1,721,050 research outputs found
Interference of medroxyprogesterone acetate (MPA) and verapamil (VERA) on membrane fluidity and polarity variations by some anthracyclines on cardiomyocytes and thymocytes.
No full textRanking Love Numbers for the Neutron Star Equation of State: The Need for Third-Generation Detectors
Full text linkGravitational-wave measurements of the tidal deformability in neutron-star binary coalescences can be used to infer the still unknown equation of state (EOS) of dense matter above the nuclear saturation density. By employing a Bayesian-ranking test, we quantify the ability of current and future gravitational-wave observations to discriminate among families of nuclear-physics based EOS which differ in particle content and ab initio microscopic calculations. While the constraining power of GW170817 is limited, we show that even twenty coalescences detected by LIGO-Virgo at design sensitivity are not enough to discriminate between EOS with similar softness but distinct microphysics. However, just a single detection with a third-generation detector such as the Einstein Telescope or Cosmic Explorer will rule out several families of EOS with very strong statistical significance and can discriminate among models which feature similar softness, hence, constraining the properties of nuclear matter to unprecedented levels
Bayesian parameter estimation on boson-star binary signals with a coherent inspiral template and spin-dependent quadrupolar corrections
No full textCompact boson-star binaries are hypothetical sources for ground-based and space gravitational-wave detectors. Their signal would be a messenger for novel fundamental fields and could shed light on the dark matter. In this work, we further develop our analysis [Phys. Rev. D 102, 083002 (2020)], aimed at constraining the properties of these objects with future observations. We use a coherent waveform template for the inspiral stage of boson-star binaries with large quartic self-interactions, including tidal deformability and the nonlinear dependence of the quadrupole moments on the spin in terms of the fundamental couplings of the scalar field theory. Performing a Bayesian analysis, we investigate the ability of a thirdgeneration gravitational-wave detector such as the Einstein Telescope to distinguish these exotic sources from black holes and infer constraints on the fundamental couplings of the model
Latest developments in gene transfer technology: achievements, perspectives and controversies over therapeutic applications
No full textOver the last decade, more than 300 phase I and phase II gene-based clinical trials have been conducted worldwide for the treatment of cancer and monogenic disorders. Lately, these trials have been extented to the treatment of AIDS and, to a lesser extent, cardiovascular diseases. There are 27 currently active gene therapy protocols for the treatment of HIV-1 infection in the USA. Preclinical studies are currently in progress to evaluate the possibility of increasing the number of gene therapy clinical trials for cardiopathies, and of beginning new gene therapy programs for neurologic illnesses, autoimmuno diseases, allergies, regeneration of tissues, and to implement procedures of allogeneic tissues or cell transplantation. In addition, gene transfer technology has allowed for the development of innovative vaccine design, known as genetic immunization. This technique has already been applied in the AIDS vaccine programs in the USA. These programs aim to confer protective immunity against HIV-1 transmission to individuals who are at risk of infection. Research programs have also been considered to develop therapeutic vaccines for patients with AIDS and generate either preventive or therapeutic vaccines against malaria, tuberculosis, hepatitis A, B and C viruses, influenza virus, La Crosse virus, and Ebola virus. The potential therapeutic applications of gene transfer technology are enormous. However, the effectiveness of gene therapy programs is still questioned. Furthermore, there is growing concern over the matter of safety of gene delivery and controversy has arisen over the proposal to begin in utero gene therapy clinical trials for the treatment of inherited genetic disorders. From this standpoint, despite the latest significant achievements reported in vector design, it is not possible to predict to what extent gene therapeutic interventions will be effective in patients, and in what time frame
Follicular thyroid carcinoma and mediastinal goiter in a case of situs inversus viscerum
No full textGene transfer technology in therapy: Current applications and future goals
No full textGene therapy has attracted much interest since the first submissions of phase I clinical trials in the early 1990s, for the treatment of inherited genetic diseases. Preliminary results were very encouraging and prompted many investigators to submit protocols for phase I and phase II clinical trials for the treatment of inherited genetic diseases and cancer. The possible application of gene transfer technology to treat AIDS, cardiopathies, and neurologic diseases is under evaluation. Some viral vectors have already been used to deliver HIV-1 subunits to immunize volunteers who are participating in the AIDS vaccine programs in the USA. However, gene delivery systems still need to be optimized in order to achieve effective therapeutic interventions. The purpose of this review is to summarize the latest achievements in improving gene delivery systems, their current application in preclinical studies and in therapy, and the most pressing issues that must be addressed in the area of vector design
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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