rossi, Rafael Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Alto Valle. Agencia de Extensión Rural Rio Colorado; Argentin
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