1,721,007 research outputs found
Effect of bombesin on basal and stimulated secretion of some pituitary hormones in humans.
No full textThe effect of bombesin (5 ng/kg/min X 2.5 h) on basal pituitary secretion as well as on the response to thyrotropin releasing hormone (TRH; 200 micrograms) plus luteinizing hormone releasing hormone (LHRH; 100 micrograms) was studied in healthy male volunteers. The peptide did not change the basal level of growth hormone (GH), prolactin, thyroid-stimulating hormone (TSH), luteinizing hormone (LH) and follicle-stimulating hormone (FSH). On the contrary, the pituitary response to releasing hormones was modified by bombesin administration. When compared with control (saline) values, prolactin and TSH levels after TRH were lower during bombesin infusion, whereas LH and FSH levels after LHRH were higher. Thus bombesin affects in man, as in experimental animals, the secretion of some pituitary hormones
Bombesin inhibits growth hormone response to insulin-induced hypoglycemia in humans.
No full textIntravenous administration of bombesin (5 ng/kg/min X 2.5 h) significantly reduced growth hormone (GH) response to insulin-induced (0.15 U/kg, i.v.) hypoglycemia in 8 male volunteers without affecting its basal plasma levels. These data, together with the presence of bombesin-like immunoreactivity in the human brain, suggest that--as in experimental animals--this neurogastrointestinal peptide may be of physiological significance in the control of GH secretion also in man
Comparison of insulin lispro protamine suspension versus insulin glargine once daily in basal-bolus therapies with insulin lispro in type 2 diabetes patients: a prospective randomized open-label trial
No full textBiliary pancreatic diversion and laparoscopic adjustable gastric banding inmorbid obesity: their long-term effects on metabolic syndrome and oncardiovascular parameters.
No full textBACKGROUND: Bariatric surgery is able to improve glucose and lipid metabolism,
and cardiovascular function in morbid obesity. Aim of this study was to compare
the long-term effects of malabsorptive (biliary pancreatic diversion, BPD), and
restrictive (laparoscopic gastric banding, LAGB) procedures on metabolic and
cardiovascular parameters, as well as on metabolic syndrome in morbidly obese
patients.
METHODS: 170 patients studied between 1989 and 2001 were called back after a mean
period of 65 months. 138 patients undergoing BPD (n=23) or LAGB (n=78), and
control patients (refusing surgery and treated with diet, n=37) were analysed for
body mass index (BMI), blood glucose, cholesterol, and triglycerides, blood
pressure, heart rate, and ECG indexes (QTc, Cornell voltage-duration product, and
rate-pressure-product).
RESULTS: After a mean 65 months period, surgery was more effective than diet on
all items under evaluation; diabetes, hypertension, and metabolic syndrome
disappeared more in surgery than in control patients, and new cases appeared only
in controls. BPD was more effective than LAGB on BMI, on almost all
cardiovascular parameters, and on cholesterol, not on triglyceride and blood
glucose. Disappearance of diabetes, hypertension, and metabolic syndrome was
similar with BPD and with LAGB, and no new cases were observed.
CONCLUSION: These data indicate that BPD, likely due to a greater BMI decrease,
is more effective than LAGB in improving cardiovascular parameters, and similar
to LAGB on metabolic parameters, in obese patients. The greater effect on
cholesterol levels is probably due to the different mechanism of action
Erythrocytosis in a patient with chronic obstructive pulmonary disease
No full textChronic obstructive pulmonary disease (COPD) can be accompanied by compensatory secondary erythrocytosis. However, the exact prevalence of secondary erythrocytosis in COPD is unknown. Although diagnostic criteria for polycythemia vera versus secondary erythrocytosis are mutually exclusive, we describe here the coexistence of polycythemia vera and COPD in the same patient. (C) 1998, Ferrata Storti Foundation
Weight Loss Through Gastric Banding: Effects on TSH and Thyroid Hormones in Obese Subjects With Normal Thyroid Function
No full textRetinal laser photocoagulation in diabetic patients causes prolactin, growth hormone and cortisol release
No full textBiliary pancreatic diversion and laparoscopic adjustable gastric banding in morbid obesity: their long-term effects on metabolic syndrome and cardiovascular parameters.
No full textAssociation between chlorpropamide alcohol flushing and fast acetylator phenotype in type 1 and type 2 diabetes
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