121,824 research outputs found
Cannibalism control in the rearing marine species: ordinary techniques and alternative strategies
No full textExploring teacher’s perspective on physical education with transgender, intersex and non-binary students. A Systematic Review of Qualitative Studies
No full textHaase RK, Brunßen L, Kastrup V. Exploring teacher’s perspective on physical education with transgender, intersex and non-binary students. A Systematic Review of Qualitative Studies. York, UK: PROSPERO; 2024
Reprogramming cell death: BCL2 family inhibition in hematological malignancies
No full textThe BCL2 family members play a central role in regulating programmed cell death (apoptosis) and arbitrating the cellular fate through an accurate balance between pro-apoptotic (BAX, BAK, and BH3-only proteins) and pro-survival (BCL2 and its closest homologues, BCLXL, BCLW and MCL-1) factors. Deregulation of BCL2 family proteins contributes to programmed cell death evasion, that is a hallmark of human cancers and it is often related to (chemo)therapy resistance. High BCL2 levels have been detected in most human lymphoid malignancies, not limited to follicular lymphoma (where the role of BCL2 overexpression is driven by the 414;181 translocation) but also B-cell chronic lymphocytic leukemia (CLL) and multiple myeloma. For all these reasons, the opportunity to induce apoptosis by targeting BCL2 proteins is considered a potentially promising therapeutic approach in hematological malignancies. BCL2 family inhibition strategies currently explored in phase 1,2 and 3 clinical trials are essentially two: (1) the use of antisense-based strategies to knockdown BCL2 or BCLXL expression (e.g. oblimersen) or (2) the use of synthetic BH3 mimetics i.e. small molecules binding to anti-apoptotic inhibitors thereby allowing the pro-apoptotic activity of BH3-only molecules (e.g. obatoclax, AT-101, ABT-737 and its derivatives ABT-263 and ABT-199). Several of these drugs demonstrated relevant clinical activity as single-agent or in combination therapy, with the most significant drawbacks in clinical use being represented by challenging pharmacokinetic profile (e.g. iv administration, high-levels of plasma proteins binding) and on-target side effects (e.g. gastrointestinal toxicity and thrombocytopenia). Further clinical development of the current compounds (e.g. ABT-199), showing high efficacy but devoid of the most threatening drug-related toxicities, is eagerly awaited. Hopefully, in the next future, BCL2 inhibitors (alone or in combination with immuno- and/or chemo-therapeutic agents). will represent target-specific drugs expanding our therapeutic armamentarium in the fight against hematologic malignancies. (C) 2013 Elsevier B.V. All rights reserved
Chromosomal diversification and karyotype evolution of diploids in the cytologically diverse genus Prospero
No full textThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited
Indagine preliminare sulla mortalità della spigola (Dicentrarchus labrax) nelle prime fasi di allevamento. Incidenza dell’aggressività intraspecifica. “
No full textResource Sharing in the Internet of Things and Selfish Behaviors of the Agents
No full textResource sharing is an issue for different fields of applications, giving rise to the so-called 'Tragedy of the commons.' This is particularly important in reference to the upcoming Internet of Things, where selfish behaviors from individual users jeopardize system cooperation, on which most network functions rely. We analyze two ways of splitting resources in the context of channel allocation for wireless systems. We describe the outcomes of the different strategies and we identify criteria for the emergence of selfish behaviors in such games
A mosaic genetic screen for novel mutations affecting Drosophila neuroblast divisions
No full textBackground: The asymmetric segregation of determinants during cell division is a fundamental mechanism for generating cell fate diversity during development. In Drosophila, neural precursors (neuroblasts) divide in a stem cell-like manner generating a larger apical neuroblast and a smaller basal ganglion mother cell. The cell fate determinant Prospero and its adapter protein Miranda are asymmetrically localized to the basal cortex of the dividing neuroblast and segregated into the GMC upon cytokinesis. Previous screens to identify components of the asymmetric division machinery have concentrated on embryonic phenotypes. However, such screens are reaching saturation and are limited in that the maternal contribution of many genes can mask the effects of zygotic loss of function, and other approaches will be necessary to identify further genes involved in neuroblast asymmetric division.
Results: We have performed a genetic screen in the third instar larval brain using the basal localization of Miranda as a marker for neuroblast asymmetry. In addition to the examination of pupal lethal mutations, we have employed the MARCM (Mosaic Analysis with a Repressible Cell Marker) system to generate postembryonic clones of mutations with an early lethal phase. We have screened a total of 2,300 mutagenized chromosomes and isolated alleles affecting cell fate, the localization of basal determinants or the orientation of the mitotic spindle. We have also identified a number of complementation groups exhibiting defects in cell cycle progression and cytokinesis, including both novel genes and new alleles of known components of these processes.
Conclusion: We have identified four mutations which affect the process of neuroblast asymmetric division. One of these, mapping to the imaginal discs arrested locus, suggests a novel role for the anaphase promoting complex/cyclosome (APC/C) in the targeting of determinants to the basal cortex. The identification and analysis of the remaining mutations will further advance our understanding of the process of asymmetric cell division. We have also isolated a number of mutations affecting cell division which will complement the functional genomics approaches to this process being employed by other laboratories. Taken together, these results demonstrate the value of mosaic screens in the identification of genes involved in neuroblast division
Alpino, Prospero
No full textBotanico: Alpino, Prospero (1553-1617).
Medico, esploratore ed illustratore dell\u27Egitto, indi professore dell\u27Università di Padova.
Ricoprì la carica di Prefetto dell\u27Orto Botanico di Padova dal 1603 al 1616.
Note manoscritte sul verso: foto quadro (prima del restauro) ad olio di Prospero Alpino, del pittore Leandro Da Ponte, conservato a Stuttgard; dono del prof. Gamba, 7/4/1983.
1 fotografia : gelatina a sviluppo ; 153 x 111 mm.
Vai alla scheda bibliografica: https://galileodiscovery.unipd.it/discovery/fulldisplay?context=L&vid=39UPD_INST:VU1&search_scope=MyInst_and_CI&tab=Everything&docid=alma99001603931020604
Weaning of wild seabream juveniles (Diplodus sargus L.) and observations on the mobility behaviour
No full text- …
