1,720,964 research outputs found
Non heritable risk factors for Multiple Sclerosis: Epstein Barr virus and elements influencing intestinal permeability.
Full text linkVarianti genotipiche del virus di Epstein Barr e loro usi come possibili predittori di rischio, biomarcatori e target terapeutici nella sclerosi multipla
No full textLa presente invenzione si riferisce ad un acido nucleico codificante per una variante dell’antigene nucleare 2 di Epstein Barr (EBNA2) per uso come biomarcatore per predire il rischio per lo sviluppo e/o la diagnosi e/o la prognosi della sclerosi multipla, e ad un metodo in vitro per predire il rischio per lo sviluppo e/o la diagnosi e/o la prognosi della sclerosi multipla in un soggetto, comprendente il rilevamento della presenza di detto acido nucleico
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Transciptome of B lymphocytes in multiple sclerosis
No full textObjective: Over the past two decades B cells have increasingly moved into the spotlight in multiple sclerosis (MS) research. So far it has not been performed a detailed study of the B cells transcriptome in MS. This may be a prerequisite for identifying the elements that B cells use to carry out their pathogenic role. The primary aim of this project was to analyze the whole B cell-transcriptome (coding and non-coding RNA) in MS context. We studied the differences between MS patients and controls in B cell transcriptome: 1) mRNA including alternative splicing; 2) human microRNAs (miR). Methods: We studied peripheral CD19+ B cell subsets obtained from 10 MS patients, 10 healthy donors (HD), and 2 monozygotic twins discordant for MS. All affected individuals were treatment-naïve and all the investigations were performed at least three months after the last steroid therapy. Total RNA was extracted using miRNeasy Kit (Qiagen). Microarray data was performed using two Affymetrix’s platforms: GeneChip-Human Exon and GeneChip-miRNA. The statistical analysis was performed by means of two different software packages, whose output results have been compared: Partek Genomic Suite (version 6.6) and our own analysis pipe-line based on EasyExon tools. In order to discover and understand the connections among the genes obtained from the analysis, and their position in other biological processes, a pathway analysis was performed using Ingenuity Pathway Analysis (IPA). The miR Analysis was performed by IPA microRNA Target Filter. Results: Firstly, we found that EasyExon is much less permissive than Partek. So we focused on EasyExon results, in particular we selected 26 genes differentially expressed in MS compared HD (p=1.5). The list was then submitted to IPA and performed a pathway analysis that led us to choose seven, among the original 26 genes that were among those differentially expressed MS patients and HD. Furthermore, performing the miR analysis with IPA, it has emerged that 6 genes from our list are targeted by 9 miR differentially expressed in MS/HD groups. Conclusions: Peripheral B cell compartment seems to be promising for the identification of mRNA and miR signature. We have identified an MS-related pattern, in terms of miR and/or genes
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