1,721,154 research outputs found
Lateral dual energy X-ray absorptiometry versus quantitative computed tomography for the diagnosis of osteoporosis.
No full textDriving Under the Influence of Drugs: Looking for Reasonable Blood Cutoffs and Realistic Analytical Values
No full textMass spectrometry vs. immunoassay in clinical and forensic toxicology: qui modus in rebus est?
No full textLe prospettive del Laboratorio di Tossicologia forense
No full textIl Convegno intende portare all'attenzione di Medici, Biologi e Tecnici di Laboratorio impegnati nelle analisi cliniche di routine e di emergenza, nonché ai clinici coinvolti nelle tematiche medico-legali, gli aggiornamenti sulla determinazione dei dosaggi delle nuove droghe di abuso e sulle problematiche dell'emergenza pediatrica in ambito tossicologico. Verrà inoltre trattato l'inquadramento del ruolo del Laboratorio nella Tossicologia Forense, considerando lo stato dell'arte e le sue prospettive.The conference intends to bring to the attention of Doctors, biologists and Lab Technicians engaged in routine clinical analysis and emergency, and clinicians involved in the medico-legal issues, updates on the determination of the dosages of new drugs of abuse and the problems of pediatric emergency in toxicology. It will be also discussed the framework of the role of the Forensic Toxicology Laboratory, considering the state of the art and its prospects
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
European drug users at risk from illicit fentanyls mix
Full text linkThe increase of overdose deaths involving licit and illicit fentanyl analogs (FAs), recently observed
in North America, has shifted toward Europe posing a serious public health menace (Mounteney
et al., 2015).
The widespread appearance of these synthetic opioids, between 50 and 100 times more potent
than morphine and in many cases not approved for medical use, has been reported by the European
Monitoring Centre for Drugs and Drug Addiction (European Drug Report, 2017)..
Indeed, in the last few years a number of FAs, (e.g., despropionyl-2-fluorofentanyl,
furanylfentanyl, valerylfentanyl, acryloylfentanyl, carfentanyl, butyrfentanyls) has appeared for the
first time on the European illicit market having caused more than 100 fatalities, when used alone or
in association to other drugs (UNODC, 2017).
Due to the low cost of the required materials and equipment for producing these compounds in
clandestine laboratories inside and outside Europe, they are sold by drug dealers in place of heroin
or mixed with it as cutting agents. In this context, the possibility of fatal overdoses is extremely
high because of the narrow range between a safe and a lethal dose and the manufacturing of
quantitatively inaccurate and contaminated products
Sex enhancers: challenges, threats and the need for targeted measures
Full text linkSex enhancers: challenges, threats and the need for targeted measure
Lateral dual X-ray absorptiometry (DXA) and quantitative computed tomography discriminates better between normal and osteoporosis than antero-posterior DXA
No full textInterleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines
No full textIn unstimulated conditions osteoclast renewal occurs as a result of the stromal cell production of the key osteoclastogenic factors, receptor activator of NFkB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF), Inflammation is known to cause increased osteoclastogenesis; however, the mechanisms responsible for this phenomenon are poorly understood. We now show that interleukin-1 (II-1) and tumor necrosis factor alpha (TNF alpha), cytokines typically produced in inflammatory conditions, increase the stromal cell production of IL-7, This factor, in turn, up-regulates production of osteoclastogenic cytokines by T cells leading to stimulation of osteoclast (OC) formation. Although T cells were found to produce soluble forms of both RANKL and M-CSF, saturating concentrations of osteoprotegerin failed to inhibit approximately 40% of the OC formation, suggesting that IL-7 acts via both RANKL-dependent and RANKL-independent pathways, Despite the identification of T-cell-secreted M-CSF, this cytokine was not essential for either RANKL-dependent or -independent OC formation, suggesting that T cells secrete other cytokines capable of substituting for M-CSF action, On the basis of our data, we propose a novel mechanism for inflammatory bone loss in which induction of IL-7 from stromal cells by IL-l and TNF alpha leads to the production of soluble osteoclastogenic cytokines by T cells. Thus, the mechanism by which IL-7 causes bone resorption involves the activation of T cells and the T-cell-dependent augmentation of osteoclastogenesis, (C) 2000 by The American Society of Hematology
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