1,721,009 research outputs found
Structural overview of technetium compounds (1993-1999)
No full textThis paper investigates the structural aspects of technetium-containing complexes. The focus is on the description of the various coordination environments around the technetium center. The complexes are divided according to the coordination sphere and the most significant structural parameters are reviewed and discussed. The review covers the crystallographic determinations published in the years between 1993 and 1999. (C) 2001 Elsevier Science B.V. All rights reserved
Mononuclear six-coordinated Ga(III) complexes: A comprehensive survey
No full textGiven the commercial availability of (68)Ge-(68)Ga generators, in principle analogous to the worldwide utilized (99)Mo-(99m)Tc generator, it is surprising that few (68)Ga agents have been developed beyond basic research toward clinical application. The use of the unconventional (68)Ga positron emitter would allow for a cost-effective production of (68)Ga radiotracers far from a cyclotron facility. Moreover, the use of (67)Ga radiopharmaceuticals for imaging studies, and the application of non-radioactive gallium compounds in the treatment of important disorders, including a number of cancer and infectious diseases, make studies on trivalent Ga coordination chemistry attractive for the design of novel gallium-based drugs. The aim of this review is to survey the reported crystal data of six-coordinated Ga(III) complexes in order to gain information to be used in the design of novel Ga complexes of medicinal interes
Zinc coordination complexes as anticancer agents
No full textZinc, present in all forms of life, is an essential element for humans. It is one of the most abundant metals in our body. Because of its importance, any malfunctions of its homeostasis can lead to different disease states, also related to the development of cancer. On the other hand, several Zn complexes have been recognized for their biological activities principally for preventive effects on infectious diseases and for low toxicity. Among different applications in medicinal chemistry, zinc-based complexes have shown to be appealing as anticancer drugs with low toxicity or as photosensitizers in Photo Dynamic Therapy. Here we present an overview of Zn coordination complexes proposed in the last six years as anticancer agents, trying to find a correlation between their chemical features and biological activity, and to evidence the potential perspectives of their use. Despite the great amount of work done in this field, this is the first exhaustive review on antitumor zinc complexes, that might be of wide interest for the researchers in the design and synthesis of new antitumor zinc-based drugs alternative to platinum derivatives
La disinformazione nel conflitto in Ucraina: tra ius in bello e diritto alla libertà di espressione
No full textNel testo è analizzato il tema della disinformazione in tempo di guerra per accertare se esistano norme di ius in bello applicabili. Inoltre, è approfondita la possibilità di applicare le norme a tutela dei diritti umani, con particolare riguardo alle misure adottate nel caso della Russia
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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