186,445 research outputs found

    Description and use of a new piezosurgery insert for tooth preparation

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    Purpose In aesthetic rehabilitation the final touches and repositioning of the finishing line is a critical moment for the final success. In this situation the use of non-rotating instruments can be a valid alternative instead of rotating traditional ones. Moreover sonic and ultrasonic instruments allow greater control by the operator, without any lesion of gingival tissue

    Chronic imipramine, L-sulpiride and mianserin decrease Corticotropin releasing Factor levels in the rat brain

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    Among clinically effective antidepressant drugs, the action mechanism of mianserin has recently been related to variations in corticotropin releasing factor (CRF) levels in the rat locus coeruleus. We describe a specific effect on CRF levels after chronic treatment with different antidepressants: mianserin (10 mg/kg), imipramine (20 mg/kg), both for 21 days, or L-sulpiride (1 mg/kg) for 15 days. While all antidepressants used greatly decreased CRF concentrations in the hypothalamus, only mianserin decreased CRF concentrations by 40% in extrahypothalamic sites. Acute treatments failed to modify CRF levels. Chronic treatment with mianserin did not affect CRF density either in the hypothalamus or the extrahypothalamic areas. This new finding may add another facet to the therapeutic action of certain antidepressants and in particular to the atypical profile of mianserin

    Cannabinoid receptor CB1 mRNA is highly expressed in the rat ciliary body: Implications for the antiglaucoma properties of marihuana

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    We used RT-PCR to measure relative differences in cannabinoid receptor (CB) mRNAs in the rat eye, comparing CB1 or CB2 transcripts to that of the normalizing reference gene β2 microglobulin (β2m). Significantly higher levels of CB1 mRNA levels were found in the ciliary body (0.84 ± 0.05% of β2m) than in the iris, (0.34 ± 0.04% of β2m), retina (0.07 ± 0.005% of β2m) and choroid (0.06 ± 0.005% of β2m). CB2 mRNA was undetectable. This expression pattern supports a specific role for the CB1 receptor in controlling intraocular pressure, helping to explain the antiglaucoma property of cannabinoids
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