1,721,005 research outputs found
Dalla percezione del presente agli scenari futuri: esplorando l’ambiente attraverso i paesaggi mentali individuali
No full textResearch on Education for Sustainable Development: a national network at its first steps
No full text
Environment, our common future: Exploring students’ perceptions in an environmental education framework
No full text
Promoting education for sustainability: a challenge for the University systemThe experience of the Italian Centre for Research and Environmental Education (C.I.R.E.A.) of the University of Parma (Italy)
No full textIndagini sul ruolo delle esperienze e delle attività scolastiche nell'educazione ambientale
No full text
Intensification of Double Kinetic Resolution of Chiral Amines and Alcohols via Chemoselective Formation of a Carbonate–Enzyme Intermediate
No full textChiral amines and alcohols are synthons of numerous pharmaceutically-relevant compounds. The previously developed enzymatic kinetic resolution approaches utilize a chiral racemic molecule and achiral acyl donor (or acyl acceptor). Thus, only one enantiodivergent step of the catalytic cycle is engaged, which does not fully exploit the enzyme’s abilities. The first carbonate-mediated example of simultaneous double chemoselective kinetic resolution of chiral amines and alcohols is described. Herein, we established a biocatalytic approach towards four optically-pure compounds (>99% ee, Enantioselectivity: E > 200) via double enzymatic kinetic resolution, engaging chiral organic carbonates as acyl donors. High enantioselectivity was ensured by extraordinary chemoselectivity in lipase-catalyzed formation of unsymmetrical organic carbonates and engaged in a process applicable for the synthesis of enantiopure organic precursors of valuable compounds. This study focused not only on preparative synthesis, but additionally the catalytic mechanism was discussed and the clear impact of this rarely observed carbonate-derived acyl enzyme was shown. The presented protocol is characterized by atom efficiency, acyl donor sustainability, easy acyl group removal, mild reaction conditions, and biocatalyst recyclability, which significantly decreases the cost of the reported process
- …
